Regional and network properties of white matter function in Parkinson's disease.

Abstract:

:Parkinson's disease (PD) is a neurodegenerative disorder with dysfunction in cortices as well as white matter (WM) tracts. While the changes to WM structure have been extensively investigated in PD, the nature of the functional changes to WM remains unknown. In this study, the regional activity and functional connectivity of WM were compared between PD patients (n = 57) and matched healthy controls (n = 52), based on multimodel magnetic resonance imaging data sets. By tract-based spatial statistical analyses of regional activity, patients showed decreased structural-functional coupling in the left corticospinal tract compared to controls. This tract also displayed abnormally increased functional connectivity within the left post-central gyrus and left putamen in PD patients. At the network level, the WM functional network showed small-worldness in both controls and PD patients, yet it was abnormally increased in the latter group. Based on the features of the WM functional connectome, previously un-evaluated individuals could be classified with fair accuracy (73%) and area under the curve of the receiver operating characteristics (75%). These neuroimaging findings provide direct evidence for WM functional changes in PD, which is crucial to understand the functional role of fiber tracts in the pathology of neural circuits.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Ji GJ,Ren C,Li Y,Sun J,Liu T,Gao Y,Xue D,Shen L,Cheng W,Zhu C,Tian Y,Hu P,Chen X,Wang K

doi

10.1002/hbm.24444

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

1253-1263

issue

4

eissn

1065-9471

issn

1097-0193

journal_volume

40

pub_type

杂志文章
  • A novel method for integrating MEG and BOLD fMRI signals with the linear convolution model in human primary somatosensory cortex.

    abstract::Characterizing the neurovascular coupling between hemodynamic signals and their neural origins is crucial to functional neuroimaging research, even more so as new methods become available for integrating results from different functional neuroimaging modalities. We present a novel method to relate magnetoencephalograp...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20361

    authors: Nangini C,Tam F,Graham SJ

    更新日期:2008-01-01 00:00:00

  • Altered interregional molecular associations of the serotonin transporter in attention deficit/hyperactivity disorder assessed with PET.

    abstract::Altered serotonergic neurotransmission has been found to cause impulsive and aggressive behavior, as well as increased motor activity, all exemplifying key symptoms of ADHD. The main objectives of this positron emission tomography (PET) study were to investigate the serotonin transporter binding potential (SERT BPND )...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23418

    authors: Vanicek T,Kutzelnigg A,Philippe C,Sigurdardottir HL,James GM,Hahn A,Kranz GS,Höflich A,Kautzky A,Traub-Weidinger T,Hacker M,Wadsak W,Mitterhauser M,Kasper S,Lanzenberger R

    更新日期:2017-02-01 00:00:00

  • White matter abnormalities associated with military PTSD in the context of blast TBI.

    abstract::Mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) are common among recent military veterans and involve substantial symptom overlap, making clinical distinction and effective intervention difficult. Emerging evidence of cerebral white matter abnormalities associated with mTBI may provide a b...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22685

    authors: Davenport ND,Lim KO,Sponheim SR

    更新日期:2015-03-01 00:00:00

  • A brain-wide association study of DISC1 genetic variants reveals a relationship with the structure and functional connectivity of the precuneus in schizophrenia.

    abstract::The Disrupted in Schizophrenia Gene 1 (DISC1) plays a role in both neural signaling and development and is associated with schizophrenia, although its links to altered brain structure and function in this disorder are not fully established. Here we have used structural and functional MRI to investigate links with six ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22560

    authors: Gong X,Lu W,Kendrick KM,Pu W,Wang C,Jin L,Lu G,Liu Z,Liu H,Feng J

    更新日期:2014-11-01 00:00:00

  • Exploring the unity and diversity of the neural substrates of executive functioning.

    abstract::Previous studies exploring the neural substrates of executive functioning used task-specific analyses, which might not be the most appropriate approach due to the difficulty of precisely isolating executive functions. Consequently, the aim of this study was to use positron emission tomography (PET) to reexamine by con...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20118

    authors: Collette F,Van der Linden M,Laureys S,Delfiore G,Degueldre C,Luxen A,Salmon E

    更新日期:2005-08-01 00:00:00

  • Negative BOLD responses to epileptic spikes.

    abstract::Simultaneous electroencephalogram/functional magnetic resonance imaging (EEG-fMRI) during interictal epileptiform discharges can result in positive (activation) and negative (deactivation) changes in the blood oxygenation level-dependent (BOLD) signal. Activation probably reflects increased neuronal activity and energ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20193

    authors: Kobayashi E,Bagshaw AP,Grova C,Dubeau F,Gotman J

    更新日期:2006-06-01 00:00:00

  • Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence.

