Abstract：
:The suprachiasmatic nucleus (SCN) contains a biological clock that generates timing signals that drive daily rhythms in behaviors and homeostatic functions. In addition to this pacemaker function, the SCN gates its own sensitivity to incoming signals, which permits appropriate temporal adjustment to achieve synchrony with environmental and organismic states. A series of time-domains, in which the SCN restricts its own sensitivity to a limited set of stimuli that adjust clock phase, can be distinguished. Pituitary adenylyl cyclase-activating peptide (PACAP) and cAMP directly reset clock phase during the daytime domain; both cause phase advances only during the clock's day-time domain, but are without effect at night. In contrast, acetylcholine and cGMP analogs phase advance the clock only when applied during the night. Sensitivity to light and glutamate arises concomitant with sensitivity to acetylcholine and cGMP. Light and glutamate cause phase delays in the early night, by elevating intracellular Ca(2+) via neuronal ryanodine receptors. In late night, light and glutamate utilize a cGMP-mediated mechanism to induce phase advances. Nocturnal responses of SCN primed by light or glutamate can be modulated by effectors of phase-resetting in daytime, namely, PACAP and cAMP. Finally, the dusk and dawn domains are characterized by sensitivity to the pineal hormone, melatonin, acting through protein kinase C. These changing patterns of sensitivities demonstrate that the circadian clock controls multiple intracellular gates, which ensures that they can be opened selectively only at specific points in the circadian cycle. Discerning the molecular bases of these changes is fundamental to understanding integrative and regulatory mechanisms in the circadian system.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Gillette MU,Mitchell JWdoi
10.1007/s00441-002-0576-1keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
99-107issue
1eissn
0302-766Xissn
1432-0878journal_volume
309pub_type
杂志文章,评审abstract：:Ornithine decarboxylase (ODC) activity was measured in homogenates of neonatal rabbit ovaries from the day of birth to day 22, an interval that corresponds to the progressing stages of the meiotic prophase from oogonia to diplotene and follicle formation. The ODC-activity was high on days 1 and 3 when most germ cells ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218114
更新日期：1983-01-01 00:00:00
abstract：:Two types of mitochondria-rich cells were found in the interplatelet areas of the gills of the migrating river lamprey. Both cell types are thought to be responsible for ion-transport across the gills. In the fresh-run migrant the gills are dominated by large, flask-shaped cells which show some ultrastructural similar...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221380
更新日期：1976-10-06 00:00:00
abstract：:The meninges of albino Wistar rat embryos, aged between the 11th embryonic day (ED) and birth, were sectioned using a specially constructed device. This technique permits optimal microanatomical preservation of all tissues covering the convexity of the brain: skin, muscle, cartilage or bone, and the meninges. At ED11,...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221652
更新日期：1989-07-01 00:00:00
abstract：:Thy-1, a glycophosphatidylinositol-linked glycoprotein of the outer membrane leaflet, has been described in myofibroblasts of several organs. Previous studies have shown that, in fetal liver, Thy-1 is expressed in a subpopulation of ductular/progenitor cells. The aim of this study has been to investigate whether the l...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0437-z
更新日期：2007-09-01 00:00:00
abstract：:Transforming growth factor-β (TGFβ) is the prototype for a large family of pleiotropic factors that signal via heterotetrameric complexes of type I and type II serine/threonine kinase receptors. Important intracellular mediators of TGFβ signaling are members of the Smad family. Smad2 and 3 are activated by C-terminal ...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-011-1190-x
更新日期：2012-01-01 00:00:00
abstract：:Electron microscopy of the rat lymph node disclosed reticular cells in close association with bundles of collagenous fibrils 30-45 nm in diameter, and electron lucent "amorphous" substances surrounded by microfibrils 11 nm in diameter, with junctional complexes. The amorphous substances, distinctly revealed by orcein ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210522
更新日期：1981-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-004-0967-6
更新日期：2004-11-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050562
更新日期：1996-04-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00232837
更新日期：1976-11-18 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-012-1339-2
更新日期：2012-03-01 00:00:00
abstract：:Olfactory marker protein (OMP) was first described as a protein expressed in olfactory receptor neurons (ORNs) in the nasal cavity. In particular, OMP, a small cytoplasmic protein, marks mature ORNs and is also expressed in the neurons of other nasal chemosensory systems: the vomeronasal organ, the septal organ of Mas...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-020-03349-9
更新日期：2021-01-15 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004419900107
更新日期：1999-12-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00222119
更新日期：1975-08-01 00:00:00
abstract：:Antisera to the neuropeptides corazonin (Crz) and crustacean cardioactive peptide (CCAP) and to the diapause hormone (DH) react with small sets of neurones in the cephalic ganglia of the crickets Dianemobius nigrofasciatus and Allonemobius allardi. The distribution of their immunoreactivities is similar in the two spe...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-006-0339-5
更新日期：2007-04-01 00:00:00
abstract：:The published online version contains mistake in Title and in Acknowledgement section. Please find below for the needed corrections. ...
