Abstract：
:After a pilot study had indicated that the topical application of guanethidine might be of value in the treatment of tooth dentine hypersensitivity, a double-blind study was undertaken to investigate whether guanethidine was more effective than a distilled water control in alleviating dentinal pain. In 39 adult subjects, who had complained of dentine hypersensitivity, a 1 sec blast of air from a dental 3-in-1 syringe was directed onto sensitive root dentine at an angle of 90 degrees from a distance of 1 cm. The severity of the resulting pain was indicated by the subject on a 10 cm visual analogue scale (VAS). One droplet of either 1% guanethidine monosulphate (Ismelin, Ciba-Geigy) or distilled water, allocated at random, was applied to the dentine for 1 min. The tooth was re-tested with the standardised air blast and a second VAS was marked by the subject. In total, 19 patients received guanethidine and 20 received water. VAS scores before treatment in the 2 groups treated with either guanethidine or water (means: 6.5 +/- 2.2 and 6.0 +/- 2.5, respectively) were not significantly different (Mann-Whitney, P = 0.48) whereas the VAS scores in the 2 groups after treatment with guanethidine or water (means: 2.7 +/- 2.4 and 4.8 +/- 2.9, respectively) were significantly different (Mann-Whitney, P < 0.02). It was concluded that guanethidine reduced dentinal hypersensitivity more effectively than distilled water.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Painjournal_title
Painauthors
Dunne SM,Hannington-Kiff JGdoi
10.1016/0304-3959(93)90205-4subject
Has Abstractpub_date
1993-08-01 00:00:00pages
165-168issue
2eissn
0304-3959issn
1872-6623pii
00006396-199308000-00007journal_volume
54pub_type
临床试验,杂志文章,随机对照试验相关文献
PAIN文献大全abstract：:We describe audible and ultrasonic vocalization elicited in rats by a short electrical pulse applied to the tail. Three types of vocal emissions were recorded: (1) 'peep', characterized by a repartition of energy over a wide range (0-50 kHz) of frequencies without any clear structure; (2) 'chatters', characterized by ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(95)00049-X
更新日期：1995-11-01 00:00:00
abstract：:A growing body of literature suggests that the experience of clinical pain differs across ethnocultural groups. Additionally, some evidence indicates greater sensitivity to experimentally induced pain among African Americans; however, most studies have included only one pain modality. This study examined ethnic differ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.08.013
更新日期：2005-01-01 00:00:00
abstract：:Noradrenaline increases thermal hyperalgesia in skin previously sensitized by capsaicin. The aim of the present study was to determine whether a vasoconstrictor ischaemic effect of noradrenaline increases thermal hyperalgesia. Heat pain thresholds were measured in the capsaicin-treated and untreated skin on the forear...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(96)03115-6
更新日期：1996-09-01 00:00:00
abstract：:Although EMLA is known to be an effective topical anesthetic, its rate of success is unknown. Indeed, researchers have suggested that EMLA may fail with young and apprehensive children. Therefore, the objectives of this study were to assess EMLA's rate of success as well as factors which predict success. A double-blin...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(95)00100-X
更新日期：1996-01-01 00:00:00
abstract：:A study of the extent of sympathetic blockade after stellate ganglion block was assessed using liquid crystal thermography. Two volumes (10 and 20 ml) of bupivacaine 0.5% plain were used. Irrespective of the volume used cranial sympathetic block always occurred and thoracic sympathetic block never occurred. While uppe...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(89)90023-7
更新日期：1989-02-01 00:00:00
abstract：:Since a number of patients with Parkinson's Disease (PD) complain of painful sensations, we studied whether the central processing of nociceptive inputs is abnormal in PD. To test this hypothesis, we recorded scalp CO(2) laser evoked potentials (LEPs) to hand skin stimulation in 18 pain-free PD patients with unilatera...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.06.022
更新日期：2008-05-01 00:00:00
abstract：:Vascular head pain is thought to result from activation of trigeminal sensory nerve fibers innervating cranial blood vessels. Support for this hypothesis was sought by searching in the trigeminal brain-stem subnucleus caudalis (SNC) for neuronal responses evoked by electrical stimulation of the middle meningeal artery...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(86)90244-7
更新日期：1986-06-01 00:00:00
