Abstract：
:A descriptive, longitudinal design was used to examine changes in current, worst, and least pain intensity during hospitalization for a vaso-occlusive episode in children with sickle cell disease. Other dimensions of the pain experience including location and quality were also evaluated. Children reported severe pain on the day of admission with 50% of the episodes showing a current pain intensity score of >70 and a worst pain intensity score of >80. Although both pain intensity scores demonstrated statistically significant decreases by approximately 5% over the course of the hospitalization, these decreases were not clinically significant based on the recommendations made in the American Pain Society's Guideline for the management of acute and chronic pain in sickle cell disease. In contrast to the pain intensity ratings, which did not decrease in 25% of the episodes, pain location surface area decreased in 100% of the episodes. Children described the quality of vaso-occlusive pain using all categories of word descriptors from the adolescent pediatric pain tool. These findings suggest that pain associated with a vaso-occlusive episode is inadequately assessed and managed during hospitalization.
journal_name
Painjournal_title
Painauthors
Jacob E,Miaskowski C,Savedra M,Beyer JE,Treadwell M,Styles Ldoi
10.1016/s0304-3959(02)00374-3keywords:
subject
Has Abstractpub_date
2003-03-01 00:00:00pages
187-93issue
1-2eissn
0304-3959issn
1872-6623pii
S0304395902003743journal_volume
102pub_type
杂志文章相关文献
PAIN文献大全abstract：:A growing body of literature suggests that the experience of clinical pain differs across ethnocultural groups. Additionally, some evidence indicates greater sensitivity to experimentally induced pain among African Americans; however, most studies have included only one pain modality. This study examined ethnic differ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.08.013
更新日期：2005-01-01 00:00:00
abstract：:The purpose of this study was to examine the relationship between a mother's rating of her own and her child's anxiety and their observed behavior during an immunization. Eighty-three preschool children and their mothers were observed in a health screening clinic while the child received an immunization. Each mother w...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(89)90156-5
更新日期：1989-04-01 00:00:00
abstract：:Investigating protective strategies against chronic neuropathic pain (CNP) after breast cancer surgery entails using valid screening tools. The DN4 (Douleur Neuropathique en 4 questions) is 1 tool that offers important research advantages. This prospective 6-month follow-up study seeks to validate the DN4 and assess i...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1097/j.pain.0000000000000108
更新日期：2015-04-01 00:00:00
abstract：:Patients with schizophrenia report reduced pain sensitivity in clinical studies, but experimental studies are required to establish pain sensitivity as a potential endophenotype. We conducted a systematic review of electronic databases from database inception until April 15, 2015, including experimental studies invest...
journal_title：Pain
pub_type： 杂志文章,meta分析
doi：10.1097/j.pain.0000000000000304
更新日期：2015-11-01 00:00:00
abstract：:Pregnant women may take nonsteroidal antiinflammatory drugs (NSAIDs), selective cyclooxygenase (COX)-2 inhibitors, or biological agents to relieve symptoms or manage disease flares in late pregnancy. We aimed to quantify the risk of prematurity associated with late pregnancy exposure to nonselective NSAIDs, selective ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001163
更新日期：2018-05-01 00:00:00
abstract：:The results of a considerable number of recent prospective studies have demonstrated that greater acute pain severity in herpes zoster patients is associated with a significantly greater risk of developing postherpetic neuralgia (PHN). Only a few studies have examined the relationships between acute pain severity and ...
