Abstract：
:The present study investigated the role of micro, delta, and kappa receptors within the RVM in mediating expression of conditional hypoalgesia (CHA). Five groups of rats with RVM cannulae were given daily sessions of paired or unpaired presentations of an auditory CS (white noise) and foot shock across three consecutive days. On the test day, rats in the Paired condition were injected with the micro antagonist CTAP, the delta antagonist naltrindole, the kappa antagonist nor-BNI, or saline. Rats in the Unpaired condition were injected with saline. TFLs were measured before and after injections, as well as during and after presentations of the CS. The results showed that none of the drugs affected baseline TFLs. During CS presentation, rats in the Paired condition injected with saline showed longer TFLs than those in the Unpaired condition given saline, confirming the presence of CHA. Expression of this response was blocked by CTAP, but was unaffected by naltrindole or nor-BNI. These results suggest that mu, but not delta or kappa, opioid receptors in the RVM mediate expression of CHA.
journal_name
Painjournal_title
Painauthors
Foo H,Helmstetter FJdoi
10.1016/S0304-3959(99)00125-6keywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
427-431issue
3eissn
0304-3959issn
1872-6623pii
00006396-199912010-00005journal_volume
83pub_type
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