Reduced pain-related behavior by adrenal medullary transplants in rats with experimental painful peripheral neuropathy.

abstract：:Opiate-adrenergic interactions were investigated by studying the effect of the selective alpha 2-adrenergic agonist, clonidine, on the analgesia produced by intravenous placebo and by the predominantly kappa-opiate agonist, pentazocine, in patients with dental postoperative pain. Clonidine did not affect the pain leve...

journal_title：Pain

authors： Gordon NC,Heller PH,Levine JD

更新日期：1992-02-01 00:00:00

abstract：:Altogether 553 children (195 first graders, mean age 6.8 years, and 358 third graders, mean age 8.7 years) participated in the development of a self-report measure to assess the intensity of children's pain. The first step was the derivation, from children's drawings of facial expressions of pain, of 5 sets of 7 schem...

journal_title：Pain

authors： Bieri D,Reeve RA,Champion DG,Addicoat L,Ziegler JB

更新日期：1990-05-01 00:00:00

abstract：:Complex regional pain syndrome (CRPS) is a painful condition affecting one or more extremities of the body, marked by a wide variety of symptoms and signs that are often difficult to manage because the pathophysiology is incompletely understood. Thus, diverse treatments might be ineffective. A recent report revealed t...

journal_title：Pain

authors： Kohr D,Singh P,Tschernatsch M,Kaps M,Pouokam E,Diener M,Kummer W,Birklein F,Vincent A,Goebel A,Wallukat G,Blaes F

更新日期：2011-12-01 00:00:00

abstract：:The social determinants of health (SDH) are known to differentially impact outcomes from many noncommunicable diseases; however, their potential role in low back pain (LBP) is poorly defined. This review endeavours to comprehensively inform the field of their relevance. Our research question was: "How do the broad ran...

journal_title：Pain

authors： Karran EL,Grant AR,Moseley GL

更新日期：2020-11-01 00:00:00

abstract：:Pain is a complex human trait. It is likely that the interaction of multiple genes, each with a small individual effect, along with the effect of environmental factors, influences the clinical efficacy of opioids rather than a single gene alone. Polymorphisms in genes coding for the mu-opioid receptor (A118G) and cate...

journal_title：Pain

authors： Reyes-Gibby CC,Shete S,Rakvåg T,Bhat SV,Skorpen F,Bruera E,Kaasa S,Klepstad P

更新日期：2007-07-01 00:00:00

abstract：:A noxious cold stimulus can evoke multiple sensations each occurring with a different time course. We have performed psychophysical studies to identify the time course of five sensations evoked by a noxious cold stimulus applied to the hand. Subjects continuously rated either pain, ache, cold, heat or prickle sensatio...

journal_title：Pain

authors： Davis KD,Pope GE

更新日期：2002-07-01 00:00:00

abstract：:In primary care and physical therapy settings, we evaluated an intervention for chronic back pain patients which incorporated fear reducing and activating techniques. Primary care patients seen for back pain in primary care were screened to identify persons with significant activity limitations 8-10 weeks after their ...

journal_title：Pain

authors： Von Korff M,Balderson BHK,Saunders K,Miglioretti DL,Lin EHB,Berry S,Moore JE,Turner JA

更新日期：2005-02-01 00:00:00

abstract：:Central pain following traumatic brain injury (TBI) has not been studied in depth. Our purpose was to conduct a systematic study of patients with TBI suffering from chronic central pain, and to describe the characteristics of the central pain. Groups were TBI patients with (TBIP) and without central pain (TBINP) and h...

journal_title：Pain

authors： Ofek H,Defrin R

更新日期：2007-10-01 00:00:00

abstract：:Two hundred and sixty-three ambulatory patients older than 21 years of age who were attending clinics at an oncology hospital in San Juan, Puerto Rico, were studied. They completed a questionnaire (BQ-PR) that measures 8 concerns about reporting pain and using analgesics, such as fears of addiction and tolerance and t...

journal_title：Pain

authors： Ward SE,Hernandez L

更新日期：1994-08-01 00:00:00

abstract：:Indicators of persistent pain in preterm neonates are poorly defined. In the setting of a double blind, placebo-controlled trial investigating morphine use in ventilated preterm infants (NEOPAIN Trial) we aimed to identify factors that may be useful in assessing persistent pain. Twenty-two babies (morphine 12; placebo...

journal_title：Pain

authors： Boyle EM,Freer Y,Wong CM,McIntosh N,Anand KJ

更新日期：2006-09-01 00:00:00

abstract：:Non-cardiac chest pain (NCCP) is a common and distressing condition. Prior studies suggest that psychotropic medication or pain coping skills training (CST) may benefit NCCP patients. To our knowledge, no clinical trials have examined the separate and combined effects of CST and psychotropic medication in the manageme...

