Abstract:
:DNA damaging agents have been a cornerstone of cancer therapy for nearly a century. The discovery of many of these chemicals, particularly the alkylating agents, are deeply entwined with the development of poisonous materials originally intended for use in warfare. Over the last decades, their anti-proliferative effects have focused on the specific mechanisms by which they damage DNA, and the factors involved in the repair of such damage. Due to the variety of aberrant adducts created even for the simplest alkylating agents, numerous pathways of repair are engaged as a defense against this damage. More recent work has underscored the role of RNA damage in the cellular response to these agents, although the understanding of their role in relation to established DNA repair pathways is still in its infancy. In this review, we discuss the chemistry of alkylating agents, the numerous ways in which they damage nucleic acids, as well as the specific DNA and RNA repair pathways which are engaged to counter their effects.
journal_name
Crit Rev Biochem Mol Bioljournal_title
Critical reviews in biochemistry and molecular biologyauthors
Tsao N,Schärer OD,Mosammaparast Ndoi
10.1080/10409238.2020.1869173subject
Has Abstractpub_date
2021-01-12 00:00:00pages
1-31eissn
1040-9238issn
1549-7798pub_type
杂志文章abstract::Clathrin constitutes the coat of vesicles involved in three receptor-mediated intracellular transport pathways; the export of aggregated material from the trans-Golgi network for regulated secretion, the transfer of lysosomal hydrolases from the trans-Golgi network to lysosomes and receptor-mediated endocytosis at the...
journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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abstract::Ribonucleases (RNases) are mediators in most reactions of RNA metabolism. In recent years, there has been a surge of new information about RNases and the roles they play in cell physiology. In this review, a detailed description of bacterial RNases is presented, focusing primarily on those from Escherichia coli and Ba...
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journal_title:Critical reviews in biochemistry and molecular biology
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abstract::Insulin-degrading enzyme (IDE) is a ubiquitous zinc peptidase of the inverzincin family, which has been initially discovered as the enzyme responsible for insulin catabolism; therefore, its involvement in the onset of diabetes has been largely investigated. However, further studies on IDE unraveled its ability to degr...
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