Mu- and delta-opioid receptors are downregulated in the largest diameter primary sensory neurons during postnatal development in rats.

abstract：:An evaluation of the analgesic, mood and side effects of the combination of intramuscular morphine and oral cocaine was conducted in 17 patients with postoperative pain and 19 others with chronic malignant pain for the purpose of assessing the therapeutic merits of so-called 'euphoriant' elixirs in the management of p...

journal_title：Pain

authors： Kaiko RF,Kanner R,Foley KM,Wallenstein SL,Canel AM,Rogers AG,Houde RW

更新日期：1987-10-01 00:00:00

abstract：:The present paper describes the pain reducing effect of high and low frequency transcutaneous electrical nerve stimulation (TENS) and 100 Hz mechanical vibratory stimulation as compared to placebo stimulation of the HoKu point in 50 patients suffering acute oro-facial pain. Ten of the 30 patients receiving actual stim...

journal_title：Pain

authors： Ekblom A,Hansson P

更新日期：1985-11-01 00:00:00

abstract：:This study characterized the pain reported in a selected group of obstetrical patients in labor and compared the pain experienced at 2 stages of dilation, dilation of 2-5 cm and of 6-10 cm. Pain was defined as the perception of an unpleasant sensory and emotional experience with multidimensional factors that evoke beh...

journal_title：Pain

authors： Brown ST,Campbell D,Kurtz A

更新日期：1989-09-01 00:00:00

abstract：:The enzyme 3alpha-hydroxysteroid oxido-reductase (3alpha-HSOR) catalyzes the synthesis and bioavailability of 3alpha,5alpha-neurosteroids as allopregnanolone (3alpha,5alpha-THP) which activates GABA(A) receptors and blocks T-type calcium channels involved in pain mechanisms. Here, we used a multidisciplinary approach ...

journal_title：Pain

authors： Patte-Mensah C,Meyer L,Schaeffer V,Mensah-Nyagan AG

更新日期：2010-09-01 00:00:00

abstract：:This experiment had three goals: 1. To identify the basis of sucking-induced analgesia in healthy, term, newborn humans undergoing the painful, routine, procedure of heel lance and blood collection. 2. To evaluate how taste-induced and sucking-induced analgesias combine to combat pain. 3. To determine whether facial g...

journal_title：Pain

authors： Blass EM,Watt LB

更新日期：1999-12-01 00:00:00

abstract：:Behavioral studies have suggested that placebo analgesia is partly mediated by the endogenous opioid system. Expanding on these results we have shown that the opioid-receptor-rich rostral anterior cingulate cortex (rACC) is activated in both placebo and opioid analgesia. However, there are also differences between the...

journal_title：Pain

authors： Petrovic P,Kalso E,Petersson KM,Andersson J,Fransson P,Ingvar M

更新日期：2010-07-01 00:00:00

abstract：:Alterations in sensory processing have been demonstrated in chronic low back and neck pain. However, it has not been yet systematically summarized how early these changes occur in spinal pain. This systematic review examines the available literature measuring somatosensory function in acute (<6 weeks) and subacute (6-...

journal_title：Pain

authors： Marcuzzi A,Dean CM,Wrigley PJ,Hush JM

更新日期：2015-02-01 00:00:00

abstract：:Long-term potentiation (LTP) in wide dynamic range (WDR) neurons in the dorsal horn has been suggested to contribute to central sensitization and the development of chronic pain. Indirect experimental evidence indicates an involvement of substance P (SP), in this respect. The aim of the present study was to monitor th...

journal_title：Pain

authors： Afrah AW,Fiskå A,Gjerstad J,Gustafsson H,Tjølsen A,Olgart L,Stiller CO,Hole K,Brodin E

更新日期：2002-03-01 00:00:00

abstract：:There is extensive evidence that spinal excitatory amino acids (EAAs) like glutamate (Glu) and aspartate (Asp) are important in the processing of nociceptive behaviors caused by incisions. To better understand EAA-induced dorsal horn sensitization caused by surgery, we examined the time course and extent of spinal ami...

journal_title：Pain

authors： Zahn PK,Sluka KA,Brennan TJ

更新日期：2002-11-01 00:00:00

abstract：:The relationship between subjective measurements of pain (pain report and threshold of sensation) and evoked potentials following painful electrical stimulation of tooth pulp was evaluated after intake of different weak analgesics. These time-response curves for the dolorimetric parameters were correlated to the in vi...