journal_title：Pain

authors： Keefe FJ,Shelby RA,Somers TJ,Varia I,Blazing M,Waters SJ,McKee D,Silva S,She L,Blumenthal JA,O'Connor J,Knowles V,Johnson P,Bradley L

更新日期：2011-04-01 00:00:00

abstract：:Endogenous pain inhibition is less efficient in chronic pain patients. Diffuse noxious inhibitory control (DNIC), a form of endogenous pain inhibition, is compromised in women and older people, making them more vulnerable to chronic pain. However, the underlying mechanisms remain unclear. Here, we used a capsaicin-ind...

journal_title：Pain

authors： Da Silva JT,Tricou C,Zhang Y,Seminowicz DA,Ro JY

更新日期：2020-06-01 00:00:00

abstract：:The existence of prostaglandin (PG) receptors in the spinal cord has been demonstrated, but their role in sensory processing is not yet well defined. PGE1 is widely used clinically as a vasodilator. The present study was designed to investigate the effects of intrathecally administered PGE1 on the transmission of diff...

journal_title：Pain

authors： Saito Y,Kaneko M,Kirihara Y,Kosaka Y,Collins JG

更新日期：1995-12-01 00:00:00

abstract：:Postherpetic neuralgia (PHN) is a debilitating chronic pain condition, yet there is a lack of knowledge regarding underlying brain activity. Here we identify brain regions involved in spontaneous pain of PHN (n=11) and determine its modulation with Lidoderm therapy (patches of 5% lidocaine applied to the PHN affected ...

journal_title：Pain

authors： Geha PY,Baliki MN,Chialvo DR,Harden RN,Paice JA,Apkarian AV

更新日期：2007-03-01 00:00:00

abstract：:Monoclonal antibodies against GD(2) ganglioside, such as ch14.18, the human-mouse chimeric antibody, have been shown to be effective for the treatment of neuroblastoma. However, treatment is associated with generalized, relatively opiate-resistant pain. We investigated if a point mutation in ch14.18 antibody (hu14.18K...

journal_title：Pain

authors： Sorkin LS,Otto M,Baldwin WM 3rd,Vail E,Gillies SD,Handgretinger R,Barfield RC,Yu HM,Yu AL

更新日期：2010-04-01 00:00:00

abstract：:Intradental nerve activity (INA) induced by cold stimulation of human teeth is regularly accompanied by pain perception. In this study a mathematical model was developed in order to quantify the relationship between INA and pain. In 5 patients (45 experiments) INA was recorded using electrodes implanted in lower incis...

journal_title：Pain

authors： Fors U,Ahlquist ML,Skagerwall R,Edwall LGA,Haegerstam GAT

更新日期：1984-04-01 00:00:00

abstract：:The purpose of this study was to determine if some commonly used admission variables could predict treatment outcome on a multidisciplinary pain center. Specifically, it was designed as a prospective study of an index proposed by Maruta et al. The subjects were 104 patients. The 4 outcome measures used were staff judg...

journal_title：Pain

authors： Aronoff GM,Evans WO

更新日期：1982-09-01 00:00:00

abstract：:Hydromorphone is an alternative to morphine for intrathecal drug delivery system to treat refractory cancer pain; however, there is not enough clinical evidence to prove it. In our study, 233 patients from 12 different pain management centers across China were enrolled, 121 and 112 in the intrathecal hydromorphone (IT...

journal_title：Pain

authors： Ma K,Jin Y,Wang L,Feng ZY,Song T,Yang XQ,Chen FQ,Duan BL,Huang YQ,Xie GL,Bao HG,Wang K,Xu JT,Lu Y,Liu YQ

更新日期：2020-11-01 00:00:00

abstract：:Recent studies indicate that reactive oxygen species (ROS) play an important role in neuropathic pain, predominantly through spinal mechanisms. Since the data suggest that ROS are involved in central sensitization, the present study examines the levels of activated N-methyl-d-aspartate (NMDA) receptors in the dorsal h...

journal_title：Pain

authors： Gao X,Kim HK,Mo Chung J,Chung K

更新日期：2007-10-01 00:00:00

abstract：:A fundamental question for placebo research is whether such responses are a predisposition, quantifiable by brain characteristics. We examine this issue in chronic back pain (CBP) patients who participated in a double-blind brain imaging (functional magnetic resonance imaging) clinical trial. We recently reported that...

