Modular-level alterations of structure-function coupling in schizophrenia connectome.

Abstract:

:Convergent evidences have revealed that schizophrenia is associated with brain dysconnectivity, which leads to abnormal network organization. However, discrepancies were apparent between the structural connectivity (SC) and functional connectivity (FC) studies, and the relationship between structural and functional deficits in schizophrenia remains largely unknown. In this study, resting-state functional magnetic resonance imaging and structural diffusion tensor imaging were performed in 20 patients with schizophrenia and 20 matched healthy volunteers (patients/controls = 19/17 after head motion rejection). Functional and structural brain networks were obtained for each participant. Graph theoretical approaches were employed to parcellate the FC networks into functional modules. The relationships between the entries of SC and FC were estimated within each module to identify group differences and their correlations with clinical symptoms. Although five common functional modules (including the default mode, occipital, subcortical, frontoparietal, and central modules) were identified in both groups, the patients showed a significantly reduced modularity in comparison with healthy participants. Furthermore, we found that schizophrenia-related aberrations of SC-FC coupling exhibited complex patterns among modules. Compared with controls, patients showed an increased SC-FC coupling in the default mode and the central modules. Moreover, significant SC-FC decoupling was demonstrated in the occipital and the subcortical modules, which was associated with longer duration of illness and more severe clinical manifestations of schizophrenia. Taken together, these findings demonstrated that altered module-dependent SC-FC coupling may underlie abnormal brain function and clinical symptoms observed in schizophrenia and highlighted the potential for using new multimodal neuroimaging biomarkers for diagnosis and severity evaluation of schizophrenia. Hum Brain Mapp 38:2008-2025, 2017. © 2017 Wiley Periodicals, Inc.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Sun Y,Dai Z,Li J,Collinson SL,Sim K

doi

10.1002/hbm.23501

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

2008-2025

issue

4

eissn

1065-9471

issn

1097-0193

journal_volume

38

pub_type

杂志文章
  • Characterizing hippocampal dynamics with MEG: A systematic review and evidence-based guidelines.

    abstract::The hippocampus, a hub of activity for a variety of important cognitive processes, is a target of increasing interest for researchers and clinicians. Magnetoencephalography (MEG) is an attractive technique for imaging spectro-temporal aspects of function, for example, neural oscillations and network timing, especially...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24445

    authors: Ruzich E,Crespo-García M,Dalal SS,Schneiderman JF

    更新日期:2019-03-01 00:00:00

  • Mapping structural differences of the corpus callosum in individuals with 18q deletions using targetless regional spatial normalization.

    abstract::Individuals with a constitutional chromosome abnormality consisting of a deletion of a portion of the long arm of chromosome 18 (18q-) have a high incidence ( approximately 95%) of dysmyelination. Neuroradiologic findings in affected children report a smaller corpus callosum, but this finding has not been quantified. ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20090

    authors: Kochunov P,Lancaster J,Hardies J,Thompson PM,Woods RP,Cody JD,Hale DE,Laird A,Fox PT

    更新日期:2005-04-01 00:00:00

  • Free water elimination improves test-retest reproducibility of diffusion tensor imaging indices in the brain: A longitudinal multisite study of healthy elderly subjects.

    abstract::Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity in human white matter characterization both in health and in disease. Relative to the classical diffusion tensor imaging (DTI) model, FWE is also expected to increase sensitivity to microstructural changes in longitudinal ...

    journal_title:Human brain mapping

    pub_type: 杂志文章,多中心研究

    doi:10.1002/hbm.23350

    authors: Albi A,Pasternak O,Minati L,Marizzoni M,Bartrés-Faz D,Bargalló N,Bosch B,Rossini PM,Marra C,Müller B,Fiedler U,Wiltfang J,Roccatagliata L,Picco A,Nobili FM,Blin O,Sein J,Ranjeva JP,Didic M,Bombois S,Lopes R,Bord

    更新日期:2017-01-01 00:00:00

  • BrainMap VBM: An environment for structural meta-analysis.

    abstract::The BrainMap database is a community resource that curates peer-reviewed, coordinate-based human neuroimaging literature. By pairing the results of neuroimaging studies with their relevant meta-data, BrainMap facilitates coordinate-based meta-analysis (CBMA) of the neuroimaging literature en masse or at the level of e...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24078

    authors: Vanasse TJ,Fox PM,Barron DS,Robertson M,Eickhoff SB,Lancaster JL,Fox PT

    更新日期:2018-08-01 00:00:00

  • A comparison of Granger causality and coherency in fMRI-based analysis of the motor system.

