Abstract:
:Depressive symptoms often coexist with memory deficits in older adults and also are associated with incident cognitive decline in the elderly. However, little is known about the neural correlates of the association between depressive symptoms and memory deficits in nondemented elderly. Fifteen amnestic mild cognitive impairment (aMCI) and 20 cognitively normal (CN) subjects completed resting-state functional magnetic resonance imaging (R-fMRI) scans. Multiple linear regression analysis was performed to test the main effects of the Geriatric Depression Scale (GDS) and Rey Auditory Verbal Learning Test delayed recall (RAVLT-DR) scores, and their interaction on the intrinsic amygdala functional connectivity (AFC) network activity. Severer depressive symptoms and memory deficits were found in the aMCI group than in the CN group. Partial correlation analysis identified that the RAVLT-DR scores were significantly correlated with the AFC network in the bilateral dorsolateral prefrontal cortex (DLPFC), dorsomedial and anterior prefrontal cortex, posterior cingulate cortex (PCC), middle occipital gyrus, right inferior parietal cortex, and left middle temporal gyrus (MTG). The GDS scores were positively correlated with the AFC network in the bilateral PCC and MTG, and left DLPFC. The interactive effects of the GDS and RAVLT-DR scores on the AFC network were seen in the bilateral PCC, MTG, and left DLPFC. These findings not only supported that there were interactive neural links between depressive symptoms and memory functions in nondemented elderly at the system level, but also demonstrated that R-fMRI has advantages in investigating the interactive nature of different neural networks involved in complex functions, such as emotion and cognition.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Xie C,Goveas J,Wu Z,Li W,Chen G,Franczak M,Antuono PG,Jones JL,Zhang Z,Li SJdoi
10.1002/hbm.21291subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1352-63issue
6eissn
1065-9471issn
1097-0193journal_volume
33pub_type
杂志文章abstract::Mind wandering (MW) has become a prominent topic of neuroscientific investigation due to the importance of understanding attentional processes in our day-to-day experiences. Emerging evidence suggests a critical role for three large-scale brain networks in MW: the default network (DN), the central executive network (C...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24721
更新日期:2019-10-15 00:00:00
abstract::Cognitive processing speed is crucial for human cognition and declines with aging. White matter hyperintensity (WMH), a common sign of WM vascular damage in the elderly, is closely related to slower psychomotor processing speed. In this study, we investigated the association between WMH and psychomotor speed changes t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24826
更新日期:2020-02-15 00:00:00
abstract::The nuclei of the human amygdala remain difficult to distinguish in individual subject structural magnetic resonance images. However, interpretation of the amygdala's role in whole brain networks requires accurate localization of functional activity to a particular nucleus or subgroup of nuclei. To address this, high ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23289
更新日期:2016-11-01 00:00:00
abstract::Linking observed and executable actions appears to be achieved by an action observation network (AON), comprising parietal, premotor, and occipitotemporal cortical regions of the human brain. AON engagement during action observation is thought to aid in effortless, efficient prediction of ongoing movements to support ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21450
更新日期:2013-02-01 00:00:00
abstract::Dopaminergic degeneration is a hallmark of Parkinson's disease (PD), which causes various symptoms affected by corticostriatal circuits. So far, the relationship between cortical changes and dopamine loss in the striatum is unclear. Here, we evaluate the gray matter (GM) changes in accordance with striatal dopaminergi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23130
更新日期:2016-05-01 00:00:00
abstract::Verbal stimuli often induce right-hemispheric activation in patients with aphasia after left-hemispheric stroke. This right-hemispheric activation is commonly attributed to functional reorganization within the language system. Yet previous evidence suggests that functional activation in right-hemispheric homologues of...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21512
更新日期:2013-06-01 00:00:00
abstract::Artificial percepts (phosphenes) can be induced by applying transcranial magnetic stimulation (TMS) over human visual cortex. Although phosphenes have been used to study visual awareness, the neural mechanisms generating them have not yet been delineated. We directly tested the two leading hypotheses of how phosphenes...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20941
更新日期:2010-09-01 00:00:00
abstract::The reason why human beings are inclined to overestimate the duration of highly arousing negative events remains enigmatic. The issue about what neurocognitive mechanisms and neural structures support the connection between time perception and emotion was addressed here by an event-related neuroimaging study involving...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22680
更新日期:2015-03-01 00:00:00
abstract::Humans make various kinds of decisions about which emotions they perceive from others. Although it might seem like a split-second phenomenon, deliberating over which emotions we perceive unfolds across several stages of decisional processing. Neurocognitive models of general perception postulate that our brain first e...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.24893
更新日期:2020-04-15 00:00:00
abstract::The hypothalamus is of enormous importance for multiple bodily functions such as energy homeostasis. Especially, rodent studies have greatly contributed to our understanding how specific hypothalamic subregions integrate peripheral and central signals into the brain to control food intake. In humans, however, the neur...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22607
更新日期:2014-12-01 00:00:00
abstract::Human brain mapping allows the systematic assessment of interindividual differences in functional brain anatomy. Functional transcranial Doppler sonography (fTCD) is an imaging tool that allows for fast and mobile assessment of hemispheric lateralization of task-related brain activation. It is ideal to screen large co...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20055
更新日期:2004-11-01 00:00:00
abstract::Increased cerebral blood flow in the anterior cingulate cortex (ACC) has been noted in a range of cognitively demanding tasks studied with PET. A PET study of 10 normal males was carried out using the bolus H2(15)O intravenous injection technique to examine the effects of anticipation on blood flow to the ACC. In a se...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1996)4:2<103::AID-HBM2>3.0
更新日期:1996-01-01 00:00:00
abstract::Working memory (WM) for auditory information has been thought of as a unitary system, but whether WM for verbal and tonal information relies on the same or different functional neuroarchitectures has remained unknown. This fMRI study examines verbal and tonal WM in both nonmusicians (who are trained in speech, but not...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21060
