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Association Between TNF-α Promoter -308 A/G Polymorphism and Systemic Lupus Erythematosus Susceptibility: A Case-Control Study and Meta-Analysis.

Abstract：

:The tumour necrosis factor-α (TNF-α) promoter -308 A/G polymorphism plays an important role in the aetiology of systemic lupus erythematosus (SLE). Several studies have estimated the association between TNF-α -308 A/G and SLE risk. However, results were inconsistent. A case-control study was carried out to explore the association between TNF-α -308 A/G and the SLE risk in a Chinese Han population. Meta-analysis combining present with previous studies was conducted to further explore the association. Our case-control study included 556 patients with SLE along with 570 matched healthy controls. TNF-α -308 A allele was significantly increased in patients with SLE compared with controls (OR = 2.184, 95% CI: 1.718-2.778, P < 0.001). Genotypes AA and AG were associated with the susceptibility to SLE as compared with the GG genotype, as well as the dominant model (AA+AG versus GG), respectively. The meta-analysis included 41 comparative studies involving 4799 patients and 6635 controls. An association between SLE and allele A was found in the overall populations (OR = 1.70, 95% CI: 1.46-1.98, P < 0.001). In addition, we discussed the correlation between this polymorphism and lupus nephritis (LN) risk, showing that allele A was significantly related to LN in the overall populations (OR = 1.80, 95% CI: 1.21-2.68, P = 0.004). The results from our case-control study and the meta-analysis indicate that the TNF-α -308 A allele is significantly associated with an increased risk of SLE/LN.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Yang ZC,Xu F,Tang M,Xiong X

doi

10.1111/sji.12516

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

197-210

issue

3

eissn

0300-9475

issn

1365-3083

journal_volume

85

pub_type

杂志文章,meta分析

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