Abstract:
:The behavioral response to acute tissue injury is usually characterized by different phases, but the brain mechanisms underlying changes in pain-related behavior over time are still poorly understood. We aimed to analyze time-dependent changes in metabolic activity levels of 49 forebrain structures in the formalin pain model, using the autoradiographic 2-deoxyglucose method in unanesthetized, freely moving rats. We examined rats during the first phase of pain-related reactions ('early' groups), or during the third recovery phase, 60 min later, when the supraspinally mediated behavioral responses were reduced ('late' group). In the early groups, metabolic rates were bilaterally increased over control values in the periaqueductal gray, zona incerta and in several thalamic nuclei (anteroventral, centrolateral, lateral dorsal, parafascicular, posteromedial, submedius, ventromedial, and ventrobasal complex), as well as in the habenulae and in the parietal, cingulate, antero-dorsal insular, and anterior piriform cortex. A contralateral, somatotopically specific activation was found in the putative hindlimb representation area of the somatosensory cortex. In the late group, noxious-induced activation declined in most structures. However, metabolic rates were higher than controls in the periaqueductal gray and zona incerta and in two other structures not previously active: the prerubral area/field of Forel and the arcuate hypothalamic nucleus. These findings provide a time-dependent functional map of nociceptive and anti-nociceptive forebrain circuits during tonic pain. The parallel decrease in licking behavior and forebrain activity, at times when spinally mediated limb flexion responses were still present, suggests that endogenous antinociceptive systems may differently modulate spinal and supraspinal nociceptive networks following acute tissue injury.
journal_name
Painjournal_title
Painauthors
Porro CA,Cavazzuti M,Lui F,Giuliani D,Pellegrini M,Baraldi Pdoi
10.1016/s0304-3959(03)00015-0keywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
291-301issue
1-2eissn
0304-3959issn
1872-6623pii
S0304395903000150journal_volume
104pub_type
杂志文章相关文献
PAIN文献大全abstract::Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide assoc...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002100
更新日期:2020-09-30 00:00:00
abstract::The ability to sense visceral pain during appendicitis is diminished with age leading to delay in seeking health care and poorer clinical outcomes. To understand the mechanistic basis of this phenomenon, we examined visceral nociception in aged mouse and human tissue. Inflamed and noninflamed appendixes were collected...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001764
更新日期:2020-04-01 00:00:00
abstract:ABSTRACT:Spinal cord stimulation (SCS) is an approved treatment for truncal and limb neuropathic pain. However, pain relief is often suboptimal and SCS efficacy may reduce over time, requiring sometimes the addition of other pain therapies, stimulator revision, or even explantation. We designed and tested a new procedu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002160
更新日期:2020-11-30 00:00:00
abstract::Growing evidence suggests that leukocyte extravasation is initiated by the interaction of selectins with their ligands; as well as an essential role for P-selectin in the initial recruitment of inflammatory cells to sites of inflammation. In this study, P-selectin-deficient (P-sel-/-) mice were used to test the hypoth...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.06.042
更新日期:2013-10-01 00:00:00
abstract::The literature on cognitive and cognitive-behavioral methods for pain control is selectively reviewed, with particular focus on controlled studies. Such methods include the provision of preparatory information, cognitive coping skills or strategies, the provision of preparatory information plus some form of coping ski...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(82)90154-3
更新日期:1982-03-01 00:00:00
abstract::Disabling neuropathic pain (NeuP) is a common sequel of diabetic peripheral neuropathy (DPN). We aimed to characterise the sensory phenotype of patients with and without NeuP, assess screening tools for NeuP, and relate DPN severity to NeuP. The Pain in Neuropathy Study (PiNS) is an observational cross-sectional multi...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1097/j.pain.0000000000000491
更新日期:2016-05-01 00:00:00
abstract::Bipolar intrapulpal stimulation was applied to human teeth using the same procedure as in animal experiments. The effects of variation of stimulus parameters on the quality of sensation were studied. A prepain sensation exists which cannot be explained by diffusion of the stimulus to periodontal tissues. When the inte...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(77)90128-2
更新日期:1977-12-01 00:00:00
abstract::OnabotulinumtoxinA (onabotA) has shown efficacy in chronic migraine (CM). Its mechanism of action, however, remains obscure. We have analysed whether treatment with onabotA is able to induce changes in interictal plasma calcitonin gene-related peptide (CGRP) concentrations, which have been shown to be increased in pat...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000119
更新日期:2015-05-01 00:00:00
abstract::This study investigated the effects of a single administration of 6-(4-methoxyphenyl)-5-methyl-3-pyridinyl-4-isoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP), a negative allosteric modulator (NAM) of metabotropic glutamate receptor 7 (mGluR7), on pain and on affective and cognitive behavior in neuropathic mice. The activity ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000150
更新日期:2015-06-01 00:00:00
abstract::We investigated the effects of acute and of chronic morphine treatment on T-lymphocyte function and natural killer (NK) cell activity in rats receiving chronic constriction injury (CCI) of the sciatic nerve. T-Lymphocyte function was evaluated based on concanavalin-A (ConA)- and phytohemagglutinin (PHA)-induced spleno...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00323-7
更新日期:2000-11-01 00:00:00
abstract::The effectiveness of a brief clinical and basic science seminar on pain for 1st year medical students was examined by comparing attitudes about pain prior to the seminar to attitudes 5 months after the seminar. The 6-h course combined written materials conveying facts about behavioral, social and biological aspects of...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90028-A
更新日期:1992-09-01 00:00:00
abstract::Neuropathic pain may be produced, at least in part, by the increased activity of primary afferent neurons. Studies have suggested that an accumulation of voltage-gated sodium channels at the site of peripheral nerve injury is a primary precursory event for subsequent afferent hyperexcitability. In this study, a human ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00120-1
更新日期:1998-11-01 00:00:00
