Sex-differences in network level brain dynamics associated with pain sensitivity and pain interference.

Abstract:

:Neural dynamics can shape human experience, including pain. Pain has been linked to dynamic functional connectivity within and across brain regions of the dynamic pain connectome (consisting of the ascending nociceptive pathway (Asc), descending antinociceptive pathway (Desc), salience network (SN), and the default mode network (DMN)), and also shows sex differences. These linkages are based on fMRI-derived slow hemodynamics. Here, we utilized the fine temporal resolution of magnetoencephalography (MEG) to measure resting state functional coupling (FCp) related to individual pain perception and pain interference in 50 healthy individuals (26 women, 24 men). We found that pain sensitivity and pain interference were linked to within- and cross-network broadband FCp across the Asc and SN. We also identified sex differences in these relationships: (a) women exhibited greater within-network static FCp, whereas men had greater dynamic FCp within the dynamic pain connectome; (b) relationship between pain sensitivity and pain interference with FCp in women was commonly found in theta, whereas in men, these relationships were predominantly in the beta and low gamma bands. These findings indicate that dynamic interactions of brain networks underlying pain involve fast brain communication in men but slower communication in women.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Kim JA,Bosma RL,Hemington KS,Rogachov A,Osborne NR,Cheng JC,Dunkley BT,Davis KD

doi

10.1002/hbm.25245

subject

Has Abstract

pub_date

2021-02-15 00:00:00

pages

598-614

issue

3

eissn

1065-9471

issn

1097-0193

journal_volume

42

pub_type

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