Abstract：
:Calcitonin gene-related peptide-immunoreactive cells were identified within the epithelium of distal conducting airways in the human fetus and infant. Several peptides and amines, including calcitonin, have been identified previously within a specific population of airway epithelial cells. These cells, referred to as pulmonary neuroendocrine cells, are postulated to be airway chemoreceptors responsible for changes in ventilation and perfusion in response to changes in airway gas composition. Calcitonin gene-related peptide immunoreactive cells could be identified throughout the period of development studies (20 weeks gestation to 3 months of age), but were present in only limited numbers in less than 50% of individuals (n = 23). In contrast, large numbers of calcitonin gene-related peptide immunoreactive cells were identified in 100% of infants (1-3 months, n = 5) with bronchopulmonary dysplasia. The differential processing of mRNA transcribed from the calcitonin gene in neural and non-neural tissue suggests that calcitonin, rather than calcitonin gene-related peptide, is the primary product of translation in pulmonary neuroendocrine cells. However, considering the potent vasodilatory and bronchoconstrictive effects of calcitonin gene-related peptide, its presence in pulmonary neuroendocrine cells, even in small amounts, may be important in controlling pulmonary vaso- and/or bronchomotor tone. The presence of large numbers of calcitonin gene-related peptide immunoreactive cells in infants with bronchopulmonary dysplasia suggests that calcitonin gene-related peptide may be one further agent contributing to the pulmonary pathophysiology seen in this disease.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Johnson DE,Wobken JDdoi
10.1007/BF00218949subject
Has Abstractpub_date
1987-12-01 00:00:00pages
579-83issue
3eissn
0302-766Xissn
1432-0878journal_volume
250pub_type
杂志文章abstract：:Digital dermatitis (DD), a common ulcerative disease of the bovine foot causing lameness and reducing productivity and animal welfare, is associated with infection by spirochete Treponema bacteria. Topical tetracycline, the most common treatment, has inconsistent cure rates; therefore, new therapeutic options are need...
journal_title：Cell and tissue research
pub_type： 杂志文章
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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更新日期：1978-11-20 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
pub_type： 杂志文章
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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更新日期：1983-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00319368
更新日期：1992-03-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1979-06-27 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1996-02-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1993-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00441-005-0135-7
更新日期：2006-06-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1989-02-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1976-06-28 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1975-11-19 00:00:00
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pub_type： 杂志文章
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1991-09-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1979-08-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-020-03176-y
更新日期：2020-07-01 00:00:00
abstract：:Neurons are extremely polarised cells in which the cytoskeleton, composed of microtubules, microfilaments and neurofilaments, plays a crucial role in maintaining structure and function. Neurofilaments, the 10-nm intermediate filaments of neurons, provide structure and mechanoresistance but also provide a scaffolding f...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
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更新日期：2015-06-01 00:00:00
abstract：:The otoconia of Amphibia, especially of the frog Rana esculenta, were studied by X-ray diffraction and scanning electron microscopy (SEM). The SEM studies showed that the membranous labyrinth of Amphibia contains two populations of crystals, which can easily be distinguished by their forms. The X-ray diffraction data ...
journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
