Sterol composition of nystatin-resistant Candida maltosa mutants.

Abstract:

:Composition of sterol fractions of nystatin-resistant Candida maltosa strains was determined. Using UV-spectrometry, TLC and GLC-MS it was demonstrated that resistance to nystatin is connected with the composition alterations of yeast cell sterols. Block of different stages of ergosterol biosynthesis was revealed in some mutants, viz. C-24-transmethylation, delta 8----delta 7-isomerization, 14 alpha-demethylation, C-5(6)-dehydrogenation, reduction of C-14(15) and C-24(28) double bonds.

journal_title

Folia microbiologica

authors

Mikhailova NP,Sorokoletova EF,Durasova EN,Vyunov KA,Shapovalov OI

doi

10.1007/BF02814494

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

148-52

issue

2

eissn

0015-5632

issn

1874-9356

journal_volume

36

pub_type

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