abstract：:To determine the incidence of pain related sexual dysfunction 1 year after inguinal herniorrhaphy and to assess the impact pain has on sexual function. In contrast to the well-described about 10% risk of chronic wound related pain after inguinal herniorrhaphy, chronic genital pain, dysejaculation, and sexual dysfuncti...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.01.035
更新日期：2006-06-01 00:00:00
abstract：:This study examined the adaptational classification stability of the multidimensional pain inventory (MPI) in two samples of female fibromyalgia syndrome patients. Retest resulted in one-third of patients being assigned to a different classification. Twenty patients had four repeated MPI assessments over a 10-month pe...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.01.014
更新日期：2004-05-01 00:00:00
abstract：:Experimental C-fiber pain caused by radiant heat was applied to the skin area supplied by the left sural nerve of 20 subjects. Percutaneous electrical stimulation (PNS) was performed on the left sural nerve, the left superficial peroneal nerve and the right superficial radial nerve. Stimulation frequencies were: 3, 50...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(79)90004-6
更新日期：1979-10-01 00:00:00
abstract：:Venlafaxine hydrochloride (Effexor) is a structurally novel antidepressant that inhibits reuptake of 5-hydroxytryptamine and noradrenaline, but unlike the older antidepressants, has few side-effects. The objective of this study was to determine whether venlafaxine relieves thermal hyperalgesia in rats with neuropathic...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(96)03223-X
更新日期：1996-11-01 00:00:00
abstract：:Tactile, proprioceptive, and nociceptive information, including also chemosensory functions are expressed in the trigeminal nerve sensory response. To study differences in the processing of different stimulus qualities, we performed a study based on functional magnetic resonance imaging. The first trigeminal branch (o...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2008.05.007
更新日期：2008-10-15 00:00:00
abstract：:Coping with the demands of pain diminishes self-regulatory capacity and causes self-regulatory fatigue, which then leads to deteriorated executive task performance. It has been suggested that optimism can counteract the depletion of self-regulatory capacity. This study employed a 2 (optimism/no optimism)×2 (pain/no pa...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2013.10.014
更新日期：2014-02-01 00:00:00
abstract：:We propose a blade as a noninjurious nociceptive stimulus modeling sharp mechanical pain and yielding acute pain and hyperalgesia responses with closer proximity to incision-induced pain/hyperalgesia than punctate or blunt pressure mechanical pain models. Twenty-six healthy men and women were investigated to compare a...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000352
更新日期：2016-01-01 00:00:00
abstract：:A cohort of 243 female sewing machine operators were studied by questionnaire and clinical examinations with the purpose to study the efficiency of a screening questionnaire-based method to identify prevalent and incident cases of neck-shoulder disorders. The cross-sectional correlation between self-reported neck-shou...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(00)00261-X
更新日期：2000-06-01 00:00:00
abstract：:Our objectives were to determine whether procedural pain and glucose exposure are associated with altered structural and functional brain development differently in preterm males and females, and neurodevelopment at 18-month corrected age. Fifty-one very preterm neonates (22 males; median [interquartile range] gestati...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001123
更新日期：2018-03-01 00:00:00
abstract：:Mechanisms of hypnotic analgesia were investigated by examining changes in the R-III, a nociceptive spinal reflex, during hypnotic reduction of pain sensation and unpleasantness. The R-III was measured in 15 healthy volunteers who gave VAS-sensory and VAS-affective ratings of an electrical stimulus during conditions o...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(94)00134-Z
更新日期：1995-01-01 00:00:00
abstract：:A wide range of environmental stimuli have been shown to induce antinociception. Investigation of the brain regions contributing to environmentally induced antinociception (EIA) has focused primarily on the effect of disrupting neural transmission at various CNS sites. In contrast, the present study analyzed changes i...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(93)90108-2
更新日期：1993-01-01 00:00:00
abstract：:The effects of intrathecal administration of substance P and N-methyl-D-aspartate (NMDA) were studied in the formalin test in mice. Both substances were administered 5 min before injection of formalin into the hind paw. Co-administration of substance P and NMDA intensified the response in both the 1st (0-10 min) and t...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(92)90260-I
