Adhesion molecules involved in protein kinase A- and C-dependent lymphocyte adherence to microvascular endothelial cells.

Abstract:

:A twofold increase in lymphocyte adherence to rat microvascular endothelial cells (EC) was achieved by incubating EC for 4 h with IL-1 alpha or dibutyryl-cAMP (stimulators of protein kinase A, PKA) and PMA (stimulator of protein kinase C, PKC). Monoclonal antibodies anti-CD11a, anti-CD18 (LFA-1) and anti-CD49d (VLA-4 alpha) significantly inhibited the increased lymphocyte binding to IL-1 alpha-induced EC, anti-CD18 and to a lesser extent anti-CD11a and anti-CD49d to dibutyryl-cAMP-induced EC, whereas only anti-CD11a and anti-CD18 monoclonal antibodies inhibited PMA-induced lymphocyte binding. These findings suggest that stimulation of PKA and PKC induces lymphocyte binding to EC via different adhesion molecules.

journal_name

Scand J Immunol

authors

Turunen JP,Ustinov J,Renkonen R

doi

10.1111/j.1365-3083.1993.tb02555.x

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

282-8

issue

3

eissn

0300-9475

issn

1365-3083

journal_volume

37

pub_type

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