Abstract:
BACKGROUND:While acceleration in age-related cerebral atrophy has been well documented in Alzheimer's disease, the cerebellar contributions to this effect have not been thoroughly investigated. OBJECTIVE:This study investigated cerebellar volume and atrophy rate using magnetic resonance imaging in individuals with normal cognition (CN), mild cognitive impairment (MCI), and Alzheimer's disease (AD). METHODS:Two hundred twenty-nine CN, 398 MCI and 191 AD participants of stage I ADNI database with screening scans were evaluated for cerebellar volume. Of those, 758 individuals with two or more follow-up scans were categorized into stable, converted, and reverted CN, MCI and AD and evaluated for cerebellar atrophy rate. RESULTS:Cerebellar volume was 2.5% larger in CN than in those with AD but there were no differences between CN and MCI and MCI and AD in cross-sectional analysis. Similarly, the atrophy rate was 49% larger in AD and 64% larger in MCI who converted to AD but no difference was detected between CN and MCI. There were no association between education and APOEe4 and cerebellar volume or cerebellar atrophy across the diagnostic groups. CONCLUSION:Cerebellar atrophy contributes to Alzheimer's clinical progression but mostly at the late stage of the disease. However, even in the late stage shrinkage rate is less than the average of the shrinkage in the cerebrum and is not associated with AD moderators. This suggests that cerebellar involvement is secondary to cerebral involvement and can be due to network connection spread regardless of the primary pathology. Hum Brain Mapp, 2017. © 2017 Wiley Periodicals, Inc. Hum Brain Mapp 38:3141-3150, 2017. © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. Hum Brain Mapp 38:3141-3150, 2017. © 2017 Wiley Periodicals, Inc.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Tabatabaei-Jafari H,Walsh E,Shaw ME,Cherbuin N,Alzheimer's Disease Neuroimaging Initiative (ADNI).doi
10.1002/hbm.23580subject
Has Abstractpub_date
2017-06-01 00:00:00pages
3141-3150issue
6eissn
1065-9471issn
1097-0193journal_volume
38pub_type
杂志文章abstract::During the last 20 years, predictive modeling in epilepsy research has largely been concerned with the prediction of seizure events, whereas the inference of effective brain targets for resective surgery has received surprisingly little attention. In this exploratory pilot study, we describe a distributional clusterin...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23537
更新日期:2017-05-01 00:00:00
abstract::It is becoming common to collect data from multiple functional magnetic resonance imaging (fMRI) paradigms on a single individual. The data from these experiments are typically analyzed separately and sometimes directly subtracted from one another on a voxel-by-voxel basis. These comparative approaches, although usefu...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20204
更新日期:2006-07-01 00:00:00
abstract::Resection of the seizure generating tissue can be highly beneficial in patients with drug-resistant epilepsy. However, only about half of all patients undergoing surgery get permanently and completely seizure free. Investigating the dependences between intracranial EEG signals adds a multivariate perspective largely u...
journal_title:Human brain mapping
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
abstract::Standard procedures to achieve quality assessment (QA) of functional magnetic resonance imaging (fMRI) data are of great importance. A standardized and fully automated procedure for QA is presented that allows for classification of data quality and the detection of artifacts by inspecting temporal variations. The appl...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20096
更新日期:2005-06-01 00:00:00
abstract::The luminance contrast of a visual stimulus is known to modulate the response properties of areas V1 and the human MT complex (hMT+), but has not been shown to modulate interactions between these two areas. We examined the direction of information transfer between V1/V2 and hMT+ at different stimulus contrasts by meas...
journal_title:Human brain mapping
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
abstract::Diffusion tensor imaging (DTI) can be used to index white matter integrity of the corticospinal tract (CST) after stroke; however, the psychometric properties of DTI-based measures of white matter integrity are unknown. The purpose of this study was to examine test-retest reliability as determined by intraclass correl...
journal_title:Human brain mapping
pub_type: 杂志文章
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abstract::Listening to music can induce us to tune in to its beat. Previous neuroimaging studies have shown that the motor system becomes involved in perceptual rhythm and timing tasks in general, as well as during preference-related responses to music. However, the role of preferred rhythm and, in particular, of preferred beat...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20844
更新日期:2010-01-01 00:00:00
abstract::Verbal stimuli often induce right-hemispheric activation in patients with aphasia after left-hemispheric stroke. This right-hemispheric activation is commonly attributed to functional reorganization within the language system. Yet previous evidence suggests that functional activation in right-hemispheric homologues of...
journal_title:Human brain mapping
pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
abstract::Studies of the neural basis of intelligence have focused on comparing brain imaging variables with global scales instead of the cognitive domains integrating these scales or quotients. Here, the relation between mean tract-based fractional anisotropy (mTBFA) and intelligence indices was explored. Deterministic tractog...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24848
更新日期:2020-03-01 00:00:00
abstract::Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) are important tools in cognitive and clinical neuroscience. Combined EEG-fMRI has been shown to help to characterise brain networks involved in epileptic activity, as well as in different sensory, motor and cognitive functions. A good unders...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.22623
更新日期:2015-01-01 00:00:00
abstract::MR-based measurements of brain volumes may be affected by the presence of white matter (WM) lesions. Here, we assessed how and to what extent this may happen for WM lesions of various sizes and intensities. After inserting WM lesions of different sizes and intensities into T1-W brain images of healthy subjects, we ass...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21344
更新日期:2012-09-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) studies have shown notable age-dependent differences in reward processing. We analyzed data from a total of 554 children, 1,059 adolescents, and 1,831 adults from 70 articles. Quantitative meta-analyses results show that adults engage an extended set of regions that include...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25103
更新日期:2020-10-01 00:00:00
abstract::Working memory (WM) performance is very often measured using the n-back task, in which the participant is presented with a sequence of stimuli, and required to indicate whether the current stimulus matches the one presented n steps earlier. In this study, we used high-density electroencephalography (hdEEG) coupled to ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25283
更新日期:2020-11-17 00:00:00
abstract::With the causes of perinatal brain injuries still unclear and the probable role of hemodynamic instability in their etiology, bedside monitoring of neonatal cerebral hemodynamics with standard values as a function of age are needed. In this study, we combined quantitative frequency domain near infrared spectroscopy (F...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20868
更新日期:2010-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24796
更新日期:2020-01-01 00:00:00
abstract::Mirror neurons, originally described in the monkey premotor area F5, are embedded in a frontoparietal network for action execution and observation. A similar Mirror Neuron System (MNS) exists in humans, including precentral gyrus, inferior parietal lobule, and superior temporal sulcus. Controversial is the inclusion o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22682
更新日期:2015-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20333
更新日期:2007-10-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24564
更新日期:2019-07-01 00:00:00
abstract::Benign epilepsy with centrotemporal spikes (BECTS) is characterized by abnormal (static) functional interactions among cortical and subcortical regions, regardless of the active or chronic epileptic state. However, human brain connectivity is dynamic and associated with ongoing rhythmic activity. The dynamic functiona...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23910
更新日期:2018-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24078
更新日期:2018-08-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24362
更新日期:2019-01-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22276
更新日期:2014-04-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22654
更新日期:2015-02-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24679
更新日期:2019-09-01 00:00:00
abstract::Musical expertise is visible both in the morphology and functionality of the brain. Recent research indicates that functional integration between multi-sensory, somato-motor, default-mode (DMN), and salience (SN) networks of the brain differentiates musicians from non-musicians during resting state. Here, we aimed at ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23565
更新日期:2017-06-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20448
更新日期:2008-09-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25088
更新日期:2020-09-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23418
更新日期:2017-02-01 00:00:00