abstract::The existence of a pathophysiological link between tonic muscle activity and chronic muscle pain is still being debated. The purpose of this retrospective, controlled study was to evaluate the electromyographic (EMG) activity of masticatory muscles in subjects with different orofacial pain conditions. The temporal and...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.03.011
更新日期:2005-07-01 00:00:00
abstract::The present study sought to discover whether information clarifying how the analgesic/sedative drug nitrous oxide (N2O) works would result in increased analgesic responses to painful stimuli when various concentrations of N2O were administered. Subjects were provided with high and low levels of information regarding t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90080-0
更新日期:1984-08-01 00:00:00
abstract::To clarify the relationships between physical, and psychosocial components of chronic pain, a path analytic model was tested conceptualizing self efficacy as a mediator of disability. In turn, disability was hypothesized to mediate depression. This model could help explain the circumstances under which disability deve...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00220-6
更新日期:1999-04-01 00:00:00
abstract::Chronic dry eye disease (DE) is associated with an unstable tear film and symptoms of ocular discomfort. The characteristics of symptoms suggest a key role for central neural processing; however, little is known about central neuroplasticity and DE. We used a model for tear deficient DE and assessed effects on eye bli...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000135
更新日期:2015-05-01 00:00:00
abstract::Pain catastrophizing is associated with enhanced temporal summation of pain (TS-Pain). However, because prior studies have found that pain catastrophizing is not associated with a measure of spinal nociception (nociceptive flexion reflex [NFR] threshold), this association may not result from changes in spinal nocicept...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.12.041
更新日期:2011-04-01 00:00:00
abstract::Tolerance to the antinociceptive (analgesic) effect of morphine, a mu-opioid agonist, was developed in male CD-1 mice as assessed by a shift to the right of the analgesic (tail-flick) dose-response curves and an increase in the ED50 values. Administration of dextromethorphan at 30 mg/kg s.c., but not saline, 30 min pr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90022-1
更新日期:1994-12-01 00:00:00
abstract::Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.pain.2013.03.006
更新日期:2013-07-01 00:00:00
abstract::Previous studies have shown that the peripheral nerve regeneration process is linked to pain in several neuropathic pain models. Other studies show that sympathetic blockade may relieve pain in some pain models and clinical conditions. This study examined reduction in peripheral nerve regeneration as one possible mech...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001887
更新日期:2020-08-01 00:00:00
abstract::Genetics studies on the placebo hypoalgesic effect highlight a promising link between single nucleotide polymorphisms (SNPs) in the dopamine, opioid, and endocannabinoid genes and placebo hypoalgesia. However, epistasis and replication studies are missing. In this study, we expanded on previous findings related to the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001578
更新日期:2019-08-01 00:00:00
abstract::Clinicians use patients' recall of pain and disability relief as indicators of therapeutic effectiveness. Recall can change over time, however, and is influenced by factors other than true relief, including current health status. We have determined the trend in the relative contribution of current pain/disability and ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(01)00377-3
更新日期:2002-01-01 00:00:00
abstract::This study compared individuals with fibromyalgia (FM) and individuals with chronic low back pain (CLBP) on repetition-induced summation of activity-related pain (RISP). Fear of movement, pain catastrophizing and depression were examined as potential mediators of group differences. The sample consisted of 50 women wit...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.02.030
更新日期:2011-06-01 00:00:00
abstract::In rats anesthetized with sodium pentobarbital, we quantitatively analyzed descending modulation from the midbrain of a nociceptive flexion withdrawal reflex and responses of associated spinal neurons. We monitored the isometric force of hind limb withdrawal elicited by noxious heat stimuli (42-54 degrees C, 10 sec) o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90061-F
更新日期:1992-02-01 00:00:00
abstract::This study focuses on changes in adrenergic sensitivity in untransected sensory axons that innervate an area of skin made neuropathic by transection of neighboring nerves. The segmental nerve injury model is favorable for this since all axons in the L5 and L6 nerves are transected whereas the L4 axons are intact. Earl...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00252-8
更新日期:1999-04-01 00:00:00
abstract::Snakebites are a relevant public health problem in Central and South America. Snake bite envenomations cause intense pain, not relieved by anti-venom. The fangs of many species are short, causing subcutaneous injection. Fangs of larger species inflict subcutaneous or intramuscular envenomation. To understand pain indu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.06.001
更新日期:2004-09-01 00:00:00
abstract::According to fear-avoidance models, a catastrophic interpretation of a painful experience may give rise to pain-related fear and avoidance, leading to the development and maintenance of chronic pain problems in the long term. However, little is known about how exactly motivation and goal prioritization play a role in ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000116
更新日期:2015-08-01 00:00:00
abstract::To investigate the pathways of noxious information in the spinal cord in humans, we recorded cortical potentials following the stimulation of A-delta fibers using a YAG laser applied to two cutaneous points on the back at the C7 and Th10 level, 4cm to the right of the vertebral spinous process. A multiple source analy...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.03.009
更新日期:2006-08-01 00:00:00
abstract::Single units were recorded in dorsal roots or in the sciatic nerve of anaesthetised rats. It was shown by making sections, by stimulation and by collision that some ongoing nerve impulses were originating from the dorsal root ganglia and not from the central or peripheral ends of the axons. In a sample of 2731 intact ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90164-1
更新日期:1983-12-01 00:00:00
abstract::Neuropathic pain affects millions of people worldwide, causing substantial disability and greatly impairing quality of life. Commonly used analgesics or antihyperalgesic compounds are generally characterized by limited therapeutic outcomes. Thus, there is a compelling need for novel therapeutic strategies able to prev...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.06.023
更新日期:2014-10-01 00:00:00