Histidine-mediated control of tryptophan biosynthetic enzymes in Neurospora crassa.

Abstract:

:The formation of the five tryptophan biosynthetic enzymes of Neurospora crassa was shown to be derepressed in histidine-starved cells. This histidine-mediated derepression was not due to a lowered intracellular concentration of tryptophan in these cells. Furthermore, histidine-mediated derepression of tryptophan enzymes was found to be coordinate and not subject to reversal by tryptophan of either exogenous or biosynthetic origin. The synthesis of tryptophan enzymes also was found to be coordinate in cells which were not histidine-starved. Although histidine is clearly involved in regulating the synthesis of tryptophan enzymes, it did not prevent either tryptophan-mediated derepression of tryptophan enzymes or indole-3-glycerol phosphate-mediated derepression of tryptophan synthetase.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Carsiotis M,Jones RF,Lacy AM,Cleary TJ,Fankhauser DB

doi

10.1128/JB.104.1.98-106.1970

subject

Has Abstract

pub_date

1970-10-01 00:00:00

pages

98-106

issue

1

eissn

0021-9193

issn

1098-5530

journal_volume

104

pub_type

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