Development of hippocampal subfield volumes from 4 to 22 years.

Abstract:

:The hippocampus supports several important cognitive functions known to undergo substantial development during childhood and adolescence, for example, encoding and consolidation of vivid personal memories. However, diverging developmental effects on hippocampal volume have been observed across studies. It is possible that the inconsistent findings may attribute to varying developmental processes and functions related to different hippocampal subregions. Most studies to date have measured global hippocampal volume. We aimed to explore early hippocampal development both globally and regionally within subfields. Using cross-sectional 1.5 T magnetic resonance imaging data from 244 healthy participants aged 4-22 years, we performed automated hippocampal segmentation of seven subfield volumes; cornu ammonis (CA) 1, CA2/3, CA4/dentate gyrus (DG), presubiculum, subiculum, fimbria, and hippocampal fissure. For validation purposes, seven subjects were scanned at both 1.5 and 3 T, and all subfields except fimbria showed strong correlations across field strengths. Effects of age, left and right hemisphere, sex and their interactions were explored. Nonparametric local smoothing models (smoothing spline) were used to depict age-trajectories. Results suggested nonlinear age functions for most subfields where volume increases until 13-15 years, followed by little age-related changes during adolescence. Further, the results showed greater right than left hippocampal volumes that seemed to be augmenting in older age. Sex differences were also found for subfields; CA2/3, CA4/DG, presubiculum, subiculum, and CA1, mainly driven by participants under 13 years. These results provide a detailed characterization of hippocampal subfield development from early childhood.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Krogsrud SK,Tamnes CK,Fjell AM,Amlien I,Grydeland H,Sulutvedt U,Due-Tønnessen P,Bjørnerud A,Sølsnes AE,Håberg AK,Skrane J,Walhovd KB

doi

10.1002/hbm.22576

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

5646-57

issue

11

eissn

1065-9471

issn

1097-0193

journal_volume

35

pub_type

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