Detectability of cerebellar activity with magnetoencephalography and electroencephalography.

Abstract:

:Electrophysiological signals from the cerebellum have traditionally been viewed as inaccessible to magnetoencephalography (MEG) and electroencephalography (EEG). Here, we challenge this position by investigating the ability of MEG and EEG to detect cerebellar activity using a model that employs a high-resolution tessellation of the cerebellar cortex. The tessellation was constructed from repetitive high-field (9.4T) structural magnetic resonance imaging (MRI) of an ex vivo human cerebellum. A boundary-element forward model was then used to simulate the M/EEG signals resulting from neural activity in the cerebellar cortex. Despite significant signal cancelation due to the highly convoluted cerebellar cortex, we found that the cerebellar signal was on average only 30-60% weaker than the cortical signal. We also made detailed M/EEG sensitivity maps and found that MEG and EEG have highly complementary sensitivity distributions over the cerebellar cortex. Based on previous fMRI studies combined with our M/EEG sensitivity maps, we discuss experimental paradigms that are likely to offer high M/EEG sensitivity to cerebellar activity. Taken together, these results show that cerebellar activity should be clearly detectable by current M/EEG systems with an appropriate experimental setup.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Samuelsson JG,Sundaram P,Khan S,Sereno MI,Hämäläinen MS

doi

10.1002/hbm.24951

subject

Has Abstract

pub_date

2020-06-15 00:00:00

pages

2357-2372

issue

9

eissn

1065-9471

issn

1097-0193

journal_volume

41

pub_type

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