Abstract:
:Parkinson's disease (PD) is a neurodegenerative disorder with dysfunction in cortices as well as white matter (WM) tracts. While the changes to WM structure have been extensively investigated in PD, the nature of the functional changes to WM remains unknown. In this study, the regional activity and functional connectivity of WM were compared between PD patients (n = 57) and matched healthy controls (n = 52), based on multimodel magnetic resonance imaging data sets. By tract-based spatial statistical analyses of regional activity, patients showed decreased structural-functional coupling in the left corticospinal tract compared to controls. This tract also displayed abnormally increased functional connectivity within the left post-central gyrus and left putamen in PD patients. At the network level, the WM functional network showed small-worldness in both controls and PD patients, yet it was abnormally increased in the latter group. Based on the features of the WM functional connectome, previously un-evaluated individuals could be classified with fair accuracy (73%) and area under the curve of the receiver operating characteristics (75%). These neuroimaging findings provide direct evidence for WM functional changes in PD, which is crucial to understand the functional role of fiber tracts in the pathology of neural circuits.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Ji GJ,Ren C,Li Y,Sun J,Liu T,Gao Y,Xue D,Shen L,Cheng W,Zhu C,Tian Y,Hu P,Chen X,Wang Kdoi
10.1002/hbm.24444subject
Has Abstractpub_date
2019-03-01 00:00:00pages
1253-1263issue
4eissn
1065-9471issn
1097-0193journal_volume
40pub_type
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