journal_title：Pain

authors： Hashmi JA,Baria AT,Baliki MN,Huang L,Schnitzer TJ,Apkarian VA

更新日期：2012-12-01 00:00:00

abstract：:The role of prostanoids in nociception is well established. The headache eliciting effects of prostacyclin (prostaglandin I(2), (PGI(2))) and its possible mechanisms had previously not been systematically studied in man. We hypothesized that infusion of PGI(2) might induce headache and vasodilatation of cranial vessel...

journal_title：Pain

authors： Wienecke T,Olesen J,Oturai PS,Ashina M

更新日期：2008-09-30 00:00:00

abstract：:Data from the World Health Organization's study of psychological problems in general health care were used to examine the course of persistent pain syndromes among primary care patients. Across 15 sites in 14 countries, 3197 randomly selected primary care patients completed baseline and 12-month follow-up assessments ...

journal_title：Pain

authors： Gureje O,Simon GE,Von Korff M

更新日期：2001-05-01 00:00:00

abstract：:This study critically examines the reported exercise-induced analgesia effect in view of the potential stress-induced analgesia of pain testing itself. Two designs were used to test whether previous findings of analgesia were induced by the exercise procedures or by the stress of the pain testing procedures themselves...

journal_title：Pain

authors： Padawer WJ,Levine FM

更新日期：1992-02-01 00:00:00

abstract：:In this review, the effectiveness of behavioral and pharmacological treatments for pediatric migraine was quantitatively summarized following the meta-analytic approach outlined by Hedges and Olkin (1985). A first meta-analysis based on treatment outcome within treatment conditions revealed that thermal biofeedback an...

journal_title：Pain

authors： Hermann C,Kim M,Blanchard EB

更新日期：1995-03-01 00:00:00

abstract：:The National Institutes of Health released the trial registry ClinicalTrials.gov in 2000 to increase public reporting and clinical trial transparency. This systematic review examined whether registered primary outcome specifications (POS; ie, definitions, timing, and analytic plans) in analgesic treatment trials corre...

journal_title：Pain

authors： Smith SM,Wang AT,Pereira A,Chang DR,McKeown A,Greene K,Rowbotham MC,Burke LB,Coplan P,Gilron I,Hertz SH,Katz NP,Lin AH,McDermott MP,Papadopoulos EJ,Rappaport BA,Sweeney M,Turk DC,Dworkin RH

更新日期：2013-12-01 00:00:00

abstract：:Many treatments used for women with vulvodynia are based solely upon expert opinion. This randomized trial aimed to test the relative efficacy of cognitive-behavioral therapy (CBT) and supportive psychotherapy (SPT) in women with vulvodynia. Of the 50 participants, 42 (84%) completed 10-week treatments and 47 (94%) co...

journal_title：Pain

authors： Masheb RM,Kerns RD,Lozano C,Minkin MJ,Richman S

更新日期：2009-01-01 00:00:00

abstract：:Chronic pain due to surgery, radiotherapy, or chemotherapy is prevalent in long-term cancer survivors. Chronic pain due to successful cancer treatment should be treated as chronic nonmalignant pain, primarily with nonpharmacological strategies. Based on complete national data from the Cancer Registry of Norway and the...

journal_title：Pain

authors： Fredheim OM,Skurtveit S,Handal M,Hjellvik V

更新日期：2019-04-01 00:00:00

abstract：:Five hundred consecutive patients attending a psychiatric clinic were examined in order to ascertain the prevalence of chronic pain in various psychiatric illnesses and demographic categories. Chronic pain was found to be a frequent symptom in anxiety neurosis (60%), neurotic depression (45%) and hysteria (24.3%). Les...

journal_title：Pain

authors： Chaturvedi SK

更新日期：1987-05-01 00:00:00

abstract：:One year follow-up data are analyzed for the effects of using transcutaneous neurostimulators on patients with chronic benign pain. Those who have successful surgery for pain relief have lower pain and analgesic intake levels than those who supplement their surgery with neurostimulation. Those who do not receive surge...

journal_title：Pain

authors： Sternbach RA,Ignelzi RJ,Deems LM,Timmermans G

更新日期：1976-03-01 00:00:00

abstract：:A mounting body of literature recommends that treatment for fibromyalgia (FM) encompass medications, exercise and improvement of coping skills. However, there is a significant gap in determining an effective counterpart to pharmacotherapy that incorporates both exercise and coping. The aim of this randomized controlle...

journal_title：Pain

authors： Carson JW,Carson KM,Jones KD,Bennett RM,Wright CL,Mist SD

更新日期：2010-11-01 00:00:00