    abstract:BACKGROUND:Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project. MET...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21446

    authors: Schilling C,Kühn S,Romanowski A,Banaschewski T,Barbot A,Barker GJ,Brühl R,Büchel C,Charlet K,Conrod PJ,Czech K,Dalley JW,Flor H,Häke I,Ittermann B,Ivanov N,Mann K,Lüdemann K,Martinot JL,Palafox C,Paus T,Poline J

    更新日期:2013-02-01 00:00:00

  • Reduced striato-cortical and inhibitory transcallosal connectivity in the motor circuit of Huntington's disease patients.

    abstract::Huntington's disease (HD) is a neurodegenerative disorder which is primarily associated with striatal degeneration. However, the alterations in connectivity of this structure in HD have been underinvestigated. In this study, we analyzed the functional and structural connectivity of the left putamen, while participants...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23813

    authors: Garcia-Gorro C,de Diego-Balaguer R,Martínez-Horta S,Pérez-Pérez J,Kulisevsky J,Rodríguez-Dechicha N,Vaquer I,Subira S,Calopa M,Muñoz E,Santacruz P,Ruiz-Idiago J,Mareca C,Caballol N,Camara E

    更新日期:2018-01-01 00:00:00

  • Robust Bayesian estimation of the hemodynamic response function in event-related BOLD fMRI using basic physiological information.

    abstract::In BOLD fMRI data analysis, robust and accurate estimation of the Hemodynamic Response Function (HRF) is still under investigation. Parametric methods assume the shape of the HRF to be known and constant throughout the brain, whereas non-parametric methods mostly rely on artificially increasing the signal-to-noise rat...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.10100

    authors: Marrelec G,Benali H,Ciuciu P,Pélégrini-Issac M,Poline JB

    更新日期:2003-05-01 00:00:00

  • Understanding the association between psychomotor processing speed and white matter hyperintensity: A comprehensive multi-modality MR imaging study.

    abstract::Cognitive processing speed is crucial for human cognition and declines with aging. White matter hyperintensity (WMH), a common sign of WM vascular damage in the elderly, is closely related to slower psychomotor processing speed. In this study, we investigated the association between WMH and psychomotor speed changes t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24826

    authors: Wang S,Jiaerken Y,Yu X,Shen Z,Luo X,Hong H,Sun J,Xu X,Zhang R,Zhou Y,Lou M,Huang P,Zhang M

    更新日期:2020-02-15 00:00:00

  • Neural activations at the junction of the inferior frontal sulcus and the inferior precentral sulcus: interindividual variability, reliability, and association with sulcal morphology.

    abstract::The sulcal morphology of the human frontal lobe is highly variable. Although the structural images usually acquired in functional magnetic resonance imaging studies provide information about this interindividual variability, this information is only rarely used to relate structure and function. Here, we investigated t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20501

    authors: Derrfuss J,Brass M,von Cramon DY,Lohmann G,Amunts K

    更新日期:2009-01-01 00:00:00

  • Matching is not naming: a direct comparison of lexical manipulations in explicit and implicit reading tasks.

    abstract::The neurobiological basis of reading is of considerable interest, yet analyzing data from subjects reading words aloud during functional MRI data collection can be difficult. Therefore, many investigators use surrogate tasks such as visual matching or rhyme matching to eliminate the need for spoken output. Use of thes...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22077

    authors: Vogel AC,Petersen SE,Schlaggar BL

    更新日期:2013-10-01 00:00:00

  • Pramipexole modulates the neural network of reward anticipation.

    abstract::Pramipexole is widely prescribed to treat Parkinson's disease. It has been found to cause impulse control disorders such as pathological gambling. To examine how pramipexole modulates the network of reward anticipation, we carried out a pharmacological functional magnetic resonance imaging study with a double-blind, w...

    journal_title:Human brain mapping

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/hbm.21067

    authors: Ye Z,Hammer A,Camara E,Münte TF

    更新日期:2011-05-01 00:00:00

  • Sub-hubs of baseline functional brain networks are related to early improvement following two-week pharmacological therapy for major depressive disorder.

    abstract::Accumulating evidence suggests that early improvement after two-week antidepressant treatment is predictive of later outcomes of patients with major depressive disorder (MDD); however, whether this early improvement is associated with baseline neural architecture remains largely unknown. Utilizing resting-state functi...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22817

    authors: Shen Y,Yao J,Jiang X,Zhang L,Xu L,Feng R,Cai L,Liu J,Wang J,Chen W

    更新日期:2015-08-01 00:00:00

  • From simultaneous to synergistic MR-PET brain imaging: A review of hybrid MR-PET imaging methodologies.

