Primary structure of the wall peptidoglycan of leprosy-derived corynebacteria.

Abstract:

:The cell walls isolated from axenically grown leprosy-derived corynebacteria were submitted to various chemical and enzymatic degradations. The glycan strands of the wall peptidoglycan are essentially composed of N-acetylglycosaminyl-N-acetylmuramic acid disaccharide units. Small amounts of N-acetylglycosaminyl-N-glycolylmuramic acid (less than 10%) were also detected. The muramic acid residues of adjacent glycan strands are substituted by amidated tetrapeptide units which, in turn, are cross-linked through direct linkages extending between the C-terminal D-alanine residue of one tetrapeptide and the mesodiaminopimelic acid residue of another tetrapeptide. Such a structure is very similar to that of the wall peptidoglycan found in the taxonomically related microorganisms of the Corynebacterium, Mycobacterium, and Nocardia groups.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Janczura E,Leyh-Bouille M,Cocito C,Ghuysen JM

doi

10.1128/JB.145.2.775-779.1981

subject

Has Abstract

pub_date

1981-02-01 00:00:00

pages

775-9

issue

2

eissn

0021-9193

issn

1098-5530

journal_volume

145

pub_type

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