Abstract:
:Mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) are common among recent military veterans and involve substantial symptom overlap, making clinical distinction and effective intervention difficult. Emerging evidence of cerebral white matter abnormalities associated with mTBI may provide a biological measure to inform diagnosis and treatment, but the potentially confounding effects between PTSD and mTBI have largely gone unexamined. We collected diffusion imaging data from 133 recently-deployed American service members who developed PTSD and/or sustained mTBI, or had neither condition. Effects of PTSD and mTBI on traditional tensor-based measures of cerebral white matter integrity (fractional anisotropy [FA] and mean diffusivity [MD]) were compared in anatomical regions of interest and individual voxels throughout the brain. Generalized FA (GFA), which allows for multiple fiber orientations per voxel, was also included to improve sensitivity in white matter areas containing crossing or diverging axon bundles. PTSD was consistently associated with high GFA in select brain regions, greater likelihood of regions and voxels with abnormally low MD, and a greater number of voxels with abnormally high FA, while mTBI was associated with fewer high MD regions. Overall, PTSD was associated with more restricted diffusion (low MD) and greater anisotropy (high GFA) in regions of crossing/diverging fibers poorly characterized by a single tensor (FA), suggesting that interstitial fibers may be involved. Contrary to earlier results in a sample without PTSD, mTBI was not associated with anisotropy abnormalities, perhaps indicating the cooccurrence of PTSD and mTBI requires special consideration with regard to structural brain connectivity.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Davenport ND,Lim KO,Sponheim SRdoi
10.1002/hbm.22685subject
Has Abstractpub_date
2015-03-01 00:00:00pages
1053-64issue
3eissn
1065-9471issn
1097-0193journal_volume
36pub_type
杂志文章abstract::Imagination and creative cognition are often associated with the brain's default network (DN). Recent evidence has also linked cognitive control systems to performance on tasks involving imagination and creativity, with a growing number of studies reporting functional interactions between cognitive control and DN regi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23884
更新日期:2018-02-01 00:00:00
abstract::The hippocampus, a hub of activity for a variety of important cognitive processes, is a target of increasing interest for researchers and clinicians. Magnetoencephalography (MEG) is an attractive technique for imaging spectro-temporal aspects of function, for example, neural oscillations and network timing, especially...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24445
更新日期:2019-03-01 00:00:00
abstract::Gait disturbances, including freezing of gait, are frequent and disabling symptoms of Parkinson's disease. They often respond poorly to dopaminergic treatments. Although recent studies have shed some light on their neural correlates, their modulation by dopaminergic treatment remains quite unknown. Specifically, the i...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22679
更新日期:2015-03-01 00:00:00
abstract::Research using the Stop Signal Task employing an adaptive algorithm to accommodate individual differences often report inferior performance on the task in individuals with ADHD, OCD, and substance use disorders compared to non-clinical controls. Furthermore, individuals with deficits in inhibitory control tend to show...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24075
更新日期:2018-08-01 00:00:00
abstract::Previous studies have demonstrated that the right ventrolateral prefrontal cortex (RVLPFC) is crucially involved in downregulating physical and social pain. However, it remains unclear whether the RVLPFC is more specific to either physical or social pain. The present study compares the role of RVLPFC in emotion regula...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24881
更新日期:2020-04-01 00:00:00
abstract::Infants born prematurely are at increased risk of adverse neurodevelopmental outcome. The measurement of white matter tissue composition and structure can help predict functional performance. Specifically, measurements of myelination and indicators of myelination status in the preterm brain could be predictive of late...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23188
更新日期:2016-07-01 00:00:00
abstract::The theory of material specific lateralization of memory function posits that left and right MTL regions are asymmetrically involved in mnemonic processing of verbal and nonverbal material respectively. Lesion and functional imaging (fMRI) studies provide robust evidence for a left MTL asymmetry in the verbal memory d...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23077
更新日期:2016-03-01 00:00:00
abstract::The arcuate fasciculus (AF) connects cortical regions important in language processing, but how fiber coherence and organization relates to gray matter macrostructure remains uncharacterized. We used high-resolution structural and 30-direction diffusion imaging data from 36 healthy adults (24 male/12 female; mean age,...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21147
更新日期:2011-11-01 00:00:00
abstract::In social interactions, humans are expected to regulate interpersonal distance in response to the emotion displayed by others. Yet, the neural mechanisms implicated in approach-avoidance tendencies to distinct emotional expressions have not been fully described. Here, we investigated the neural systems implicated in r...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23467
更新日期:2017-03-01 00:00:00
abstract::Developmental neuropsychology and functional neuroimaging evidence indicates that simple and complex mental calculation is subserved by a fronto-parietal network. However, the effective connectivity (connection direction and strength) among regions within the fronto-parietal network is still unexplored. Combining even...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21119
更新日期:2011-09-01 00:00:00
abstract::Several methods are available for the identification of functional networks of brain areas using functional magnetic resonance imaging (fMRI) time-series. These typically assume a fixed relationship between the signal of the areas belonging to the same network during the entire time-series (e.g., positive correlation ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22852
更新日期:2015-09-01 00:00:00
abstract::This study investigated the cortical responses underlying magnitude comparisons of multisensory stimuli and examined the effect that musical expertise has in this process. The comparative judgments were based on a newly learned rule binding the auditory and visual stimuli within the context of magnitude comparisons: "...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22558
更新日期:2014-11-01 00:00:00
abstract::Brain circuits mediate but also constrain experience-induced plasticity and corresponding behavioral changes. Here we tested whether interindividual behavioral differences in learning a challenging new motor skill correlate with variations in brain anatomy. Young, healthy participants were scanned using structural mag...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24704
