Abstract:
:The maintenance of genomic stability relies on the coordinated action of a number of cellular processes, including activation of the DNA-damage checkpoint, DNA replication, DNA repair, and telomere homeostasis. Many proteins involved in these cellular processes use different types of functional modules to regulate and execute their functions. Recent studies have revealed that many DNA-damage checkpoint and DNA repair proteins in human cells possess the oligonucleotide/oligosaccharide-binding (OB) fold domains, which are known to bind single-stranded DNA in both prokaryotes and eukaryotes. Furthermore, during the DNA damage response, the OB folds of the human checkpoint and DNA repair proteins play critical roles in DNA binding, protein complex assembly, and regulating protein-protein interactions. These findings suggest that the OB fold is an evolutionarily conserved functional module that is widely used by genome guardians. In this review, we will highlight the functions of several well-characterized or newly discovered eukaryotic OB-fold proteins in the DNA damage response.
journal_name
Crit Rev Biochem Mol Bioljournal_title
Critical reviews in biochemistry and molecular biologyauthors
Flynn RL,Zou Ldoi
10.3109/10409238.2010.488216subject
Has Abstractpub_date
2010-08-01 00:00:00pages
266-75issue
4eissn
1040-9238issn
1549-7798journal_volume
45pub_type
杂志文章,评审abstract::The lytic transglycosylases (LTs) are bacterial enzymes that catalyze the non-hydrolytic cleavage of the peptidoglycan structures of the bacterial cell wall. They are not catalysts of glycan synthesis as might be surmised from their name. Notwithstanding the seemingly mundane reaction catalyzed by the LTs, their lytic...
journal_title:Critical reviews in biochemistry and molecular biology
pub_type: 杂志文章,评审
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abstract::Telomere DNA-binding proteins protect the ends of chromosomes in eukaryotes. A subset of these proteins are constructed with one or more OB folds and bind with G+T-rich single-stranded DNA found at the extreme termini. The resulting DNA-OB protein complex interacts with other telomere components to coordinate critical...
journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
pub_type: 杂志文章,评审
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
pub_type: 杂志文章,评审
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journal_title:Critical reviews in biochemistry and molecular biology
pub_type: 杂志文章,评审
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journal_title:Critical reviews in biochemistry and molecular biology
pub_type: 杂志文章,评审
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abstract::Rapid advances in redox systems biology are creating new opportunities to understand complexities of human disease and contributions of environmental exposures. New understanding of thiol-disulfide systems have occurred during the past decade as a consequence of the discoveries that thiol and disulfide systems are mai...
journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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abstract::DNA damaging agents have been a cornerstone of cancer therapy for nearly a century. The discovery of many of these chemicals, particularly the alkylating agents, are deeply entwined with the development of poisonous materials originally intended for use in warfare. Over the last decades, their anti-proliferative effec...
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journal_title:Critical reviews in biochemistry and molecular biology
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abstract::The unfolded protein response (UPR) is induced when the quality control machinery of the cell is overloaded with unfolded proteins or when one of the functions of the endoplasmic reticulum (ER) is perturbed. Here, I describe UPR in yeast and mammals, and compare it to what we know about pathogenic fungi and the parasi...
journal_title:Critical reviews in biochemistry and molecular biology
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abstract::This review focuses on how microbes live on CO as a sole source of carbon and energy and with CO by generating carbon monoxide as a metabolic intermediate. The use of CO is a property of organisms that use the Wood-L jungdahl pathway of autotrophic growth. The review discusses when CO metabolism originated, when and h...
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