journal_title：Pain

authors： Rohdewald P,Derendorf H,Drehsen G,Elger CE,Knoll O

更新日期：1982-04-01 00:00:00

abstract：:We studied whether striatal alpha(2)-adrenoceptors or N-methyl-d-aspartate (NMDA) receptors influence descending regulation of neuropathic hypersensitivity in the rat by microinjecting an alpha(2)-adrenoceptor agonist or NMDA-receptor antagonist into the dorsal striatum in animals with a spinal nerve ligation-induced ...

journal_title：Pain

authors： Pertovaara A,Wei H

更新日期：2008-07-01 00:00:00

abstract：:Clinical trials on the treatment of pain syndromes have adopted Patient Global Impression of Change (PGIC) as a primary outcome. However, little is known about how change in clinical status influences these ratings. The present study examined relationships between changes in pain, depressed mood, physical functioning,...

journal_title：Pain

authors： Geisser ME,Clauw DJ,Strand V,Gendreau MR,Palmer R,Williams DA

更新日期：2010-05-01 00:00:00

abstract：:Venlafaxine hydrochloride (Effexor) is a structurally novel antidepressant that inhibits reuptake of 5-hydroxytryptamine and noradrenaline, but unlike the older antidepressants, has few side-effects. The objective of this study was to determine whether venlafaxine relieves thermal hyperalgesia in rats with neuropathic...

journal_title：Pain

authors： Lang E,Hord HA,Denson D

更新日期：1996-11-01 00:00:00

abstract：:We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) ...

journal_title：Pain

authors： Eccleston C,Fisher E,Cooper TE,Grégoire MC,Heathcote LC,Krane E,Lord SM,Sethna NF,Anderson AK,Anderson B,Clinch J,Gray AL,Gold JI,Howard RF,Ljungman G,Moore RA,Schechter N,Wiffen PJ,Wilkinson NMR,Williams DG,Wood

更新日期：2019-08-01 00:00:00

abstract：:It is well known that acupuncture has pain-relieving effects, but the contribution of specific and especially nonspecific factors to acupuncture analgesia is less clear. One hundred one patients who developed pain of ≥ 3 on a visual analog scale (VAS, 0 to 10) after third molar surgery were randomized to receive activ...

journal_title：Pain

authors： Vase L,Baram S,Takakura N,Yajima H,Takayama M,Kaptchuk TJ,Schou S,Jensen TS,Zachariae R,Svensson P

更新日期：2013-09-01 00:00:00

abstract：:Fifty-seven patients (74%) who had completed a multidisciplinary pain program returned mailed questionnaires assessing both outcome and compliance measures. Significant treatment gains were observed at follow-up. Compliance with prescribed therapeutic regimens was low, averaging around 42% for individual regimens. Com...

journal_title：Pain

authors： Lutz RW,Silbret M,Olshan N

更新日期：1983-11-01 00:00:00

abstract：:Heat and electrical detection thresholds were assessed in 72 patients suffering from painful temporomandibular disorder. Employing widely accepted criteria, 44 patients were classified as suffering from temporomandibular joint (TMJ) arthralgia (i.e. pain originating from the TMJ) and 28 from myalgia (i.e. pain origina...

journal_title：Pain

authors： Eliav E,Teich S,Nitzan D,El Raziq DA,Nahlieli O,Tal M,Gracely RH,Benoliel R

更新日期：2003-08-01 00:00:00

abstract：:Part I of our earlier pilot study demonstrated that patients preferred modulated stimulation forms - frequency modulation and burst - rather than conventional continuous mode. To assess whether long-term therapeutic effects validate the immediate test results, this trial was performed in 14 patients with 21 pain condi...

journal_title：Pain

authors： Tulgar M,McGlone F,Bowsher D,Miles JB

更新日期：1991-11-01 00:00:00

abstract：:In recent years, oxytocin has been implicated in a wide diversity of functions. The role of oxytocin in analgesia and pain modulation represents an important new function of an endogenous system controlling sensorial information. The paraventricular (PV) nucleus of the hypothalamus is one of the most important sources...

journal_title：Pain

authors： Miranda-Cardenas Y,Rojas-Piloni G,Martínez-Lorenzana G,Rodríguez-Jiménez J,López-Hidalgo M,Freund-Mercier MJ,Condés-Lara M

更新日期：2006-05-01 00:00:00

abstract：:Pain symptoms of many disorders are reported to vary with menstrual stage. This study investigated how pain thresholds to electrical stimulation of the skin, subcutis and muscle tissue varied with menstrual stage in normal women and compared these variations with those in women with dysmenorrhea and in healthy men at ...

