Anterior nucleus of paraventricular thalamus mediates chronic mechanical hyperalgesia.

abstract：:Human experimental pain models are widely used to study drug effects under controlled conditions, but they require further optimization to better reflect clinical pain conditions. To this end, we measured experimentally induced pain in 110 (46 men) healthy volunteers. The quantitative sensory testing (QST) battery (Ge...

journal_title：Pain

authors： Lötsch J,Dimova V,Hermens H,Zimmermann M,Geisslinger G,Oertel BG,Ultsch A

更新日期：2015-03-01 00:00:00

abstract：:Pharmacological actions on the nociceptive flexion flexes of the hindlimb were investigated in 14 normal subjects. These reflexes were used as an index of pain and were recorded in the biceps femoris muscle, elicited by electrical stimulation of the ipsilateral sural nerve (RIII,su) and of the skin in the distal recep...

journal_title：Pain

authors： Willer JC,Bathien N

更新日期：1977-04-01 00:00:00

abstract：:Return of sensory nerve function in rat molars following cut or crush injury to the inferior alveolar nerve (IAN) was measured by observing the jaw opening reflex (JOR) response of the digastric muscle to electrical stimulation of individual molars or the gingiva. The IAN was injured from a lateral approach to the man...

journal_title：Pain

authors： Berger RL,Byers MR,Calkins DF

更新日期：1983-04-01 00:00:00

abstract：:In the present study 366 patients suffering acute or chronic musculoskeletal pain of different origin were given vibratory stimulation for the pain. Many of the patients had previously had treatments of various kinds without satisfactory relief. The effect of vibratory stimulation was assessed during and after stimula...

journal_title：Pain

authors： Lundeberg T,Nordemar R,Ottoson D

更新日期：1984-09-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a ubiquitous signal transduction regulator, and Hsp90 inhibitors are in clinical development as cancer therapeutics. However, there have been very few studies on the impact of Hsp90 inhibitors on pain or analgesia, a serious concern for cancer patients. We previously found that Hsp90 i...

journal_title：Pain

authors： Stine C,Coleman DL,Flohrschutz AT,Thompson AL,Mishra S,Blagg BS,Largent-Milnes TM,Lei W,Streicher JM

更新日期：2020-08-01 00:00:00

abstract：:Musculoskeletal disorders (MSDs) are highly prevalent, painful, and costly disorders. The MSD Cohort was created to characterize variation in pain, comorbidities, treatment, and outcomes among patients with MSD receiving Veterans Health Administration care across demographic groups, geographic regions, and facilities....

journal_title：Pain

authors： Goulet JL,Kerns RD,Bair M,Becker WC,Brennan P,Burgess DJ,Carroll CM,Dobscha S,Driscoll MA,Fenton BT,Fraenkel L,Haskell SG,Heapy AA,Higgins DM,Hoff RA,Hwang U,Justice AC,Piette JD,Sinnott P,Wandner L,Womack JA,Br

更新日期：2016-08-01 00:00:00

abstract：:Acute inflammation of the sigmoid wall was induced by perendoscopic injection of formalin (50 microliters, 5%) under brief anesthesia in rats. The procedure was followed by behavioral patterns that significantly differed from those in animals injected with isotonic saline instead of formalin. Analysis of the formalin-...

journal_title：Pain

authors： Miampamba M,Chéry-Croze S,Gorry F,Berger F,Chayvialle JA

更新日期：1994-06-01 00:00:00

abstract：:Bipolar intrapulpal stimulation was applied to human teeth using the same procedure as in animal experiments. The effects of variation of stimulus parameters on the quality of sensation were studied. A prepain sensation exists which cannot be explained by diffusion of the stimulus to periodontal tissues. When the inte...

journal_title：Pain

authors： Azerad J,Woda A

更新日期：1977-12-01 00:00:00

abstract：:The tricyclic antidepressant drugs (TCAs) are commonly used in the treatment of chronic, especially neuropathic, pain. We evaluated their possible effect on a new model of neuropathic pain-related behaviour induced by ligatures tied loosely around the common sciatic nerve. The effects of 3 TCAs with different monoamin...

journal_title：Pain

authors： Ardid D,Guilbaud G

更新日期：1992-05-01 00:00:00

abstract：:Wind-up and secondary hyperalgesia both are related to central sensitization, but whereas the former is explained by homosynaptic facilitation, the latter is due to heterosynaptic facilitation. To investigate possible interactions between both types of facilitation, we tested for alterations of perceptual wind-up in t...