journal_title：Cell and tissue research
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00441-018-2865-3
更新日期：2018-10-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00227029
更新日期：1977-05-10 00:00:00
abstract：:The larval stage of Polypodium hydriforme is planuliform and parasitic inside the growing oocytes of acipenserid fishes. The larva has inverted germ layers and a special envelope, the trophamnion, surrounding it within the host oocyte. The trophamnion is a giant unicellular provisory structure derived from the second ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237977
更新日期：1980-01-01 00:00:00
abstract：:The presence and distribution in the peri-insular region of extracellular matrix, and in particular basement membrane, was investigated in a comparative study comprising pancreata of rat, dog, pig, and man. Basement membrane markers, collagen type-IV and laminin, were determined immunohistochemically. Additional infor...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318700
更新日期：1992-01-01 00:00:00
abstract：:Synapses in the lateral septum of the murine brain have been investigated by ultrastructural immunocytochemistry, using monoclonal anti-neurophysins in both immunoperoxidase and immunogold techniques. In the region shown by light microscopy to be rich in vasopressinergic innervation, synaptic boutons containing approx...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215524
更新日期：1987-08-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00223015
更新日期：1975-12-10 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410051204
更新日期：1998-12-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00231019
更新日期：1978-08-25 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-009-0912-9
更新日期：2010-03-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1618-6
更新日期：2013-06-01 00:00:00
abstract：:The development of the egg envelope and its incorporation into the larval cuticle of the polychaete Phragmatopoma lapidosa, was studied by correlative scanning and transmission electron microscopy. The mature egg possesses an envelope composed of five zones including an outer granular zone formed by the tips of the eg...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00225530
更新日期：1978-01-17 00:00:00
abstract：:Caveolae or membrane vesicles are commonly observed in smooth and skeletal muscle as well as in working heart muscle. Using sections of fixed tissue and replicas of freeze-cleaved material, we show in this study that caveolae are also very numerous in sinus node cells of the rabbit, and to a lesser degree, in the atri...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00234869
更新日期：1980-01-01 00:00:00
abstract：:The comparatively simple Caenorhabditis elegans intestine fulfills many of the complex functions of the mammalian digestive tract, liver, and fat tissues, while also having roles in pathogen defense, immunity, and longevity. In this review, we describe the structure of the C. elegans gut and how it develops from the e...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-019-03036-4
更新日期：2019-09-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050887
更新日期：1997-09-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215308
更新日期：1976-05-13 00:00:00
abstract：:To identify and describe ovarian follicles committed to undergo follicular degeneration (atresia), immature rats were primed with pregnant mare serum gonadotropin (PMSG). After PMSG treatment, preovulatory follicles develop but subsequently degenerate. Prior to the appearance of pyknotic nuclei (Stage I of atresia), d...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00233727
更新日期：1980-01-01 00:00:00
