Abstract:
:Although elevated serum high-sensitivity C-reactive protein (hsCRP) is related to atherosclerosis, brain infarction, and cognitive decline, it has not been clarified whether increased hsCRP is associated with the decline in brain gray matter volume. Therefore, the purpose of this study was to determine the relationship between hsCRP levels and brain regional gray matter volume using brain magnetic resonance imaging (MRI) data from 109 community-dwelling healthy elderly subjects. Brain MRIs were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra (DARTEL) procedure. We found a significant negative correlation between regional gray matter volume of the posterior and lateral aspects of the left temporal cortex and hsCRP level after adjusting for age, gender, and intracranial volume. Our results suggest that subjects who have mild inflammation related to arteriosclerosis have decreased regional gray matter volume in the posterior and lateral aspects of the left temporal cortex. Thus, preventing the progression of arteriosclerosis may be important for preventing a decrease in gray matter volume in healthy elderly subjects.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Taki Y,Thyreau B,Kinomura S,Sato K,Goto R,Wu K,Kakizaki M,Tsuji I,Kawashima R,Fukuda Hdoi
10.1002/hbm.22073subject
Has Abstractpub_date
2013-10-01 00:00:00pages
2418-24issue
10eissn
1065-9471issn
1097-0193journal_volume
34pub_type
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journal_title:Human brain mapping
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doi:10.1002/hbm.21032
更新日期:2011-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:
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