Segmentation of skull and scalp in 3-D human MRI using mathematical morphology.

Abstract:

:We present a new technique for segmentation of skull and scalp in T(1)-weighted magnetic resonance images (MRIs) of the human head. Our method uses mathematical morphological operations to generate realistic models of the skull, scalp, and brain that are suitable for electroencephalography (EEG) and magnetoencephalography (MEG) source modeling. We first segment the brain using our Brain Surface Extractor algorithm; using this, we can ensure that the brain does not intersect our skull segmentation. We next generate a scalp mask using a combination of thresholding and mathematical morphology. We use the scalp mask in our skull segmentation procedure, as it allows us to automatically exclude background voxels with intensities similar to those of the skull. We find the inner and outer skull boundaries using thresholding and morphological operations. Finally, we mask the results with the scalp and brain volumes to ensure closed and nonintersecting skull boundaries. Visual evaluation indicated accurate segmentations of the cranium at a gross anatomical level (other than small holes in the zygomatic bone in eight subjects) in all 44 MRI volumes processed when run using default settings. In a quantitative comparison with coregistered CT images as a gold standard, MRI skull segmentation accuracy, as measured using the Dice coefficient, was found to be similar to that which would be obtained using CT imagery with a registration error of 2-3 mm.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Dogdas B,Shattuck DW,Leahy RM

doi

10.1002/hbm.20159

keywords:

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

273-85

issue

4

eissn

1065-9471

issn

1097-0193

journal_volume

26

pub_type

杂志文章
  • Cross auditory-spatial learning in early-blind individuals.

    abstract::Cross-modal processing enables the utilization of information received via different sensory organs to facilitate more complicated human actions. We used functional MRI on early-blind individuals to study the neural processes associated with cross auditory-spatial learning. The auditory signals, converted from echoes ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21395

    authors: Chan CC,Wong AW,Ting KH,Whitfield-Gabrieli S,He J,Lee TM

    更新日期:2012-11-01 00:00:00

  • Losing the struggle to stay awake: divergent thalamic and cortical activity during microsleeps.

    abstract::Maintaining alertness is critical for safe and successful performance of most human activities. Consequently, microsleeps during continuous visuomotor tasks, such as driving, can be very serious, not only disrupting performance but sometimes leading to injury or death due to accidents. We have investigated the neural ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22178

    authors: Poudel GR,Innes CR,Bones PJ,Watts R,Jones RD

    更新日期:2014-01-01 00:00:00

  • The mirror neuron system and the strange case of Broca's area.

    abstract::Mirror neurons, originally described in the monkey premotor area F5, are embedded in a frontoparietal network for action execution and observation. A similar Mirror Neuron System (MNS) exists in humans, including precentral gyrus, inferior parietal lobule, and superior temporal sulcus. Controversial is the inclusion o...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22682

    authors: Cerri G,Cabinio M,Blasi V,Borroni P,Iadanza A,Fava E,Fornia L,Ferpozzi V,Riva M,Casarotti A,Martinelli Boneschi F,Falini A,Bello L

    更新日期:2015-03-01 00:00:00

  • Understanding the association between psychomotor processing speed and white matter hyperintensity: A comprehensive multi-modality MR imaging study.

    abstract::Cognitive processing speed is crucial for human cognition and declines with aging. White matter hyperintensity (WMH), a common sign of WM vascular damage in the elderly, is closely related to slower psychomotor processing speed. In this study, we investigated the association between WMH and psychomotor speed changes t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24826

    authors: Wang S,Jiaerken Y,Yu X,Shen Z,Luo X,Hong H,Sun J,Xu X,Zhang R,Zhou Y,Lou M,Huang P,Zhang M

    更新日期:2020-02-15 00:00:00

  • Unsupervised clustering of dopamine transporter PET imaging discovers heterogeneity of parkinsonism.

    abstract::Parkinsonism has heterogeneous nature, showing distinctive patterns of disease progression and prognosis. We aimed to find clusters of parkinsonism based on 18 F-fluoropropyl-carbomethoxyiodophenylnortropane (FP-CIT) PET as a data-driven approach to evaluate heterogenous dopaminergic neurodegeneration patterns. Two di...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25155

    authors: Suh M,Im JH,Choi H,Kim HJ,Cheon GJ,Jeon B

    更新日期:2020-11-01 00:00:00

  • Material specific lateralization of medial temporal lobe function: An fMRI investigation.

