Experimental model of Klebsiella infection in mice for studies on mechanisms of local immunity of the respiratory tract.

Abstract:

:An experimental model in white mice, infected with a mildly virulent strain of Klebsiella pneumoniae, was elaborated for studies on local immunity of the respiratory tract. Instillation of klebsiella into the supralaryngeal space of anaesthetised animals proved to be more suitable than the commonly used method of intranasal infection. The strain administered by the supralaryngeal route, persisted in the lungs of most mice at approximately equal level 1 d after infection, in some animals it could be demonstrated even after 2-3 d. Using this model (based on various rates of lung clearance), one can demonstrate faster elimination of klebsiella after a local (supralaryngeal) than systemic (intraperitoneal) immunization with a heat-inactivated vaccine, prepared from a homologous strain of K. pneumoniae.

journal_title

Folia microbiologica

authors

Libich J,Franĕk J,Hásková V

doi

10.1007/BF02879494

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

424-9

issue

5

eissn

0015-5632

issn

1874-9356

journal_volume

28

pub_type

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