Voxelwise and skeleton-based region of interest analysis of fetal alcohol syndrome and fetal alcohol spectrum disorders in young adults.

Abstract:

:Though fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders are among the most common developmental disorders, their understanding is incomplete. Diffusion tensor imaging (DTI), which is sensitive to microstructural organization in white matter, may provide a relevant measure in this population demonstrating incompletely characterized white matter pathology. In this study, tract-based spatial statistics (TBSS) routine and a skeleton-based region of interest analyses were employed to detect differences in DTI-derived metrics between young adults who were alcohol exposed and an unexposed control group. Participants include 28 with dysmorphic features associated with FAS, 29 who were prenatally exposed but do not show physical effects, and 25 with the same low socioeconomic status but unexposed. The TBSS analysis revealed a statistically significant decrease in fractional anisotropy at the isthmus of the corpus callosum and its connected callosal fibers in dysmorphic individuals relative to controls (clusterwise P(FWE) < 0.05). This finding was consistent with that of the follow-up skeleton-based region of interest analysis (F((2,79)) = 3.256, p = 0.044). In addition, the patterns in axial and radial diffusivity changes suggest that demyelination may be associated with the degraded white matter integrity observed in the dysmorphic group.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Li L,Coles CD,Lynch ME,Hu X

doi

10.1002/hbm.20747

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

3265-74

issue

10

eissn

1065-9471

issn

1097-0193

journal_volume

30

pub_type

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