Abstract:
:Dysfunction of corticostriatal loops has been proposed to underlie certain cognitive and behavioral problems associated with various neuropsychiatric disorders, such as obsessive-compulsive disorder (OCD) characterized by repetitive, unwanted thoughts, and behaviors. Although functional abnormalities in the loops involving the orbitofronto-striato-thalamic (OFST) circuitry in patients with OCD have been reported, our understanding of a link between disruptions in the architecture of the intrinsic functional network of the OFST circuit and their symptoms remain incomplete. Using resting-state functional MRI in conjunction with unsupervised clustering and multilevel functional connectivity (FC) techniques, FC of the OFST network and its topological organization in 61 OCD patients versus 61 matched controls were characterized. Patients exhibited disruptions in small-world properties of the OFST circuit, which indicates an imbalance between functional integration and segregation. Patients also showed decreased FC between the central orbitofrontal cortex and dorsomedial striatum but increased FC between the medial thalamus and striatal areas. Using one of the largest samples of unmedicated OCD patients to date, our findings provide evidence supporting the OFST dysconnection hypothesis in OCD as a basic pathophysiological mechanism underlying the disorder, showing the disruption of FC between specific cortical, striatal, and thalamic clusters and aberrant topological patterns of the OFST circuit. Hum Brain Mapp 38:109-119, 2017. © 2016 Wiley Periodicals, Inc.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Jung WH,Yücel M,Yun JY,Yoon YB,Cho KI,Parkes L,Kim SN,Kwon JSdoi
10.1002/hbm.23347subject
Has Abstractpub_date
2017-01-01 00:00:00pages
109-119issue
1eissn
1065-9471issn
1097-0193journal_volume
38pub_type
杂志文章abstract::Cortical hubs play a fundamental role in the functional architecture of brain connectivity at rest. However, the anatomical scaffold underlying their centrality is still under debate. Certainly, the brain function and anatomy are significantly entwined through synaptogenesis and pruning mechanisms that continuously re...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23721
更新日期:2017-10-01 00:00:00
abstract::During complex tasks, patterns of functional connectivity differ from those in the resting state. However, what accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous and task-evoked activities. The difference in functional connectivity between a task sta...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24335
更新日期:2018-12-01 00:00:00
abstract::Conflict monitoring and motor inhibition are engaged in the performance of complex tasks. The midcingulate cortex (MCC) has been suggested to detect conflicts, whereas the right inferior frontal cortex (IFC) seems to be of relevance for the inhibition process. The current experiment investigates the neural underpinnin...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22002
更新日期:2013-07-01 00:00:00
abstract::Action observation leads to the automatic activation of the corresponding motor representation in the observer through "mirror-matching." This constitutes a "shared representational system," which is thought to subserve social understanding by motor simulation. However, it is unclear how these shared representations c...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20800
更新日期:2009-11-01 00:00:00
abstract::Simultaneous electroencephalography and functional magnetic resonance imaging (EEG/fMRI) have been proposed to contribute to the definition of the epileptic seizure onset zone. Following interictal epileptiform discharges, one usually assumes a canonical hemodynamic response function (HRF), which has been derived from...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20925
更新日期:2010-08-01 00:00:00
abstract::We previously showed that dual-task cost (DTC) on gait speed in people with Parkinson's disease (PD) improved after 6 weeks of the Agility Boot Camp with Cognitive Challenge (ABC-C) exercise program. Since deficits in dual-task gait speed are associated with freezing of gait and gray matter atrophy, here we performed ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25211
更新日期:2021-01-01 00:00:00
abstract::The willingness to incur personal costs to enforce prosocial norms represents a hallmark of human civilization. Although recent neuroscience studies have used the ultimatum game to understand the neuropsychological mechanisms that underlie the enforcement of fairness norms; however, a precise characterization of the n...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.22649
更新日期:2015-02-01 00:00:00
abstract::Maintaining alertness is critical for safe and successful performance of most human activities. Consequently, microsleeps during continuous visuomotor tasks, such as driving, can be very serious, not only disrupting performance but sometimes leading to injury or death due to accidents. We have investigated the neural ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22178
更新日期:2014-01-01 00:00:00
abstract::Whereas resting state blood oxygenation-level dependent (BOLD) functional MRI has been widely used to assess functional connectivity between cortical regions, the laminar specificity of such measures is poorly understood. This study aims to determine: (a) whether the resting state functional connectivity (rsFC) betwee...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24375