更新日期:2019-10-15 00:00:00
abstract::The ability of functional MRI to acquire data from multiple brain areas has spurred developments not only in voxel-by-voxel analyses, but also in multivariate techniques critical to quantifying the interactions between brain areas. As the number of multivariate techniques multiplies, however, few studies in any modali...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20771
更新日期:2009-11-01 00:00:00
abstract::Anxiety arising during pain expectancy can modulate the subjective experience of pain. However, individuals differ in their sensitivity to pain expectancy. The amygdale and hippocampus were proposed to mediate the behavioral response to aversive stimuli. However, their differential role in mediating anxiety-related in...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20867
更新日期:2010-02-01 00:00:00
abstract::Central brain network connections greatly contribute to overall network efficiency. Here we examined whether small vessel disease (SVD) related white matter alterations in central brain network connections have a greater impact on executive functioning than alterations in non-central brain network connections. Brain n...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23186
更新日期:2016-07-01 00:00:00
abstract::Deficits in information processing speed (IPS) are among the earliest and most prominent cognitive manifestations in mild traumatic brain injury (mTBI). We investigated the impact of white matter fiber location on IPS outcome in an individual basis assessment. A total of 112 acute mild TBI with all CT negative underwe...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25135
更新日期:2020-07-13 00:00:00
abstract::Very preterm born (VPT) children are those born before 32/40 weeks' gestational age and comprise 10% of the 15 million babies born prematurely worldwide each year. Due to advancements in neonatal medicine, the survival rate of VPT birth has increased, but few studies have investigated the nonmedical, social-cognitive ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25088
更新日期:2020-09-01 00:00:00
abstract::Advances in functional brain imaging have improved the search for potential endophenotypic markers in schizophrenia. Here, we employed independent component analysis (ICA) and dynamic causal modeling (DCM) in resting state fMRI on a sample of 35 schizophrenia patients, 20 first-degree relatives and 35 control subjects...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23477
更新日期:2017-04-01 00:00:00
abstract::Though fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders are among the most common developmental disorders, their understanding is incomplete. Diffusion tensor imaging (DTI), which is sensitive to microstructural organization in white matter, may provide a relevant measure in this population demonstrat...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20747
更新日期:2009-10-01 00:00:00
abstract::Impairment in controlled semantic association is a central feature of schizophrenia, and the goal of the current functional magnetic resonance imaging study was to identify the neural correlates of this impairment. Thirty people with schizophrenia and 30 healthy age- and gender-matched control subjects performed a tas...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22820
更新日期:2015-08-01 00:00:00
abstract::Mirror neurons, originally described in the monkey premotor area F5, are embedded in a frontoparietal network for action execution and observation. A similar Mirror Neuron System (MNS) exists in humans, including precentral gyrus, inferior parietal lobule, and superior temporal sulcus. Controversial is the inclusion o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22682
更新日期:2015-03-01 00:00:00
abstract::Functional organization units of the cerebral cortex exist over a wide range of spatial scales, from local circuits to entire cortical areas. In the last decades, scale-space representations of neuroimaging data suited to probe the multi-scale nature of cortical functional organization have been introduced and methodo...
journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
doi:10.1002/hbm.21274
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVES:To investigate the function-structure relationship of white matter within different stages of Huntington's disease (HD) using diffusion tensor imaging (DTI). EXPERIMENTAL DESIGN:From the TRACK-HD study, an early stage HD group and a premanifest gene carrier group (PMGC) were age-matched to two healthy contr...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21205
更新日期:2012-01-01 00:00:00
abstract::An increasing amount of studies apply repetetive transcranial magnetic stimulation (rTMS) to treat chronic tinnitus, yet the neurophysiological impacts have remained largely obscure. Several studies show that endogenous brain rhythms may be enhanced via diverse brain stimulation techniques applying rhythmic stimulatio...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22152
更新日期:2014-01-01 00:00:00
abstract::Demyelination and axonal damage are pathologic hallmarks of multiple sclerosis (MS), leading to loss of neuronal synchronization, functional disconnection amongst brain relays, and clinical sequelae. To investigate these properties, the primary component of the sensorimotor network was analyzed in mildly disabled Rela...
journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
doi:10.1002/hbm.20961
更新日期:2010-10-01 00:00:00
abstract::Non-quantitative MRI is prone to intersubject intensity variation rendering signal intensity level based analyses limited. Here, we propose a method that fuses non-quantitative routine T1-weighted (T1w), T2w, and T2w fluid-saturated inversion recovery sequences using independent component analysis and validate it on a...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23615
更新日期:2017-07-01 00:00:00
abstract::Individuals often have reduced ability to hear alarms in real world situations (e.g., anesthesia monitoring, flying airplanes) when attention is focused on another task, sometimes with devastating consequences. This phenomenon is called inattentional deafness and usually occurs under critical high workload conditions....
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24026
更新日期:2018-06-01 00:00:00
abstract::Positron emission tomography (PET) was used to investigate the functional anatomy of the foveal fixation system in 10 subjects scanned under three different conditions: at rest (REST), during the fixation of a central point (FIX), and while fixating the same foveal target during the presentation of peripheral visual d...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(1999)8:1<28::aid-hbm3>3.0.
更新日期:1999-01-01 00:00:00
abstract::Theoretical models of addiction suggest that a substance use disorder represents an imbalance between hypersensitive motivational processes and deficient regulatory executive functions. Working-memory (a central executive function) may be a powerful predictor of the course of drug use and drug-related problems. Goal o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22342
更新日期:2014-05-01 00:00:00