journal_title：Pain
pub_type： 杂志文章,meta分析
doi：10.1016/S0304-3959(01)00347-5
更新日期：2001-10-01 00:00:00
abstract：:Previous work has suggested an attenuated sensitivity to painful stimulation in hypertensive men. We recently reported that, compared with persons with negative parental history, men, but not women, with a positive history for hypertension showed attenuated pain perception. This study specifically addressed factors th...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(00)00306-7
更新日期：2000-10-01 00:00:00
abstract：:An empirical determination of the nature and minimum number of dimension necessary to describe responses to the McGill Pain Questionnaire, and a comparison of groups, experiencing clinical or experimentally induced pain, on the dimensions were carried out. Eighty-five patients referred to a low back pain diagnostic cl...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(77)90131-2
更新日期：1977-12-01 00:00:00
abstract：:Regular physical activity in healthy individuals prevents development of chronic musculoskeletal pain; however, the mechanisms underlying this exercise-induced analgesia are not well understood. Interleukin-10 (IL-10), an antiinflammatory cytokine that can reduce nociceptor sensitization, increases during regular phys...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000312
更新日期：2016-01-01 00:00:00
abstract：:Chronic low back pain (CLBP) and obesity are interrelated, but the physiological mechanisms linking the 2 conditions remain to be determined. Functional brain imaging data from CLBP patients show functional and structural alterations in areas mediating the attribution of hedonic value to food. Accordingly, we hypothes...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2013.12.027
更新日期：2014-04-01 00:00:00
abstract：:Pain modulation by placebo mechanisms is one of the most robust and best-studied phenomena, yet almost all research investigating the mechanisms and implications of the placebo analgesia are based on adult research. After highlighting crucial aspects that need to be considered in studying pain modulation in children, ...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1016/j.pain.2014.08.036
更新日期：2014-11-01 00:00:00
abstract：:Blockade of the noradrenergic input to the nucleus raphe magnus (NRM) by the injection of alpha-adrenergic antagonists produces hypoalgesia. Previous studies show that this hypoalgesia is blocked by the intrathecal injection of either phentolamine or methysergide. The present study demonstrates that depletion of spina...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(83)90113-6
更新日期：1983-07-01 00:00:00
abstract：:A survey of the psychological characteristics of a large sample of chronic headache cases (n = 360), including classical and common migraine and tension headache sufferers, was carried out. Comparing groups defined in terms of the chronicity of their headache problems, it was found that those with a longer history of ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(85)90286-6
更新日期：1985-02-01 00:00:00
abstract：:The effect of PF-04457845, a potent and selective fatty acid amide hydrolase-1 (FAAH1) inhibitor, on pain due to osteoarthritis of the knee was investigated in a randomised placebo and active-controlled clinical trial. The trial involved 2 periods (separated by a 2-week washout) consisting of a 1-week wash-in phase fo...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2012.04.020
更新日期：2012-09-01 00:00:00
abstract：:Snakebites are a relevant public health problem in Central and South America. Snake bite envenomations cause intense pain, not relieved by anti-venom. The fangs of many species are short, causing subcutaneous injection. Fangs of larger species inflict subcutaneous or intramuscular envenomation. To understand pain indu...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.06.001
更新日期：2004-09-01 00:00:00
abstract：:A mounting body of literature recommends that treatment for fibromyalgia (FM) encompass medications, exercise and improvement of coping skills. However, there is a significant gap in determining an effective counterpart to pharmacotherapy that incorporates both exercise and coping. The aim of this randomized controlle...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2010.08.020
更新日期：2010-11-01 00:00:00
abstract：:Treatment of neuropathic pain is a major clinical challenge that has been met with minimal success. After peripheral nerve injury, a decrease in the expression of the K-Cl cotransporter KCC2, a major neuronal Cl(-) extruder, leads to pathologic alterations in GABA(A) and glycine receptor function in the spinal cord. T...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.11.015
更新日期：2010-02-01 00:00:00
abstract：:This study determined preoperative predictors of movement and resting pain following total knee replacement (TKR). We hypothesized that younger patients with higher preoperative pain intensity, pain sensitivity, trait anxiety, pain catastrophizing, and depression would be more likely to experience higher postoperative...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.06.021