    abstract::The ability of functional MRI to acquire data from multiple brain areas has spurred developments not only in voxel-by-voxel analyses, but also in multivariate techniques critical to quantifying the interactions between brain areas. As the number of multivariate techniques multiplies, however, few studies in any modali...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20771

    authors: Kayser AS,Sun FT,D'Esposito M

    更新日期:2009-11-01 00:00:00

  • Three-dimensional surface deformation-based shape analysis of hippocampus and caudate nucleus in children with fetal alcohol spectrum disorders.

    abstract::Surface deformation-based analysis was used to assess local shape variations in the hippocampi and caudate nuclei of children with fetal alcohol spectrum disorders. High-resolution structural magnetic resonance imaging images were acquired for 31 children (19 controls and 12 children diagnosed with fetal alcohol syndr...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22209

    authors: Joseph J,Warton C,Jacobson SW,Jacobson JL,Molteno CD,Eicher A,Marais P,Phillips OR,Narr KL,Meintjes EM

    更新日期:2014-02-01 00:00:00

  • Altered neural signatures of interoception in multiple sclerosis.

    abstract::Multiple sclerosis (MS) patients present several alterations related to sensing of bodily signals. However, no specific neurocognitive impairment has yet been proposed as a core deficit underlying such symptoms. We aimed to determine whether MS patients present changes in interoception-that is, the monitoring of auton...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24319

    authors: Salamone PC,Esteves S,Sinay VJ,García-Cordero I,Abrevaya S,Couto B,Adolfi F,Martorell M,Petroni A,Yoris A,Torquati K,Alifano F,Legaz A,Cassará FP,Bruno D,Kemp AH,Herrera E,García AM,Ibáñez A,Sedeño L

    更新日期:2018-12-01 00:00:00

  • Heritability of "small-world" networks in the brain: a graph theoretical analysis of resting-state EEG functional connectivity.

    abstract::Recent studies have shown that resting-state functional networks as studied with fMRI, EEG, and MEG may be so-called small-world networks. We investigated to what extent the characteristic features of small-world networks are genetically determined. To represent functional connectivity between brain areas, we measured...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20468

    authors: Smit DJ,Stam CJ,Posthuma D,Boomsma DI,de Geus EJ

    更新日期:2008-12-01 00:00:00

  • Free-water and BOLD imaging changes in Parkinson's disease patients chronically treated with a MAO-B inhibitor.

    abstract::Rasagiline is a monoamine oxidase type B inhibitor that possesses no amphetamine-like properties, and provides symptomatic relief in early and late stages of Parkinson's disease (PD). Data in animal models of PD suggest that chronic administration of rasagiline is associated with structural changes in the substantia n...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23213

    authors: Burciu RG,Ofori E,Shukla P,Pasternak O,Chung JW,McFarland NR,Okun MS,Vaillancourt DE

    更新日期:2016-08-01 00:00:00

  • Individual variability in the shape and amplitude of the BOLD-HRF correlates with endogenous GABAergic inhibition.

    abstract::It has previously been demonstrated that there is a negative correlation between the amplitude of the BOLD response and resting γ amino-butyric acid (GABA) concentration in visual cortex. The work here is the first to empirically characterize individual variability in the haemodynamic response functions (HRFs) in resp...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21223

    authors: Muthukumaraswamy SD,Evans CJ,Edden RA,Wise RG,Singh KD

    更新日期:2012-02-01 00:00:00

  • A technical review of canonical correlation analysis for neuroscience applications.

    abstract::Collecting comprehensive data sets of the same subject has become a standard in neuroscience research and uncovering multivariate relationships among collected data sets have gained significant attentions in recent years. Canonical correlation analysis (CCA) is one of the powerful multivariate tools to jointly investi...

    journal_title:Human brain mapping

    pub_type: 杂志文章,评审

    doi:10.1002/hbm.25090

    authors: Zhuang X,Yang Z,Cordes D

    更新日期:2020-09-01 00:00:00

  • Expertise modulates the neural basis of context dependent recognition of objects and their relations.

    abstract::Recognition of objects and their relations is necessary for orienting in real life. We examined cognitive processes related to recognition of objects, their relations, and the patterns they form by using the game of chess. Chess enables us to compare experts with novices and thus gain insight in the nature of developm...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21396

    authors: Bilalić M,Turella L,Campitelli G,Erb M,Grodd W

    更新日期:2012-11-01 00:00:00

  • Evidence of frontotemporal structural hypoconnectivity in social anxiety disorder: A quantitative fiber tractography study.