    abstract::The theory of material specific lateralization of memory function posits that left and right MTL regions are asymmetrically involved in mnemonic processing of verbal and nonverbal material respectively. Lesion and functional imaging (fMRI) studies provide robust evidence for a left MTL asymmetry in the verbal memory d...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23077

    authors: Dalton MA,Hornberger M,Piguet O

    更新日期:2016-03-01 00:00:00

  • Default-mode network dynamics are restricted during high speed discrimination in healthy aging: Associations with neurocognitive status and simulated driving behavior.

    abstract::Numerous daily tasks, including car driving, require fine visuospatial tuning. One such visuospatial ability, speed discrimination, declines with aging but its neural underpinnings remain unknown. In this study, we use fMRI to explore the effect of aging during a high speed discrimination task and its neural underpinn...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24240

    authors: Eudave L,Martínez M,Luis EO,Pastor MA

    更新日期:2018-11-01 00:00:00

  • Abnormal neural response to phonological working memory demands in persistent developmental stuttering.

    abstract::Persistent developmental stuttering is a neurological disorder that commonly manifests as a motor problem. Cognitive theories, however, hold that poorly developed cognitive skills are the origins of stuttering. Working memory (WM), a multicomponent cognitive system that mediates information maintenance and manipulatio...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24366

    authors: Yang Y,Jia F,Fox PT,Siok WT,Tan LH

    更新日期:2019-01-01 00:00:00

  • Statistical inference in brain graphs using threshold-free network-based statistics.

    abstract::The description of brain networks as graphs where nodes represent different brain regions and edges represent a measure of connectivity between a pair of nodes is an increasingly used approach in neuroimaging research. The development of powerful methods for edge-wise group-level statistical inference in brain graphs ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24007

    authors: Baggio HC,Abos A,Segura B,Campabadal A,Garcia-Diaz A,Uribe C,Compta Y,Marti MJ,Valldeoriola F,Junque C

    更新日期:2018-06-01 00:00:00

  • Alterations in intrinsic fronto-thalamo-parietal connectivity are associated with cognitive control deficits in psychotic disorders.

    abstract::Despite a growing number of reports about alterations in intrinsic/resting brain activity observed in patients with psychotic disorders, their relevance to well-established cognitive control deficits in this patient group is not well understood. Totally 88 clinically stabilized patients with a psychotic disorder and 5...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24362

    authors: Lencer R,Yao L,Reilly JL,Keedy SK,McDowell JE,Keshavan MS,Pearlson GD,Tamminga CA,Gershon ES,Clementz BA,Lui S,Sweeney JA

    更新日期:2019-01-01 00:00:00

  • Neural basis for sentence comprehension: grammatical and short-term memory components.

    abstract::We monitored regional cerebral activity with BOLD fMRI while subjects were presented written sentences differing in their grammatical structure (subject-relative or object-relative center-embedded clauses) and their short-term memory demands (short or long antecedent-gap linkages). A core region of left posterior supe...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.10006

    authors: Cooke A,Zurif EB,DeVita C,Alsop D,Koenig P,Detre J,Gee J,Pinãngo M,Balogh J,Grossman M

    更新日期:2002-02-01 00:00:00

  • A brain-wide association study of DISC1 genetic variants reveals a relationship with the structure and functional connectivity of the precuneus in schizophrenia.

    abstract::The Disrupted in Schizophrenia Gene 1 (DISC1) plays a role in both neural signaling and development and is associated with schizophrenia, although its links to altered brain structure and function in this disorder are not fully established. Here we have used structural and functional MRI to investigate links with six ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22560

    authors: Gong X,Lu W,Kendrick KM,Pu W,Wang C,Jin L,Lu G,Liu Z,Liu H,Feng J

    更新日期:2014-11-01 00:00:00

  • Functional interactions between oculomotor regions during prosaccades and antisaccades.

    abstract::Human behavior reflects a continual negotiation of automatic and directed actions. The oculomotor network is a well-characterized neural system in which to study this balance of behavioral control. For instance, saccades made toward and away from a flashed visual stimulus (prosaccades and antisaccades, respectively) a...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20146

    authors: Miller LM,Sun FT,Curtis CE,D'Esposito M

    更新日期:2005-10-01 00:00:00

  • From hippocampus to whole-brain: The role of integrative processing in episodic memory retrieval.

