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Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults.

Abstract：

:Previous research in young adults has demonstrated that both motor learning and transcranial direct current stimulation (tDCS) trigger decreases in the levels of gamma-aminobutyric acid (GABA) in the sensorimotor cortex, and these decreases are linked to greater learning. Less is known about the role of GABA in motor learning in healthy older adults, a knowledge gap that is surprising given the established aging-related reductions in sensorimotor GABA. Here, we examined the effects of motor learning and subsequent tDCS on sensorimotor GABA levels and resting-state functional connectivity in the brains of healthy older participants. Thirty-six older men and women completed a motor sequence learning task before receiving anodal or sham tDCS to the sensorimotor cortex. GABA-edited magnetic resonance spectroscopy of the sensorimotor cortex and resting-state (RS) functional magnetic resonance imaging data were acquired before and after learning/stimulation. At the group level, neither learning nor anodal tDCS significantly modulated GABA levels or RS connectivity among task-relevant regions. However, changes in GABA levels from the baseline to post-learning session were significantly related to motor learning magnitude, age, and baseline GABA. Moreover, the change in functional connectivity between task-relevant regions, including bilateral motor cortices, was correlated with baseline GABA levels. These data collectively indicate that motor learning-related decreases in sensorimotor GABA levels and increases in functional connectivity are limited to those older adults with higher baseline GABA levels and who learn the most. Post-learning tDCS exerted no influence on GABA levels, functional connectivity or the relationships among these variables in older adults.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

King BR,Rumpf JJ,Verbaanderd E,Heise KF,Dolfen N,Sunaert S,Doyon J,Classen J,Mantini D,Puts NAJ,Edden RAE,Albouy G,Swinnen SP

doi

10.1002/hbm.25041

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

3680-3695

issue

eissn

1065-9471

issn

1097-0193

journal_volume

pub_type

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Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults.