Role of the C terminus of FtsK in Escherichia coli chromosome segregation.

Abstract:

:FtsK is essential for Escherichia coli cell division. We report that cells lacking the C terminus of FtsK are defective in chromosome segregation as well as septation, often exhibiting asymmetrically positioned nucleoids and large anucleate regions. Combining the corresponding truncated ftsK gene with a mukB null mutation resulted in a synthetic lethal phenotype. When the truncated ftsK was combined with a minCDE deletion, chains of minicells were generated, many of which contained DNA. These results suggest that the C terminus of FtsK has an important role in chromosome partitioning.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Yu XC,Weihe EK,Margolin W

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

6424-8

issue

23

eissn

0021-9193

issn

1098-5530

journal_volume

180

pub_type

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