    abstract::Investigation of the brain's white matter fiber tracts in social anxiety disorder (SAD) may provide insight into the underlying pathophysiology. Because models of pathological anxiety posit altered frontolimbic interactions, the uncinate fasciculus (UF) connecting (orbito-) frontal and temporal areas including the amy...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21447

    authors: Baur V,Brühl AB,Herwig U,Eberle T,Rufer M,Delsignore A,Jäncke L,Hänggi J

    更新日期:2013-02-01 00:00:00

  • Cognitive processing in Chinese literate and illiterate subjects: an fMRI study.

    abstract::Functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) were used to map brain activation during language tasks. While previous studies have compared performance between alphabetic literate and illiterate subjects, there have been no such data in Chinese-speaking individuals. In this study,...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20173

    authors: Li G,Cheung RT,Gao JH,Lee TM,Tan LH,Fox PT,Jack CR Jr,Yang ES

    更新日期:2006-02-01 00:00:00

  • Reduced fronto-callosal fiber integrity in unmedicated OCD patients: a diffusion tractography study.

    abstract::It is widely accepted that abnormalities in the frontal area of the brain underpin the pathophysiology of obsessive-compulsive disorder (OCD). Fundamental to this investigation is the delineation of frontal white matter tracts including dorsal and ventral frontal projections of interhemispheric connections. While prev...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21372

    authors: Oh JS,Jang JH,Jung WH,Kang DH,Choi JS,Choi CH,Kubicki M,Shenton ME,Kwon JS

    更新日期:2012-10-01 00:00:00

  • Brain structural correlates of irritability: Findings in a large healthy cohort.

    abstract::Irritability and nonviolent aggression are common behavioral features across the population, yet there is limited neurobiological research into subclinical phenotypes representing the lower edge of a symptom continuum ranging from slight irritability to criminal violence. We studied brain structural correlates of irri...

    journal_title:Human brain mapping

    pub_type: 杂志文章,多中心研究

    doi:10.1002/hbm.23824

    authors: Besteher B,Squarcina L,Spalthoff R,Bellani M,Gaser C,Brambilla P,Nenadić I

    更新日期:2017-12-01 00:00:00

  • Direct replication of task-dependent neural activation patterns during sadness introspection in two independent adolescent samples.

    abstract::Functional neuroimaging results need to replicate to inform sound models of human social cognition and its neural correlates. Introspection, the capacity to reflect on one's thoughts and feelings, is one process required for normative social cognition and emotional functioning. Engaging in introspection draws on a net...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24836

    authors: Vilgis V,Rhoads SA,Weissman DG,Gelardi KL,Forbes EE,Hipwell AE,Keenan K,Hastings PD,Guyer AE

    更新日期:2020-02-15 00:00:00

  • Coordinate-based (ALE) meta-analysis of brain activation in patients with fibromyalgia.

    abstract::There are an increasing number of neuroimaging studies that allow a better understanding of symptoms, neural correlates and associated conditions of fibromyalgia. However, the results of these studies are difficult to compare, as they include a heterogeneous group of patients, use different stimulation paradigms, task...

    journal_title:Human brain mapping

    pub_type: 杂志文章,meta分析

    doi:10.1002/hbm.23132

    authors: Dehghan M,Schmidt-Wilcke T,Pfleiderer B,Eickhoff SB,Petzke F,Harris RE,Montoya P,Burgmer M

    更新日期:2016-05-01 00:00:00

  • Cortical localization of phase and amplitude dynamics predicting access to somatosensory awareness.

    abstract::Neural dynamics leading to conscious sensory perception have remained enigmatic in despite of large interest. Human functional magnetic resonance imaging (fMRI) studies have revealed that a co-activation of sensory and frontoparietal areas is crucial for conscious sensory perception in the several second time-scale of...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23033

    authors: Hirvonen J,Palva S

    更新日期:2016-01-01 00:00:00

  • Hippocampal BOLD response during category learning predicts subsequent performance on transfer generalization.

    abstract::To test a prediction of our previous computational model of cortico-hippocampal interaction (Gluck and Myers [1993, 2001]) for characterizing individual differences in category learning, we studied young healthy subjects using an fMRI-adapted category-learning task that has two phases, an initial phase in which associ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22389

    authors: Fera F,Passamonti L,Herzallah MM,Myers CE,Veltri P,Morganti G,Quattrone A,Gluck MA

    更新日期:2014-07-01 00:00:00

  • Neural basis of the non-attentional processing of briefly presented words.

    abstract::The neural basis of the automatic activation of words was investigated in an fMRI study. In the study, words were presented briefly (51 or 151 msec) followed by a mask. To prevent attentional processing, subjects attended to the masks and not the words, and were required to make perceptual judgment about the masks. We...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.10096

    authors: Peng DL,Xu D,Jin Z,Luo Q,Ding GS,Perry C,Zhang L,Liu Y

    更新日期:2003-03-01 00:00:00

  • Directional functional coupling of cerebral rhythms between anterior cingulate and dorsolateral prefrontal areas during rare stimuli: a directed transfer function analysis of human depth EEG signal.

