The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment.

Abstract:

:The Saccharomyces cerevisiae gene MEC1 represents a structural homolog of the human gene ATM mutated in ataxia telangiectasia patients. Like human ataxia telangiectasia cell lines, mec1 mutants are defective in G2 and S-phase cell cycle checkpoints in response to radiation treatment. Here we show an additional defect in G1 arrest following treatment with UV light or gamma rays and map a defective arrest stage at or upstream of START in the yeast cell cycle.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Siede W,Allen JB,Elledge SJ,Friedberg EC

doi

10.1128/jb.178.19.5841-5843.1996

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

5841-3

issue

19

eissn

0021-9193

issn

1098-5530

journal_volume

178

pub_type

杂志文章
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