    abstract::Multivariate functional connectivity analyses of neuroimaging data have revealed the importance of complex, distributed interactions between disparate yet interdependent brain regions. Recent work has shown that topological properties of functional brain networks are associated with individual and group differences in...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23518

    authors: Geib BR,Stanley ML,Dennis NA,Woldorff MG,Cabeza R

    更新日期:2017-04-01 00:00:00

  • Effects of change in FreeSurfer version on classification accuracy of patients with Alzheimer's disease and mild cognitive impairment.

    abstract::Studies have found non-negligible differences in cortical thickness estimates across versions of software that are used for processing and quantifying MRI-based cortical measurements, and issues have arisen regarding these differences, as obtained estimates could potentially affect the validity of the results. However...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23139

    authors: Chepkoech JL,Walhovd KB,Grydeland H,Fjell AM,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2016-05-01 00:00:00

  • A novel method for integrating MEG and BOLD fMRI signals with the linear convolution model in human primary somatosensory cortex.

    abstract::Characterizing the neurovascular coupling between hemodynamic signals and their neural origins is crucial to functional neuroimaging research, even more so as new methods become available for integrating results from different functional neuroimaging modalities. We present a novel method to relate magnetoencephalograp...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20361

    authors: Nangini C,Tam F,Graham SJ

    更新日期:2008-01-01 00:00:00

  • Brain systems involved in arithmetic with positive versus negative numbers.

    abstract::Positive number arithmetic is based on combining and separating sets of items, with systematic differences in brain activity in specific regions depending on operation. In contrast, arithmetic with negative numbers involves manipulating abstract values worth less than zero, possibly involving different operation-activ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22201

    authors: Gullick MM,Wolford G

    更新日期:2014-02-01 00:00:00

  • Development of hippocampal subfield volumes from 4 to 22 years.

    abstract::The hippocampus supports several important cognitive functions known to undergo substantial development during childhood and adolescence, for example, encoding and consolidation of vivid personal memories. However, diverging developmental effects on hippocampal volume have been observed across studies. It is possible ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22576

    authors: Krogsrud SK,Tamnes CK,Fjell AM,Amlien I,Grydeland H,Sulutvedt U,Due-Tønnessen P,Bjørnerud A,Sølsnes AE,Håberg AK,Skrane J,Walhovd KB

    更新日期:2014-11-01 00:00:00

  • Greater leftward lateralization of the inferior frontal gyrus in second language learners with higher syntactic abilities.

    abstract::There is a great individual variability for acquiring syntactic knowledge in a second language (L2). Little is, however, known if there is any anatomical basis in the brain for individual differences in syntactic acquisition. Here we examined brain structures in 95 nonnative speakers of English, including 78 high-scho...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20790

    authors: Nauchi A,Sakai KL

    更新日期:2009-11-01 00:00:00

  • Relationship between structural and functional connectivity change across the adult lifespan: A longitudinal investigation.

    abstract::Extensive efforts are devoted to understand the functional (FC) and structural connections (SC) of the brain. FC is usually measured by functional magnetic resonance imaging (fMRI), and conceptualized as degree of synchronicity in brain activity between different regions. SC is typically indexed by measures of white m...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23403

    authors: Fjell AM,Sneve MH,Grydeland H,Storsve AB,Amlien IK,Yendiki A,Walhovd KB

    更新日期:2017-01-01 00:00:00

  • Early red nucleus atrophy in relapse-onset multiple sclerosis.

    abstract::No study has investigated red nucleus (RN) atrophy in multiple sclerosis (MS) despite cerebellum and its connections are elective sites of MS-related pathology. In this study, we explore RN atrophy in early MS phases and its association with cerebellar damage (focal lesions and atrophy) and physical disability. Thirty...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25213

    authors: Margoni M,Poggiali D,Zywicki S,Rubin M,Lazzarotto A,Franciotta S,Anglani MG,Causin F,Rinaldi F,Perini P,Filippi M,Gallo P

    更新日期:2021-01-01 00:00:00

  • Neural response to stress and perceived stress differ in patients with left temporal lobe epilepsy.

    abstract::Patients with epilepsy are often able to predict seizure occurrence subsequent to an acute stress experience. However, neuroimaging investigations into the neural basis of this relationship or the potential influence of perceived life stress are limited. The current study assessed the relationship between perceived st...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24606

    authors: Goodman AM,Allendorfer JB,Heyse H,Szaflarski BA,Eliassen JC,Nelson EB,Storrs JM,Szaflarski JP

    更新日期:2019-08-15 00:00:00

  • The effect of ageing on fMRI: Correction for the confounding effects of vascular reactivity evaluated by joint fMRI and MEG in 335 adults.

