Differential depression of staphylococcal plasmid and chromosomal penicillinase genes by a class of unlinked chromosomal mutations (R2-).

Abstract:

:We described previously a class of mutations (phenotypic designation R2(-)) in Staphylococcus aureus that were unlinked to penicillinase genes but nevertheless imposed constitutive synthesis of this enzyme upon wild-type plasmids. The plasmids affected by these mutations have been found to possess the same maintenance-compatibility type (I) and to form penicillinase of serotype A. Three plasmids that had a different maintenance-compatibility type (II) and formed penicillinase of serotype C were only slightly derepressed in R2(-) mutants. Three chromosomal penicillinase genes were variably derepressed, the range extending from negligible to nearly complete derepression. The differences in degree of derepression among the three types of penicillinase linkage groups were tentatively ascribed to position effects.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Cohen S,Vernon EG,Sweeney HM

doi

10.1128/JB.103.3.616-621.1970

subject

Has Abstract

pub_date

1970-09-01 00:00:00

pages

616-21

issue

3

eissn

0021-9193

issn

1098-5530

journal_volume

103

pub_type

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