    abstract::What is the neural substrate of our capability to properly react to changes in the environment? It can be hypothesized that the anterior cingulate cortex (ACC) manages repetitive stimuli in routine conditions and alerts the dorsolateral prefrontal cortex (PFC) when stimulation unexpectedly changes. To provide evidence...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20491

    authors: Brázdil M,Babiloni C,Roman R,Daniel P,Bares M,Rektor I,Eusebi F,Rossini PM,Vecchio F

    更新日期:2009-01-01 00:00:00

  • Constructing and evaluating a cortical surface atlas and analyzing cortical sex differences in young Chinese adults.

    abstract::Cortical surface templates are an important standardized coordinate frame for cortical structure and function analysis in magnetic resonance (MR) imaging studies. The widely used adult cortical surface templates (e.g., fsaverage, Conte69, and the HCP-MMP atlas) are based on the Caucasian population. Neuroanatomical di...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24960

    authors: Yang G,Bozek J,Han M,Gao JH

    更新日期:2020-06-15 00:00:00

  • A novel method for integrating MEG and BOLD fMRI signals with the linear convolution model in human primary somatosensory cortex.

    abstract::Characterizing the neurovascular coupling between hemodynamic signals and their neural origins is crucial to functional neuroimaging research, even more so as new methods become available for integrating results from different functional neuroimaging modalities. We present a novel method to relate magnetoencephalograp...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20361

    authors: Nangini C,Tam F,Graham SJ

    更新日期:2008-01-01 00:00:00

  • Attentional modulation of reward processing in the human brain.

    abstract::Although neural signals of reward anticipation have been studied extensively, the functional relationship between reward and attention has remained unclear: Neural signals implicated in reward processing could either reflect attentional biases towards motivationally salient stimuli, or proceed independently of attenti...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22383

    authors: Rothkirch M,Schmack K,Deserno L,Darmohray D,Sterzer P

    更新日期:2014-07-01 00:00:00

  • Detecting bilateral abnormalities with voxel-based morphometry.

    abstract::In this article we describe a new method, using SPM99, that searches explicitly for bilateral structural abnormalities. Children with bilateral pathology have a poorer prognosis than children with unilateral damage. After brain injury or disease in childhood, it is thought that rescue of function is only possible if t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:

    authors: Salmond CH,Ashburner J,Vargha-Khadem F,Gadian DG,Friston KJ

    更新日期:2000-11-01 00:00:00

  • I lie, why don't you: Neural mechanisms of individual differences in self-serving lying.

    abstract::People tend to lie in varying degrees. To advance our understanding of the underlying neural mechanisms of this heterogeneity, we investigated individual differences in self-serving lying. We performed a functional magnetic resonance imaging study in 37 participants and introduced a color-reporting game where lying ab...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24432

    authors: Yin L,Weber B

    更新日期:2019-03-01 00:00:00

  • Sex-differences in network level brain dynamics associated with pain sensitivity and pain interference.

    abstract::Neural dynamics can shape human experience, including pain. Pain has been linked to dynamic functional connectivity within and across brain regions of the dynamic pain connectome (consisting of the ascending nociceptive pathway (Asc), descending antinociceptive pathway (Desc), salience network (SN), and the default mo...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25245

    authors: Kim JA,Bosma RL,Hemington KS,Rogachov A,Osborne NR,Cheng JC,Dunkley BT,Davis KD

    更新日期:2021-02-15 00:00:00

  • Attentional load modifies early activity in human primary visual cortex.

    abstract::Recent theories of selective attention assume that the more attention is required by a task, the earlier are irrelevant stimuli filtered during perceptual processing. Previous functional MRI studies have demonstrated that primary visual cortex (V1) activation by peripheral distractors is reduced by higher task difficu...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20636

    authors: Rauss KS,Pourtois G,Vuilleumier P,Schwartz S

    更新日期:2009-05-01 00:00:00

  • Exploring the unity and diversity of the neural substrates of executive functioning.

    abstract::Previous studies exploring the neural substrates of executive functioning used task-specific analyses, which might not be the most appropriate approach due to the difficulty of precisely isolating executive functions. Consequently, the aim of this study was to use positron emission tomography (PET) to reexamine by con...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20118

    authors: Collette F,Van der Linden M,Laureys S,Delfiore G,Degueldre C,Luxen A,Salmon E

    更新日期:2005-08-01 00:00:00