Abstract：
:In a double-blind, crossover study, the effects of 75 mg amitriptyline alone during 5 weeks on pain intensity were compared with the effects of a combination of 75 mg amitriptyline and 3 mg flupentixol during 5 weeks in 34 patients with somatoform pain disorder. Both treatments resulted in a statistically significant reduction in pain. However, pain reduction in the combined treatment did not differ from that in the treatment with amitriptyline as a single drug. Neither tardive dyskinesias nor other serious side effects were observed. The results do not support the clinical practice of adding low-dose neuroleptics to low-dose antidepressants in the treatment of somatoform pain disorder.
journal_name
Painjournal_title
Painauthors
Zitman FG,Linssen ACG,Edelbroek PM,Van Kempen GMJdoi
10.1016/0304-3959(91)90007-Ksubject
Has Abstractpub_date
1991-10-01 00:00:00pages
25-30issue
1eissn
0304-3959issn
1872-6623pii
00006396-199110000-00006journal_volume
47pub_type
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