The ultrastructure of guinea pig heterophil granulocytes and the heterogeneity of the granules.

Abstract:

:The development of the heterophil granulocytes in the bone marrow of the guinea pig is described. During the maturation of these cells, three types of granule are formed, not only the azurophil and specific granules already described in other mammals but also a third type of granule referred to here as the nucleated granule. During the process of maturation of the cells, these three types of granule are formed successively. On this basis, two steps can be distinguished in the promyelocyte phase in which primary (nucleated and azurophil) granules are formed, i.e. an early and late stage, nucleated granules being formed in early and azurophil granules in late promyelocytes. Secondary (specific) granules occur first in myelocytes. In mature heterophils of the guinea pig the granule population is composed of about 85% secondary granules, about 10% azurophil granules, and about 5% nucleated granules. The changes in the granule population during the maturation process were quantified. The observations and calculations point to the occurrence of three mitoses: one in the early and one in the late promyelocyte and the third in the myelocyte.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Brederoo P,Daems WT

doi

10.1007/BF00220388

subject

Has Abstract

pub_date

1978-11-20 00:00:00

pages

183-205

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

194

pub_type

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