更新日期:2019-01-01 00:00:00
abstract::Cognitive processing speed is crucial for human cognition and declines with aging. White matter hyperintensity (WMH), a common sign of WM vascular damage in the elderly, is closely related to slower psychomotor processing speed. In this study, we investigated the association between WMH and psychomotor speed changes t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24826
更新日期:2020-02-15 00:00:00
abstract::Previous studies have led to the proposal that patients with Alzheimer's disease (AD) may have disturbed functional connectivity between different brain regions. Furthermore, recent resting-state functional magnetic resonance imaging (fMRI) studies have also shown that low-frequency (<0.08 Hz) fluctuations (LFF) of th...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20324
更新日期:2007-10-01 00:00:00
abstract::We systematically investigated the effects of cathodal and anodal Transcranial Direct Current Stimulation (CtDCS, AtDCS) on the electric activity of primary motor cortex during a motor task. High-density electroencephalography was used to define the spatial diffusion of tDCS after effects. Ten healthy subjects perform...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22322
更新日期:2014-05-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder with dysfunction in cortices as well as white matter (WM) tracts. While the changes to WM structure have been extensively investigated in PD, the nature of the functional changes to WM remains unknown. In this study, the regional activity and functional connecti...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24444
更新日期:2019-03-01 00:00:00
abstract::There are an increasing number of neuroimaging studies that allow a better understanding of symptoms, neural correlates and associated conditions of fibromyalgia. However, the results of these studies are difficult to compare, as they include a heterogeneous group of patients, use different stimulation paradigms, task...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.23132
更新日期:2016-05-01 00:00:00
abstract::The extent of central nervous system involvement in Kennedy's disease (KD) relative to other motor neuron disease (MND) phenotypes still needs to be clarified. In this study, we investigated cortical and white matter (WM) MRI alterations in 25 patients with KD, compared with 24 healthy subjects, 25 patients with spora...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24583
更新日期:2019-07-01 00:00:00
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journal_title:Human brain mapping
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/hbm.1049
更新日期:2001-11-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23580
更新日期:2017-06-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20537
更新日期:2008-07-01 00:00:00
abstract::The orienting of attention to the spatial location of sensory stimuli in one modality based on sensory stimuli presented in another modality (i.e., cross-modal orienting) is a common mechanism for controlling attentional shifts. The neuronal mechanisms of top-down cross-modal orienting have been studied extensively. H...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22227
更新日期:2014-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21119
更新日期:2011-09-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::The TREK1 gene has been linked to a depression-resistant phenotype in rodents and antidepressant response in humans, but the neural mechanisms underlying these links are unclear. Because TREK1 is expressed in reward-related basal ganglia regions, it has been hypothesized that TREK1 genetic variation may be associated ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20858
更新日期:2010-02-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21511
更新日期:2013-06-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22865
更新日期:2015-09-01 00:00:00
abstract::The Stroop interference test requires a person to respond to specific elements of a stimulus while suppressing a competing response. Previous positron emission tomography (PET) work has shown increased activity in the right anterior cingulate gyrus during the Stroop test. It is unclear, however, whether the anterior c...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.460010305
更新日期:1994-01-01 00:00:00
abstract::Perinatal stroke is the leading cause of hemiparetic cerebral palsy (CP), resulting in life-long disability. In this study, we examined the relationship between robotic upper extremity motor impairment and corticospinal tract (CST) diffusion properties. Thirty-three children with unilateral perinatal ischemic stroke (...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23904
更新日期:2018-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.25029
更新日期:2020-05-18 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(1999)7:2<136::aid-hbm6>3.0
更新日期:1999-01-01 00:00:00
abstract::The present fMRI study used a spelling task to investigate the hypothesis that the left ventral occipitotemporal cortex (vOT) hosts neuronal representations of whole written words. Such an orthographic word lexicon is posited by cognitive dual-route theories of reading and spelling. In the scanner, participants perfor...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22709
更新日期:2015-04-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00