更新日期:2011-05-01 00:00:00
abstract::In the absence of vision, spatial representation may be altered. When asked to compare the relative distances between three sounds (i.e., auditory spatial bisection task), blind individuals demonstrate significant deficits and do not show an event-related potential response mimicking the visual C1 reported in sighted ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24931
更新日期:2020-06-01 00:00:00
abstract::Conflict monitoring and motor inhibition are engaged in the performance of complex tasks. The midcingulate cortex (MCC) has been suggested to detect conflicts, whereas the right inferior frontal cortex (IFC) seems to be of relevance for the inhibition process. The current experiment investigates the neural underpinnin...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22002
更新日期:2013-07-01 00:00:00
abstract::The results of most neuroimaging studies are reported in volumetric (e.g., MNI152) or surface (e.g., fsaverage) coordinate systems. Accurate mappings between volumetric and surface coordinate systems can facilitate many applications, such as projecting fMRI group analyses from MNI152/Colin27 to fsaverage for visualiza...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24213
更新日期:2018-09-01 00:00:00
abstract::Neural dynamics can shape human experience, including pain. Pain has been linked to dynamic functional connectivity within and across brain regions of the dynamic pain connectome (consisting of the ascending nociceptive pathway (Asc), descending antinociceptive pathway (Desc), salience network (SN), and the default mo...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25245
更新日期:2021-02-15 00:00:00
abstract::Brain activity was studied with fMRI and steady-state visual evoked potentials (SSVEPs) in separate sessions as subjects attended to letter sequences in either the right or left visual field. The two letter sequences were superimposed on small square backgrounds that flickered at 8.6 and 12.0 Hz, respectively, and eli...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1997)5:4<287::AID-HBM14>3.
更新日期:1997-01-01 00:00:00
abstract::Electrophysiological signals recorded intracranially show rich frequency content spanning from near-DC to hundreds of hertz. Noninvasive electromagnetic signals measured with electroencephalography (EEG) or magnetoencephalography (MEG) typically contain less signal power in high frequencies than invasive recordings. P...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24795
更新日期:2020-01-01 00:00:00
abstract::Playing music requires a strong coupling of perception and action mediated by multimodal integration of brain regions, which can be described as network connections measured by anatomical and functional correlations between regions. However, the structural and functional connectivities within and between the auditory ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23989
更新日期:2018-05-01 00:00:00
abstract::Classically, model-based segmentation procedures match magnetic resonance imaging (MRI) volumes to an expertly labeled atlas using nonlinear registration. The accuracy of these techniques are limited due to atlas biases, misregistration, and resampling error. Multi-atlas-based approaches are used as a remedy and invol...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22092
更新日期:2013-10-01 00:00:00
abstract::Ventromedial regions of the frontal lobe (vmFL) are thought to play a key role in decision-making and emotional regulation. However, aspects of this area's functional organization, including the presence of a multiple subregions, their functional and anatomical connectivity, and the cross-species homologies of these s...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25014
更新日期:2020-08-15 00:00:00
abstract::The presence of white matter lesions in patients with cerebral small vessel disease (SVD) is among the main causes of cognitive decline. We investigated the relation between white matter hyperintensity (WMH) locations and executive and language abilities in 442 SVD patients without dementia with varying burden of WMH....
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25273
更新日期:2020-11-24 00:00:00
abstract::Apathy, common in neurological disorders, is defined as disinterest and loss of motivation, with a reduction in self-initiated activity. Research in diseased populations has shown that apathy is associated with variations in the volume of brain regions such as the anterior cingulate and the frontal lobes. The goal of ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22225
更新日期:2014-03-01 00:00:00
abstract::Although elevated serum high-sensitivity C-reactive protein (hsCRP) is related to atherosclerosis, brain infarction, and cognitive decline, it has not been clarified whether increased hsCRP is associated with the decline in brain gray matter volume. Therefore, the purpose of this study was to determine the relationshi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22073
更新日期:2013-10-01 00:00:00
abstract::The TREK1 gene has been linked to a depression-resistant phenotype in rodents and antidepressant response in humans, but the neural mechanisms underlying these links are unclear. Because TREK1 is expressed in reward-related basal ganglia regions, it has been hypothesized that TREK1 genetic variation may be associated ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20858
更新日期:2010-02-01 00:00:00
abstract::From birth to 5 years of age, brain structure matures and evolves alongside emerging cognitive and behavioral abilities. In relating concurrent cognitive functioning and measures of brain structure, a major challenge that has impeded prior investigation of their time-dynamic relationships is the sparse and irregular n...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24690
更新日期:2019-10-01 00:00:00
abstract::Whether neuroimaging findings support discriminable neural correlates of emotion categories is a longstanding controversy. Two recent meta-analyses arrived at opposite conclusions, with one supporting (Vytal and Hamann []: J Cogn Neurosci 22:2864-2885) and the other opposing this proposition (Lindquist et al. []: Beha...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22910
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Early life trauma (ELT) is a significant risk factor for the onset of depression. Emerging findings indicate ELT is associated with enhanced amygdala reactivity to aversive stimuli in never-depressed healthy controls as well as those with acute depression but may be absent in non-ELT exposed depressed. The pr...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22514
更新日期:2014-09-01 00:00:00
abstract::The resting state default mode network (DMN) has been shown to characterize a number of neurological and psychiatric disorders. Evidence suggests an underlying genetic basis for this network and hence could serve as potential endophenotype for these disorders. Heritability is a defining criterion for endophenotypes. T...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22446
更新日期:2014-08-01 00:00:00