Thalamocortical sensorimotor circuit in multiple sclerosis: an integrated structural and electrophysiological assessment.

Abstract:

:Demyelination and axonal damage are pathologic hallmarks of multiple sclerosis (MS), leading to loss of neuronal synchronization, functional disconnection amongst brain relays, and clinical sequelae. To investigate these properties, the primary component of the sensorimotor network was analyzed in mildly disabled Relapsing-Remitting MS patients without sensory symptoms at the time of the investigation. By magnetoencephalography (MEG), the recruitment pattern within the primary sensory (S1) and motor (M1) areas was estimated through the morphology of the early components of somatosensory evoked magnetic fields (SEFs), after evaluating the S1 responsiveness to sensory inputs from the contralateral arm. In each hemisphere, network recruitment properties were correlated with ispilateral thalamus volume, estimated by morphometric techniques upon high-resolution 3D structural magnetic resonance images (MRI). S1 activation was preserved, whereas SEF morphology was strikingly distorted in MS patients, marking a disruption of primary somatosensory network patterning. An unbalance of S1-M1 dynamic recruitment was documented and correlated with the thalamic volume reduction in the left hemisphere. These findings support the model of MS as a disconnection syndrome, with major susceptibility to damage experienced by nodes belonging to more frequently recruited and highly specialized networks.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Dell'Acqua ML,Landi D,Zito G,Zappasodi F,Lupoi D,Rossini PM,Filippi MM,Tecchio F

doi

10.1002/hbm.20961

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

1588-600

issue

10

eissn

1065-9471

issn

1097-0193

journal_volume

31

pub_type

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