Abstract:
:Transcutaneous nerve stimulation (TENS) treatment was given for 30 min to 37 patients divided into 3 groups of 10 patients and 1 group of 7 patients. Two groups received low-frequency (2 Hz) and the other 2 groups high-frequency (100 Hz) stimulation. A diagnostic lumbar cerebrospinal fluid (CSF) sample was obtained immediately before and after stimulation. The CSF samples were subjected to analysis of immunoreactive (ir) opioid peptides, Met-enkephalin-Arg-Phe (MEAP) from preproenkephalin and dynorphin A (Dyn A) from preprodynorphin, respectively. Low frequency TENS applied on the hand and the leg resulted in a marked increase (367%, P less than 0.05) of ir-MEAP but not ir-Dyn A, whereas high-frequency (100 Hz) TENS produced a 49% increase in ir-Dyn A (P less than 0.01) but not ir-MEAP. This is the first report in humans that 2 Hz and 100 Hz peripheral stimulation induces differential release of peptides from preproenkephalin and preprodynorphin, respectively.
journal_name
Painjournal_title
Painauthors
Han JS,Chen XH,Sun SL,Xu XJ,Yuan Y,Yan SC,Hao JX,Terenius Ldoi
10.1016/0304-3959(91)90218-Msubject
Has Abstractpub_date
1991-12-01 00:00:00pages
295-298issue
3eissn
0304-3959issn
1872-6623pii
00006396-199112000-00004journal_volume
47pub_type
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