Pramipexole modulates the neural network of reward anticipation.

Abstract:

:Pramipexole is widely prescribed to treat Parkinson's disease. It has been found to cause impulse control disorders such as pathological gambling. To examine how pramipexole modulates the network of reward anticipation, we carried out a pharmacological functional magnetic resonance imaging study with a double-blind, within-subject design. During the anticipation of monetary rewards, pramipexole increased the activity of the nucleus accumbens (NAcc), enhanced the interaction between the NAcc and the anterior insula, but weakened the interaction between the NAcc and the prefrontal cortex. These results suggest that pramipexole may exaggerate incentive and affective responses to possible rewards, but reduce the top-down control of impulses, leading to an increase in impulsive behaviors. This imbalance between the prefrontal-striatum connectivity and the insula-striatum connectivity may represent the neural mechanism of pathological gambling caused by pramipexole.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Ye Z,Hammer A,Camara E,Münte TF

doi

10.1002/hbm.21067

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

800-11

issue

5

eissn

1065-9471

issn

1097-0193

journal_volume

32

pub_type

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