更新日期：1992-11-01 00:00:00
abstract：:On a no treatment trial, a group of 24 oriental subjects rated cold pressor pain as significantly more painful and distressing than did a group of 24 occidental subjects. For half of the Orientals and half of the Occidentals, a second trial was conducted after acupuncture analgesia had been induced. The remaining 12 O...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(77)90086-0
更新日期：1977-10-01 00:00:00
abstract：:Sensitization of purinergic P2X3 receptors (P2X3Rs) is a major mechanism contributing to injury-induced exaggerated pain responses. We showed in a previous study that cyclic adenosine monophosphate (cAMP)-dependent guanine nucleotide exchange factor 1 (Epac1) in rat sensory dorsal root ganglia (DRGs) is upregulated af...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000547
更新日期：2016-07-01 00:00:00
abstract：:Network meta-analysis uses direct comparisons of interventions within randomized controlled trials and indirect comparisons across them. Network meta-analysis uses more data than a series of direct comparisons with placebo, and theoretically should produce more reliable results. We used a Cochrane overview review of a...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1097/j.pain.0000000000001322
更新日期：2018-11-01 00:00:00
abstract：:Previous studies have shown that the peripheral nerve regeneration process is linked to pain in several neuropathic pain models. Other studies show that sympathetic blockade may relieve pain in some pain models and clinical conditions. This study examined reduction in peripheral nerve regeneration as one possible mech...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001887
更新日期：2020-08-01 00:00:00
abstract：:We compared patient-controlled analgesia (PCA) and continuous infusion (CI) morphine delivery in a randomized controlled trial in adolescents during oropharyngeal mucositis pain after bone marrow transplantation. Results from 20 patients who completed 7 or more days on study (10 PCA, 10 CI) were evaluated. The group m...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(91)90109-B
更新日期：1991-09-01 00:00:00
abstract：:The present paper describes the pain reducing effect of high and low frequency transcutaneous electrical nerve stimulation (TENS) and 100 Hz mechanical vibratory stimulation as compared to placebo stimulation of the HoKu point in 50 patients suffering acute oro-facial pain. Ten of the 30 patients receiving actual stim...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(85)90100-9
更新日期：1985-11-01 00:00:00
abstract：:To quantify performance differences between patients with low-back pain (LBP) and a control group during their performance of a repetitive isodynamic lifting task. Case-control study was done. LBP patients were recruited and tested at an outpatient ambulatory chronic pain rehabilitation program before treatment was be...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(03)00247-1
更新日期：2003-09-01 00:00:00
abstract：:Using the chronic constriction injury (CCI) model of neuropathic pain, we profiled gene expression in the rat spinal cord, and identified SIP30 as a gene whose expression was elevated after CCI. SIP30 was previously shown to interact with SNAP25, but whose function was otherwise unknown. We now show that in the spinal...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.07.011
更新日期：2009-11-01 00:00:00
abstract：:The synaptic vesicle protein synapsin II plays an important role in the regulation of neurotransmitter release and synaptic plasticity. Here, we investigated its involvement in the synaptic transmission of nociceptive signals in the spinal cord and the development of pain hypersensitivity. We show that synapsin II is ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2005.02.027
更新日期：2005-05-01 00:00:00
abstract：:Musculoskeletal disorders (MSDs) are highly prevalent, painful, and costly disorders. The MSD Cohort was created to characterize variation in pain, comorbidities, treatment, and outcomes among patients with MSD receiving Veterans Health Administration care across demographic groups, geographic regions, and facilities....
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000567
更新日期：2016-08-01 00:00:00
abstract：:Neuropathic pain (NP) in cancer patients lacks standards for diagnosis. This study is aimed at reaching consensus on the application of the International Association for the Study of Pain (IASP) special interest group for neuropathic pain (NeuPSIG) criteria to the diagnosis of NP in cancer patients and on the relevanc...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2014.09.038
更新日期：2014-12-01 00:00:00
