Nucleotide sequence of the Salmonella typhimurium mutB gene, the homolog of Escherichia coli mutY.

Abstract:

:The mutB gene of Salmonella typhimurium is involved in a methylation-independent repair pathway specific for A/G or A/C mismatches and is the homolog of the Escherichia coli mutY gene. The mutB gene of S. typhimurium was cloned and sequenced. The isolated mutB clone reduced the mutation rate of the mutB mutant to wild-type levels and also restored A/G mismatch-specific nicking activity, which is defective in mutB extracts. The amino acid sequence encoded by the mutB gene is 91% homologous to that encoded by the E. coli mutY gene.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Desiraju V,Shanabruch WG,Lu AL

doi

10.1128/jb.175.2.541-543.1993

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

541-3

issue

2

eissn

0021-9193

issn

1098-5530

journal_volume

175

pub_type

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