    abstract::Simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) scanning is a recent major development in biomedical imaging. The full integration of the PET detector ring and electronics within the MR system has been a technologically challenging design to develop but provides capacity for simult...

    journal_title:Human brain mapping

    pub_type: 杂志文章,评审

    doi:10.1002/hbm.24314

    authors: Chen Z,Jamadar SD,Li S,Sforazzini F,Baran J,Ferris N,Shah NJ,Egan GF

    更新日期:2018-12-01 00:00:00

  • Primary and multisensory cortical activity is correlated with audiovisual percepts.

    abstract::Incongruent auditory and visual stimuli can elicit audiovisual illusions such as the McGurk effect where visual /ka/ and auditory /pa/ fuse into another percept such as/ta/. In the present study, human brain activity was measured with adaptation functional magnetic resonance imaging to investigate which brain areas su...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20884

    authors: Benoit MM,Raij T,Lin FH,Jääskeläinen IP,Stufflebeam S

    更新日期:2010-04-01 00:00:00

  • The right inhibition? Callosal correlates of hand performance in healthy children and adolescents callosal correlates of hand performance.

    abstract::Numerous studies suggest that interhemispheric inhibition-relayed via the corpus callosum-plays an important role in unilateral hand motions. Interestingly, transcallosal inhibition appears to be indicative of a strong laterality effect, where generally the dominant hemisphere exerts inhibition on the nondominant one....

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22060

    authors: Kurth F,Mayer EA,Toga AW,Thompson PM,Luders E

    更新日期:2013-09-01 00:00:00

  • Oxytocin facilitates the sensation of social stress.

    abstract::Essentially all social species experience social stress which can be a catalyst for detriments in mental and physical health. The neuropeptide oxytocin (OXT) has been shown to produce anxiolytic and antistress effects, thereby qualifying the OXT system as a promising drug target in the treatment of stress-related diso...

    journal_title:Human brain mapping

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/hbm.22508

    authors: Eckstein M,Scheele D,Weber K,Stoffel-Wagner B,Maier W,Hurlemann R

    更新日期:2014-09-01 00:00:00

  • Regional hippocampal vulnerability in early multiple sclerosis: Dynamic pathological spreading from dentate gyrus to CA1.

    abstract:BACKGROUND:Whether hippocampal subfields are differentially vulnerable at the earliest stages of multiple sclerosis (MS) and how this impacts memory performance is a current topic of debate. METHOD:We prospectively included 56 persons with clinically isolated syndrome (CIS) suggestive of MS in a 1-year longitudinal st...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23970

    authors: Planche V,Koubiyr I,Romero JE,Manjon JV,Coupé P,Deloire M,Dousset V,Brochet B,Ruet A,Tourdias T

    更新日期:2018-04-01 00:00:00

  • Top-down and bottom-up influences on the left ventral occipito-temporal cortex during visual word recognition: an analysis of effective connectivity.

    abstract::The functional role of the left ventral occipito-temporal cortex (vOT) in visual word processing has been studied extensively. A prominent observation is higher activation for unfamiliar but pronounceable letter strings compared to regular words in this region. Some functional accounts have interpreted this finding as...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22281

    authors: Schurz M,Kronbichler M,Crone J,Richlan F,Klackl J,Wimmer H

    更新日期:2014-04-01 00:00:00

  • Performing label-fusion-based segmentation using multiple automatically generated templates.

    abstract::Classically, model-based segmentation procedures match magnetic resonance imaging (MRI) volumes to an expertly labeled atlas using nonlinear registration. The accuracy of these techniques are limited due to atlas biases, misregistration, and resampling error. Multi-atlas-based approaches are used as a remedy and invol...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22092

    authors: Chakravarty MM,Steadman P,van Eede MC,Calcott RD,Gu V,Shaw P,Raznahan A,Collins DL,Lerch JP

    更新日期:2013-10-01 00:00:00

  • Statistical parametric mapping of LORETA using high density EEG and individual MRI: application to mismatch negativities in schizophrenia.

