Comparative modeling of proteins in the design of novel renin inhibitors.

abstract：:The major intrinsic protein (MIP) of the bovine lens fiber cell membrane was the first member of the MIP family of proteins to be sequenced and characterized. It is probably a homotetramer with transmembrane channel activity that plays a role in lens biogenesis or maintenance. The polypeptide chain of each subunit may...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Reizer J,Reizer A,Saier MH Jr

更新日期：1993-01-01 00:00:00

abstract：:The eukaryotic MCM2-7 complex is recruited onto origins of replication during the G1 phase of the cell cycle and acts as the main helicase at the replication fork during the S phase. Over the last few years a number of structural reports on MCM proteins using both electron microscopy and protein crystallography have b...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Costa A,Onesti S

更新日期：2009-09-01 00:00:00

abstract：:Receptor for advanced glycation end products (RAGE) is an immunoglobulin-like receptor present on cell surface. RAGE binds to an array of structurally diverse ligands, acts as a pattern recognition receptor (PRR) and is expressed on cells of different origin performing different functions. RAGE ligation leads to the i...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Jangde N,Ray R,Rai V

更新日期：2020-12-01 00:00:00

abstract：:Glycosaminoglycans (GAGs) play an intricate role in the extracellular matrix (ECM), not only as soluble components and polyelectrolytes, but also by specific interactions with growth factors and other transient components of the ECM. Modifications of GAG chains, such as isomerization, sulfation, and acetylation, gener...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Ernst S,Langer R,Cooney CL,Sasisekharan R

更新日期：1995-01-01 00:00:00

abstract：:S-Acylation (commonly referred to as S-palmitoylation) is a post-translational modification consisting in the covalent attachment of an acyl chain to a cysteine residue of the target protein. The lability of the resulting thioester bond gives S-acylation an essential characteristic: its reversibility. S-acylation dyna...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Zaballa ME,van der Goot FG

更新日期：2018-08-01 00:00:00

abstract：:HEPN (Higher Eukaryotes and Prokaryotes Nucleotide-binding) RNases are an emerging class of functionally diverse RNA processing and degradation enzymes. Members are defined by a small α-helical bundle encompassing a short consensus RNase motif. HEPN dimerization is a universal requirement for RNase activation as the c...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Pillon MC,Gordon J,Frazier MN,Stanley RE

更新日期：2021-02-01 00:00:00

abstract：:Translational control mechanisms are, besides transcriptional control and mRNA stability, the most determining for final protein levels. A large number of accessory factors that assist the ribosome during initiation, elongation, and termination of translation are required for protein synthesis. Cap-dependent translati...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Van Der Kelen K,Beyaert R,Inzé D,De Veylder L

更新日期：2009-07-01 00:00:00

abstract：:As we learn more about the biology of the Toll-like receptors (TLRs), a wide range of molecules that can activate this fascinating family of pattern recognition receptors emerges. In addition to conserved pathogenic components, endogenous danger signals created upon tissue damage are also sensed by TLRs. Detection of ...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Bryant CE,Gay NJ,Heymans S,Sacre S,Schaefer L,Midwood KS

更新日期：2015-01-01 00:00:00

abstract：:Low-copy nuclear genes in plants are a rich source of phylogenetic information. They hold a great potential to improve the robustness of phylogenetic reconstruction at all taxonomic levels, especially where universal markers such as cpDNA and nrDNA are unable to generate strong phylogenetic hypotheses. Low-copy nuclea...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Sang T

更新日期：2002-01-01 00:00:00

abstract：:Proper and timely regulation of cellular processes is fundamental to the overall health and viability of organisms across all kingdoms of life. Thus, organisms have evolved multiple highly dynamic and complex biochemical signaling cascades in order to adapt and survive diverse challenges. One such method of conferring...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Crawford K,Bonfiglio JJ,Mikoč A,Matic I,Ahel I

更新日期：2018-02-01 00:00:00

abstract：:Regulation of eukaryotic gene expression is far more complex than one might have imagined 30 years ago. However, progress towards understanding gene regulatory mechanisms has been rapid and comprehensive, which has made the integration of detailed observations into broadly connected concepts a challenge. This review a...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Venters BJ,Pugh BF

更新日期：2009-06-01 00:00:00

abstract：:The discovery that SRA RNA can function as a nuclear receptor (NR) coactivator resulted in a fundamental change in the perception of how NRs and their coregulators may regulate hormone signaling pathways. The subsequent identification of molecules capable of binding SRA, including SHARP, p68, and more recently SLIRP, ...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Colley SM,Leedman PJ

更新日期：2009-01-01 00:00:00

abstract：:DNA double-strand breaks are highly toxic DNA lesions that cause genomic instability, if not efficiently repaired. RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in several DNA repair pathways, including DNA double-strand break repair. Double-stra...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Keijzers G,Maynard S,Shamanna RA,Rasmussen LJ,Croteau DL,Bohr VA

更新日期：2014-11-01 00:00:00

abstract：:The demonstration that ribosomal peptide synthesis is a ribozyme-catalyzed reaction makes it almost certain that there was once an RNA World. The central problem for origin-of-life studies, therefore, is to understand how a protein-free RNA World became established on the primitive Earth. We first review the literatur...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Orgel LE

更新日期：2004-03-01 00:00:00

abstract：:The unfolded protein response (UPR) is induced when the quality control machinery of the cell is overloaded with unfolded proteins or when one of the functions of the endoplasmic reticulum (ER) is perturbed. Here, I describe UPR in yeast and mammals, and compare it to what we know about pathogenic fungi and the parasi...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Michaeli S