journal_title：Pain

authors： Magerl W,Wilk SH,Treede RD

更新日期：1998-02-01 00:00:00

abstract：:The effect of different formalin concentrations on the nociceptive response in the formalin test was examined in mice. Subcutaneous formalin injection induces 2 distinct periods of high licking activity: an early phase lasting the first 5 min, and a late phase lasting 20-30 min after the injection. Formalin concentrat...

journal_title：Pain

authors： Rosland JH,Tjølsen A,Mæhle B,Hole K

更新日期：1990-08-01 00:00:00

abstract：:The effectiveness of a brief clinical and basic science seminar on pain for 1st year medical students was examined by comparing attitudes about pain prior to the seminar to attitudes 5 months after the seminar. The 6-h course combined written materials conveying facts about behavioral, social and biological aspects of...

journal_title：Pain

authors： Wilson JF,Brockopp GW,Kryst S,Steger H,Witt WO

更新日期：1992-09-01 00:00:00

abstract：:Nitric oxide (NO) acts as a neurotransmitter or neuromodulator involving in the modulation of thermal and/or inflammatory hyperalgesia. The neuronal nitric oxide synthase (nNOS) is a key enzyme for NO production in normal neuronal tissues, but its functional role in chronic pain remains unclear. The present study comb...

journal_title：Pain

authors： Chu YC,Guan Y,Skinner J,Raja SN,Johns RA,Tao YX

更新日期：2005-12-15 00:00:00

abstract：:In recent years, oxytocin has been implicated in a wide diversity of functions. The role of oxytocin in analgesia and pain modulation represents an important new function of an endogenous system controlling sensorial information. The paraventricular (PV) nucleus of the hypothalamus is one of the most important sources...

journal_title：Pain

authors： Miranda-Cardenas Y,Rojas-Piloni G,Martínez-Lorenzana G,Rodríguez-Jiménez J,López-Hidalgo M,Freund-Mercier MJ,Condés-Lara M

更新日期：2006-05-01 00:00:00

abstract：:We report findings from clinical examination and cutaneous laser stimulation in a 57-year-old male, who suffered from a right-sided postcentral stroke. In this patient, we were able to demonstrate (i) a dissociation of discriminative and affective components of pain perception and, for the first time in humans, (ii) t...

journal_title：Pain

authors： Ploner M,Freund HJ,Schnitzler A

更新日期：1999-05-01 00:00:00

abstract：:The present report describes a nation-wide survey on the incidence, the indications and the efficacy of spinal cord stimulation (SCS), as assessed by the Belgian health authorities. The direct motive for this survey was the rapidly growing expenditures resulting from the increasing use of SCS. Between 1983 and 1992, n...

journal_title：Pain

authors： Kupers RC,Van den Oever R,Van Houdenhove B,Vanmechelcn W,Hepp B,Nuttin B,Gybels JM

更新日期：1994-02-01 00:00:00

abstract：:Mechanisms of chronic pain, including neuropathic pain, are poorly understood. Upregulation of voltage-gated calcium channel (VGCC) alpha2delta1 subunit (Ca(v)alpha2delta1) in sensory neurons and dorsal spinal cord by peripheral nerve injury has been suggested to contribute to neuropathic pain. To investigate the mech...

journal_title：Pain

authors： Li CY,Zhang XL,Matthews EA,Li KW,Kurwa A,Boroujerdi A,Gross J,Gold MS,Dickenson AH,Feng G,Luo ZD

更新日期：2006-11-01 00:00:00

abstract：:Activation of supraspinal gamma-aminobutyric acid-A (GABAA) receptors is known to result in antagonism of opioid analgesia. Since benzodiazepines enhance the action of GABA at GABAA receptors, we hypothesized that administration of these agents for preoperative sedation might antagonize the analgesic effects of opioid...

journal_title：Pain

authors： Gear RW,Miaskowski C,Heller PH,Paul SM,Gordon NC,Levine JD

更新日期：1997-05-01 00:00:00

abstract：:Attenuation of neuropathic manifestations in experimental animals, by lidocaine injection in the rostral ventro-medial medulla (RVM), has been traditionally attributed to selective block of a descending pain facilitatory system. However, the presence of descending fibers carrying this effect and the selective action o...

journal_title：Pain

authors： Saadé NE,Al Amin H,Tchachaghian S,Jabbur SJ,Atweh SF

更新日期：2010-04-01 00:00:00

abstract：:Genetic polymorphisms result in absent enzyme activity of CYP2D6 (poor metabolizers, PM) in about 10% of the Caucasian population. This study investigates whether the PM genotype has an impact on the response to tramadol analgesia in postoperative patients. A prospective study design was used and 300 patients recoveri...