更新日期：2012-11-01 00:00:00
abstract：:Fifty-seven patients (74%) who had completed a multidisciplinary pain program returned mailed questionnaires assessing both outcome and compliance measures. Significant treatment gains were observed at follow-up. Compliance with prescribed therapeutic regimens was low, averaging around 42% for individual regimens. Com...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(83)90102-1
更新日期：1983-11-01 00:00:00
abstract：:Chronic complications of traumatic brain injury represent one of the greatest financial burdens and sources of suffering in the society today. A substantial number of these patients suffer from posttraumatic headache (PTH), which is typically associated with tactile allodynia. Unfortunately, this phenomenon has been u...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000002103
更新日期：2020-10-02 00:00:00
abstract：:Tramadol hydrochloride is a synthetic mu-opioid agonist with additional monoaminergic activity. Tramadol's analgesic effect has been equated with that of pethidine, with a more favourable side-effect profile. Tramadol has been the most-selling prescription analgesic in Germany for several years, and it is now availabl...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(95)00056-X
更新日期：1995-07-01 00:00:00
abstract：:Since many people with chronic fatigue present with pain and many people with chronic pain present with fatigue, we tested if fatigue would enhance the response to pain in male and female mice. We further tested for the activation of brainstem nuclei by the fatigue task using c-fos as a marker. Fatigue was induced by ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.07.001
更新日期：2010-02-01 00:00:00
abstract：:We studied whether striatal alpha(2)-adrenoceptors or N-methyl-d-aspartate (NMDA) receptors influence descending regulation of neuropathic hypersensitivity in the rat by microinjecting an alpha(2)-adrenoceptor agonist or NMDA-receptor antagonist into the dorsal striatum in animals with a spinal nerve ligation-induced ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.08.009
更新日期：2008-07-01 00:00:00
abstract：:The proinflammatory cytokine interferon-gamma (IFN-gamma), which can be present in elevated levels in the central nervous system during pathological conditions, may be involved in the generation of persistent pain states by inducing neuronal hyperexcitability. The aim of the present study was to examine whether loss o...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.02.010
更新日期：2007-12-15 00:00:00
abstract：:In primary care and physical therapy settings, we evaluated an intervention for chronic back pain patients which incorporated fear reducing and activating techniques. Primary care patients seen for back pain in primary care were screened to identify persons with significant activity limitations 8-10 weeks after their ...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.pain.2004.11.007
更新日期：2005-02-01 00:00:00
abstract：:Plastic changes in the anterior cingulate cortex (ACC) are critical in pain hypersensitivity caused by peripheral nerves injury. The Notch signaling pathway has been shown to regulate synaptic differentiation and transmission. Therefore, this study was to investigate the function of the Notch signaling pathway in the ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000002014
更新日期：2021-01-01 00:00:00
abstract：:Transient receptor potential ion channel melastatin subtype 8 (TRPM8) is activated by cold temperatures and cooling agents, such as menthol and icilin. Compounds containing peppermint are reported to reduce symptoms of bowel hypersensitivity; however, the underlying mechanisms of action are unclear. Here we determined...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.01.027
更新日期：2011-07-01 00:00:00
abstract：:Antinociceptive effects of the 2 (each 1000 mg, orally) non-steroidal anti-inflammatory drugs (NSAIDs) acetaminophen (paracetamol) and antipyrine (phenazone) were investigated with a non-inflammatory experimental pain model in 32 healthy volunteers. Phasic pain was induced by intracutaneously applied brief electrical ...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(92)90165-8
更新日期：1992-08-01 00:00:00
abstract：:Numerous behavioral pain measures have been validated for young children, but none is appropriate to assess pain in emergency departments (EDs), where caregivers need a simple, easily completed scale. Our objective was to elaborate and validate a tool, relevant in any painful situation, with agitation or prostration, ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.02.024
更新日期：2012-08-01 00:00:00
abstract：:The responses of preterm neonates to acute tissue-damaging stimuli have been described. However, factors which influence these responses have received little attention. In this study, we observed 124 premature infants before, during and after a routine heel lance and determined how two contextual variables (severity o...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(94)90053-1
更新日期：1994-10-01 00:00:00