    abstract::In functional magnetic resonance imaging (fMRI) research one is typically interested in neural activity. However, the blood-oxygenation level-dependent (BOLD) signal is a composite of both neural and vascular activity. As factors such as age or medication may alter vascular function, it is essential to account for cha...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22768

    authors: Tsvetanov KA,Henson RN,Tyler LK,Davis SW,Shafto MA,Taylor JR,Williams N,Cam-Can,Rowe JB

    更新日期:2015-06-01 00:00:00

  • Group analysis and the subject factor in functional magnetic resonance imaging: analysis of fifty right-handed healthy subjects in a semantic language task.

    abstract::Before considering a given fMRI paradigm as a valid clinical tool, one should first assess the reliability of functional responses across subjects by establishing a normative database and defining a reference activation map that identifies major brain regions involved in the task at hand. However, the definition of su...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20410

    authors: Seghier ML,Lazeyras F,Pegna AJ,Annoni JM,Khateb A

    更新日期:2008-04-01 00:00:00

  • Converging function, structure, and behavioural features of emotion regulation in very preterm children.

    abstract::Children born very preterm (VPT; <32 weeks' gestational age) are at high risk for emotional regulation and social communication impairments. However, the underlying neurobiological correlates of these difficulties remain poorly understood. Using a multimodal approach, including both magnetoencephalographic and structu...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24604

    authors: Urbain C,Sato J,Hammill C,Duerden EG,Taylor MJ

    更新日期:2019-08-01 00:00:00

  • Mapping reliability in multicenter MRI: voxel-based morphometry and cortical thickness.

    abstract::Multicenter structural MRI studies can have greater statistical power than single-center studies. However, across-center differences in contrast sensitivity, spatial uniformity, etc., may lead to tissue classification or image registration differences that could reduce or wholly offset the enhanced statistical power o...

    journal_title:Human brain mapping

    pub_type: 杂志文章,多中心研究

    doi:10.1002/hbm.20991

    authors: Schnack HG,van Haren NE,Brouwer RM,van Baal GC,Picchioni M,Weisbrod M,Sauer H,Cannon TD,Huttunen M,Lepage C,Collins DL,Evans A,Murray RM,Kahn RS,Hulshoff Pol HE

    更新日期:2010-12-01 00:00:00

  • Taking tests in the magnet: Brain mapping standardized tests.

    abstract::Standardized psychometric tests are sophisticated, well-developed, and consequential instruments; test outcomes are taken as facts about people that impact their lives in important ways. As part of an initial demonstration that human brain mapping techniques can add converging neural-level evidence to understanding st...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23761

    authors: Rubin DC,Li D,Hall SA,Kragel PA,Berntsen D

    更新日期:2017-11-01 00:00:00

  • Neural signature of inattentional deafness.

    abstract::Inattentional deafness is the failure to hear otherwise audible sounds (usually alarms) that may occur under high workload conditions. One potential cause for its occurrence could be an attentional bottleneck that occurs when task demands are high, resulting in lack of resources for processing of additional tasks. In ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23735

    authors: Durantin G,Dehais F,Gonthier N,Terzibas C,Callan DE

    更新日期:2017-11-01 00:00:00

  • Somatosensory system in two types of motor reorganization in congenital hemiparesis: topography and function.

    abstract::This study investigates the (re-)organization of somatosensory functions following early brain lesions. Using functional magnetic resonance imaging (fMRI), passive hand movement was studied. Transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG) were used as complementary methods. fMRI data was analy...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20545

    authors: Wilke M,Staudt M,Juenger H,Grodd W,Braun C,Krägeloh-Mann I

    更新日期:2009-03-01 00:00:00

  • Structural brain correlates of cognitive and behavioral impairment in MND.

    abstract:OBJECTIVE:To assess the structural correlates of cognitive and behavioral impairment in motor neuron diseases (MND) using multimodal MRI. METHODS:One hundred one patients with sporadic MND (56 classic amyotrophic lateral sclerosis, 31 upper motor neuron phenotype, and 14 lower motor neuron phenotype) and 51 controls w...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23124

    authors: Agosta F,Ferraro PM,Riva N,Spinelli EG,Chiò A,Canu E,Valsasina P,Lunetta C,Iannaccone S,Copetti M,Prudente E,Comi G,Falini A,Filippi M

    更新日期:2016-04-01 00:00:00