journal_title：Pain

authors： Stamer UM,Lehnen K,Höthker F,Bayerer B,Wolf S,Hoeft A,Stuber F

更新日期：2003-09-01 00:00:00

abstract：:Tanezumab is a humanized monoclonal antinerve growth factor antibody in development for treatment of chronic pain. In a phase III, placebo- and active-controlled study, we investigated the efficacy and safety of tanezumab for osteoarthritis (OA) hip or knee pain. Patients (N=610) received up to 2 doses of intravenous ...

journal_title：Pain

authors： Spierings ELH,Fidelholtz J,Wolfram G,Smith MD,Brown MT,West CR

更新日期：2013-09-01 00:00:00

abstract：:Coping with the demands of pain diminishes self-regulatory capacity and causes self-regulatory fatigue, which then leads to deteriorated executive task performance. It has been suggested that optimism can counteract the depletion of self-regulatory capacity. This study employed a 2 (optimism/no optimism)×2 (pain/no pa...

journal_title：Pain

authors： Boselie JJLM,Vancleef LMG,Smeets T,Peters ML

更新日期：2014-02-01 00:00:00

abstract：:Although perceived control has been used as a means of reducing the reaction to pain, conceptually, much is still unclear. The purpose of this study was to clarify the effects of control as a mediating variable in the reaction to pain as a function of the predispositional variables of perceived self-efficacy and trait...

journal_title：Pain

authors： Weisenberg M,Wolf Y,Mittwoch T,Mikulincer M,Aviram O

更新日期：1985-10-01 00:00:00

abstract：:This report describes a placebo-controlled study of transcutaneous electrical nerve stimulation (TENS) applied to the contralateral lower leg and outer ears of an amputee with non-painful phantom sensations. The subject received TENS or placebo stimulation on separate sessions in which baseline periods of no stimulati...

journal_title：Pain

authors： Katz J,France C,Melzack R

更新日期：1989-03-01 00:00:00

abstract：:Cognitions and beliefs appear important in predicting adjustment to chronic pain. The current study examines how cognitions and beliefs are related to psychosocial functioning. One hundred and sixty-three chronic pain out-patients were assessed. Regression analyses were performed using scores on the Pain Beliefs and P...

journal_title：Pain

authors： Stroud MW,Thorn BE,Jensen MP,Boothby JL

更新日期：2000-02-01 00:00:00

abstract：:Many malignant cancers, including breast cancer, have a propensity to invade bones, leading to excruciating bone pain. Opioids are the primary analgesics used to alleviate this cancer-induced bone pain (CIBP) but are associated with numerous severe side effects, including enhanced bone degradation, which significantly...

journal_title：Pain

authors： Zhang H,Lund DM,Ciccone HA,Staatz WD,Ibrahim MM,Largent-Milnes TM,Seltzman HH,Spigelman I,Vanderah TW

更新日期：2018-09-01 00:00:00

abstract：:There is extensive evidence that spinal excitatory amino acids (EAAs) like glutamate (Glu) and aspartate (Asp) are important in the processing of nociceptive behaviors caused by incisions. To better understand EAA-induced dorsal horn sensitization caused by surgery, we examined the time course and extent of spinal ami...

journal_title：Pain

authors： Zahn PK,Sluka KA,Brennan TJ

更新日期：2002-11-01 00:00:00

abstract：:This article reports on a study that examines the influence of task-related factors on nurses' pain assessments and decision regarding interventions. In an experimental design pediatric nurses (n = 202), were exposed to different cases, each case being a combination of a vignette and a videotape. For every case subjec...

journal_title：Pain

authors： Hamers JPH,Abu-Saad HH,van den Hout MA,Halfens RJG,Kester ADM

更新日期：1996-04-01 00:00:00

abstract：:A controlled trial of diamorphine (diacetylmorphine, heroin) and morphine is reported in which the two drugs were administered regularly by mouth in individually determined effective analgesic doses. Elixirs contained cocaine hydrochloride 10 mg/dose; other drugs were prescribed when indicated clinically. 699 patients...

journal_title：Pain

authors： Twycross RG

更新日期：1977-04-01 00:00:00

abstract：:Temporomandibular disorders (TMD) represent a group of chronic painful conditions involving the muscles of mastication and the temporomandibular joint. Several studies have reported that TMD is associated with enhanced sensitivity to experimental pain. Twenty-three TMD subjects and 24 pain-free matched control subject...

journal_title：Pain

authors： Maixner W,Fillingim R,Sigurdsson A,Kincaid S,Silva S

更新日期：1998-05-01 00:00:00