    abstract::We describe a method for the statistical parametric mapping of low resolution electromagnetic tomography (LORETA) using high-density electroencephalography (EEG) and individual magnetic resonance images (MRI) to investigate the characteristics of the mismatch negativity (MMN) generators in schizophrenia. LORETA, using...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.10059

    authors: Park HJ,Kwon JS,Youn T,Pae JS,Kim JJ,Kim MS,Ha KS

    更新日期:2002-11-01 00:00:00

  • Neural mechanisms underlying the reward-related enhancement of motivation when remembering episodic memories with high difficulty.

    abstract::The motivation to receive rewards enhances episodic memories, and the motivation is modulated by task difficulty. In episodic retrieval, however, functional neuroimaging evidence regarding the motivation that mediates interactions between reward and task difficulty is scarce. The present fMRI study investigated this i...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23599

    authors: Shigemune Y,Tsukiura T,Nouchi R,Kambara T,Kawashima R

    更新日期:2017-07-01 00:00:00

  • Visual detection of motion speed in humans: spatiotemporal analysis by fMRI and MEG.

    abstract::Humans take a long time to respond to the slow visual motion of an object. It is not known what neural mechanism causes this delay. We measured magnetoencephalographic neural responses to light spot motion onset within a wide speed range (0.4-500 degrees /sec) and compared these with human reaction times (RTs). The me...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.10033

    authors: Kawakami O,Kaneoke Y,Maruyama K,Kakigi R,Okada T,Sadato N,Yonekura Y

    更新日期:2002-06-01 00:00:00

  • Functional magnetic resonance imaging (fMRI) item analysis of empathy and theory of mind.

    abstract::In contrast to conventional functional magnetic resonance imaging (fMRI) analysis across participants, item analysis allows generalizing the observed neural response patterns from a specific stimulus set to the entire population of stimuli. In the present study, we perform an item analysis on an fMRI paradigm (EmpaToM...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24966

    authors: Tholen MG,Trautwein FM,Böckler A,Singer T,Kanske P

    更新日期:2020-07-01 00:00:00

  • The imprint of childhood adversity on emotional processing in high functioning young adults.

    abstract::Adverse childhood experiences (ACEs) have been acknowledged as risk factors for increased mental health complications in adulthood, specifically increasing susceptibility to developing psychopathology upon exposure to trauma. Yet, little is known regarding the impact of mild ACEs on highly functioning population. In t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25246

    authors: Mirman A,Bick AS,Kalla C,Canetti L,Segman R,Dan R,Ben Yehuda A,Levin N,Bonne O

    更新日期:2021-02-15 00:00:00

  • The right VLPFC and downregulation of social pain: A TMS study.

    abstract::Previous studies have demonstrated that the right ventrolateral prefrontal cortex (RVLPFC) is crucially involved in downregulating physical and social pain. However, it remains unclear whether the RVLPFC is more specific to either physical or social pain. The present study compares the role of RVLPFC in emotion regula...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24881

    authors: He Z,Zhao J,Shen J,Muhlert N,Elliott R,Zhang D

    更新日期:2020-04-01 00:00:00

  • Common neural correlates of emotion perception in humans.

    abstract::Whether neuroimaging findings support discriminable neural correlates of emotion categories is a longstanding controversy. Two recent meta-analyses arrived at opposite conclusions, with one supporting (Vytal and Hamann []: J Cogn Neurosci 22:2864-2885) and the other opposing this proposition (Lindquist et al. []: Beha...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22910

    authors: Jastorff J,Huang YA,Giese MA,Vandenbulcke M

    更新日期:2015-10-01 00:00:00

  • Functional differentiation in the human ventromedial frontal lobe: A data-driven parcellation.

    abstract::Ventromedial regions of the frontal lobe (vmFL) are thought to play a key role in decision-making and emotional regulation. However, aspects of this area's functional organization, including the presence of a multiple subregions, their functional and anatomical connectivity, and the cross-species homologies of these s...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25014

    authors: Chase HW,Grace AA,Fox PT,Phillips ML,Eickhoff SB

    更新日期:2020-08-15 00:00:00

  • Somatosensory cortex: a comparison of the response to noxious thermal, mechanical, and electrical stimuli using functional magnetic resonance imaging.

    abstract::In the present study, functional magnetic resonance imaging (fMRI) was used to examine pain perception in humans. Three types of noxious stimuli were presented: electric shock (20.8 mA, 2 Hz), heat (48 degrees C), and mechanical, as well as a control tactile stimulus. The significance of activation at the level of the...

    journal_title:Human brain mapping

    pub_type: 临床试验,杂志文章

    doi:

    authors: Disbrow E,Buonocore M,Antognini J,Carstens E,Rowley HA

    更新日期:1998-01-01 00:00:00