journal_title：Pain

authors： Giamberardino MA,Berkley KJ,Iezzi S,de Bigontina P,Vecchiet L

更新日期：1997-06-01 00:00:00

abstract：:Altogether 553 children (195 first graders, mean age 6.8 years, and 358 third graders, mean age 8.7 years) participated in the development of a self-report measure to assess the intensity of children's pain. The first step was the derivation, from children's drawings of facial expressions of pain, of 5 sets of 7 schem...

journal_title：Pain

authors： Bieri D,Reeve RA,Champion DG,Addicoat L,Ziegler JB

更新日期：1990-05-01 00:00:00

abstract：:Monoclonal antibodies against GD(2) ganglioside, such as ch14.18, the human-mouse chimeric antibody, have been shown to be effective for the treatment of neuroblastoma. However, treatment is associated with generalized, relatively opiate-resistant pain. We investigated if a point mutation in ch14.18 antibody (hu14.18K...

journal_title：Pain

authors： Sorkin LS,Otto M,Baldwin WM 3rd,Vail E,Gillies SD,Handgretinger R,Barfield RC,Yu HM,Yu AL

更新日期：2010-04-01 00:00:00

abstract：:Bone is one of the leading sites of metastasis for frequently diagnosed malignancies, including those arising in the breast, prostate and lung. Although these cancers develop unnoticed and are painless in their primary sites, bone metastases result in debilitating pain. Deeper investigation of this pain may reveal eti...

journal_title：Pain

authors： Slosky LM,BassiriRad NM,Symons AM,Thompson M,Doyle T,Forte BL,Staatz WD,Bui L,Neumann WL,Mantyh PW,Salvemini D,Largent-Milnes TM,Vanderah TW

更新日期：2016-11-01 00:00:00

abstract：:Extraterritorial spread of sensory symptoms is frequent in carpal tunnel syndrome (CTS). Animal models suggest that this phenomenon may depend on central sensitization. We sought to obtain psychophysical evidence of sensitization in CTS with extraterritorial symptoms spread. We recruited 100 unilateral CTS patients. A...

journal_title：Pain

authors： Zanette G,Cacciatori C,Tamburin S

更新日期：2010-02-01 00:00:00

abstract：:We have examined the effects of cannabinoid agonists on hyperalgesia in a model of neuropathic pain in the rat and investigated the possible sites of action. The antihyperalgesic activity of the cannabinoids was compared with their ability to elicit behavioural effects characteristic of central cannabinoid activity. W...

journal_title：Pain

authors： Fox A,Kesingland A,Gentry C,McNair K,Patel S,Urban L,James I

更新日期：2001-05-01 00:00:00

abstract：:Pain scales using faces are commonly used tools for assessing pain in children capable of communicating. However, some children require other types of pain scales because they have difficulties in understanding faces pain scales. The goal of this study was to develop and validate the "Pain Block" concrete ordinal scal...

journal_title：Pain

authors： Jung JH,Lee JH,Kim DK,Jung JY,Chang I,Kwon H,Shin J,Paek SH,Oh S,Kwak YH

更新日期：2018-04-01 00:00:00

abstract：:Drawing on advances in chronic pain metrics, a simplified Graded Chronic Pain Scale-Revised was developed to differentiate mild, bothersome, and high-impact chronic pain. Graded Chronic Pain Scale-Revised was validated among adult enrollees of 2 health plans (N = 2021). In this population, the prevalence of chronic pa...

journal_title：Pain

authors： Von Korff M,DeBar LL,Krebs EE,Kerns RD,Deyo RA,Keefe FJ

更新日期：2020-03-01 00:00:00

abstract：:Total hindpaw denervation in rodents elicits an abnormal behavior of licking, scratching and self-injury of the anesthetic limb ("autotomy"). Since the same denervation produces phantom limb pain and anesthesia dolorosa in humans, autotomy has been used as a model of human neuropathic pain. Autotomy is an inherited tr...

journal_title：Pain

authors： Seltzer Z,Wu T,Max MB,Diehl SR

更新日期：2001-08-01 00:00:00

abstract：:The responses of preterm neonates to acute tissue-damaging stimuli have been described. However, factors which influence these responses have received little attention. In this study, we observed 124 premature infants before, during and after a routine heel lance and determined how two contextual variables (severity o...

journal_title：Pain

authors： Stevens BJ,Johnston CC,Horton L

更新日期：1994-10-01 00:00:00

abstract：:Unilateral intraplantar injection of Freund's complete adjuvant (FCA) into 1 hind paw of rats was used as a model of peripheral inflammation and persistent pain in order to examine time course effects of a continuous barrage of nociceptive input on the second-messenger transducing systems in the spinal cord. cAMP, cGM...

journal_title：Pain

authors： Igwe OJ,Li N

更新日期：1994-07-01 00:00:00