更新日期：2015-01-01 00:00:00

abstract：:The reorganization of metabolic pathways in cancer facilitates the flux of carbon and reducing equivalents into anabolic pathways at the expense of oxidative phosphorylation. This provides rapidly dividing cells with the necessary precursors for membrane, protein and nucleic acid synthesis. A fundamental metabolic per...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Ridgway ND

更新日期：2013-01-01 00:00:00

abstract：:Aldehydes are highly reactive molecules that may have a variety of effects on biological systems. They can be generated from a virtually limitless number of endogenous and exogenous sources. Although some aldehyde-mediated effects such as vision are beneficial, many effects are deleterious, including cytotoxicity, mut...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Lindahl R

更新日期：1992-01-01 00:00:00

abstract：:RNA helicases represent a large family of proteins that have been detected in almost all biological systems where RNA plays a central role. They are ubiquitously distributed over a wide range of organisms and are involved in nuclear and mitochondrial splicing processes, RNA editing, rRNA processing, translation initia...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Lüking A,Stahl U,Schmidt U

更新日期：1998-01-01 00:00:00

abstract：:For more than a century amyloid was considered to be an interesting, unique, but inconsequential pathologic entity that rarely caused significant clinical problems. We now recognize that amyloid is not one entity. In vivo it is a uniform organization of a disease, or process, specific protein co-deposited with a set o...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Kisilevsky R,Fraser PE

更新日期：1997-01-01 00:00:00

abstract：:A protein is usually classified into one of the following five structural classes: alpha, beta, alpha + beta, alpha/beta, and zeta (irregular). The structural class of a protein is correlated with its amino acid composition. However, given the amino acid composition of a protein, how may one predict its structural cla...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Chou KC,Zhang CT

更新日期：1995-01-01 00:00:00

abstract：:This review focuses on how microbes live on CO as a sole source of carbon and energy and with CO by generating carbon monoxide as a metabolic intermediate. The use of CO is a property of organisms that use the Wood-L jungdahl pathway of autotrophic growth. The review discusses when CO metabolism originated, when and h...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Ragsdale SW

更新日期：2004-05-01 00:00:00

abstract：:The mevalonate-isoprenoid-cholesterol biosynthesis pathway plays a key role in human health and disease. The importance of this pathway is underscored by the discovery that two major isoprenoids, farnesyl and geranylgeranyl pyrophosphate, are required to modify an array of proteins through a process known as protein p...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Jeong A,Suazo KF,Wood WG,Distefano MD,Li L

更新日期：2018-06-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) constitute a family of more than 20 endopeptidases. Identification of specific matrix and non-matrix components as MMP substrates showed that, aside from their initial role as extracellular matrix modifiers, MMPs play significant roles in highly complex processes such as the regulation...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Cauwe B,Van den Steen PE,Opdenakker G

更新日期：2007-05-01 00:00:00

abstract：:Some asparagine and glutamine residues in proteins undergo deamidation to aspartate and glutamate with rates that depend upon the sequence and higher-order structure of the protein. Functional groups within the protein can catalyze this reaction, acting as general acids, bases, or stabilizers of the transition state. ...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Wright HT

更新日期：1991-01-01 00:00:00

abstract：:Rab GTPases are becoming increasingly implicated in neurodegenerative disorders, although their role in amyotrophic lateral sclerosis (ALS) has been somewhat overlooked. However, dysfunction of intracellular transport is gaining increasing attention as a pathogenic mechanism in ALS. Many previous studies have focused ...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Parakh S,Perri ER,Jagaraj CJ,Ragagnin AMG,Atkin JD

更新日期：2018-12-01 00:00:00

abstract：:FeII/alpha-ketoglutarate (alphaKG)-dependent hydroxylases catalyze an amazing diversity of reactions that result in protein side-chain modifications, repair of alkylated DNA/RNA, biosynthesis of antibiotics and plant products, metabolism related to lipids, and biodegradation of a variety of compounds. These enzymes po...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Hausinger RP

更新日期：2004-01-01 00:00:00

abstract：:DNA damaging agents have been a cornerstone of cancer therapy for nearly a century. The discovery of many of these chemicals, particularly the alkylating agents, are deeply entwined with the development of poisonous materials originally intended for use in warfare. Over the last decades, their anti-proliferative effec...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Tsao N,Schärer OD,Mosammaparast N

更新日期：2021-01-12 00:00:00

abstract：:Studies with biomimetic models can yield considerable insight into mechanisms of enzymatic catalysis. The discussion above indicates how such information has been important in the cases of flavoproteins, hemoproteins, and, to a lesser extent, the copper protein dopamine beta-hydroxylase. Some of the moieties that we g...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Guengerich FP

更新日期：1990-01-01 00:00:00

abstract：:The purpose of this review is to provide an analysis of the latest developments on the functions of the carbon catabolite-repression 4-Not (Ccr4-Not) complex in regulating eukaryotic gene expression. Ccr4-Not is a nine-subunit protein complex that is conserved in sequence and function throughout the eukaryotic kingdom...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Miller JE,Reese JC

更新日期：2012-07-01 00:00:00

abstract：:Type 1 protein phosphatases (PP-1) comprise a group of widely distributed enzymes that specifically dephosphorylate serine and threonine residues of certain phosphoproteins. They all contain an isoform of the same catalytic subunit, which has an extremely conserved primary structure. One of the properties of PP-1 that...

journal_title：Critical reviews in biochemistry and molecular biology

authors： Bollen M,Stalmans W

更新日期：1992-01-01 00:00:00