Abstract:
:Previous findings have shown that the human somatosensory cortical systems that are activated by passive nonpainful electrical stimulation include the contralateral primary somatosensory area (SI), bilateral secondary somatosensory area (SII), and bilateral insula. The present study tested the hypothesis that these areas have different sensitivities to stimulation frequency in the condition of passive stimulation. Functional MRI (fMRI) was recorded in 24 normal volunteers during nonpainful electrical median nerve stimulations at 0.5, 1, 2, and 4 Hz repetition rates in separate recording blocks in pseudorandom order. Results of the blood oxygen level-dependent (BOLD) effect showed that the contralateral SI, the bilateral SII, and the bilateral insula were active during these stimulations. As a major finding, only the contralateral SI increased its activation with the increase of the stimulus frequency at the mentioned range. The fact that nonpainful median-nerve electrical stimuli at 4 Hz induces a larger BOLD response is of interest both for basic research and clinical applications in subjects unable to perform cognitive tasks in the fMRI scanner.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Ferretti A,Babiloni C,Arienzo D,Del Gratta C,Rossini PM,Tartaro A,Romani GLdoi
10.1002/hbm.20292subject
Has Abstractpub_date
2007-07-01 00:00:00pages
645-53issue
7eissn
1065-9471issn
1097-0193journal_volume
28pub_type
杂志文章abstract::We monitored regional cerebral activity with BOLD fMRI while subjects were presented written sentences differing in their grammatical structure (subject-relative or object-relative center-embedded clauses) and their short-term memory demands (short or long antecedent-gap linkages). A core region of left posterior supe...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10006
更新日期:2002-02-01 00:00:00
abstract::The brain seeks to combine related inputs from different senses (e.g., hearing and vision), via multisensory integration. Temporal information can indicate whether stimuli in different senses are related or not. A recent human fMRI study (Noesselt et al. [2007]: J Neurosci 27:11431-11441) used auditory and visual trai...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21278
更新日期:2012-05-01 00:00:00
abstract::Correlation in functional MRI activity between spatially separated brain regions can fluctuate dynamically when an individual is at rest. These dynamics are typically characterized temporally by measuring fluctuations in functional connectivity between brain regions that remain fixed in space over time. Here, dynamics...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24202
更新日期:2018-09-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder with dysfunction in cortices as well as white matter (WM) tracts. While the changes to WM structure have been extensively investigated in PD, the nature of the functional changes to WM remains unknown. In this study, the regional activity and functional connecti...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24444
更新日期:2019-03-01 00:00:00
abstract::The sulcal morphology of the human frontal lobe is highly variable. Although the structural images usually acquired in functional magnetic resonance imaging studies provide information about this interindividual variability, this information is only rarely used to relate structure and function. Here, we investigated t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20501
更新日期:2009-01-01 00:00:00
abstract::Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be the source of these deficits. The aim of the present study was to investigate changes in whole-brain intrinsic functional connectivity according to differences in cognitive profiles in Parkinson's di...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23474
更新日期:2017-03-01 00:00:00
abstract::Patients with advanced Parkinson's disease (PD) develop disabling axial symptoms, including gait disturbances, freezing and postural instability poorly responsive to levodopa replacement therapy. The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20815
更新日期:2009-12-01 00:00:00
abstract::In the absence of vision, spatial representation may be altered. When asked to compare the relative distances between three sounds (i.e., auditory spatial bisection task), blind individuals demonstrate significant deficits and do not show an event-related potential response mimicking the visual C1 reported in sighted ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24931
更新日期:2020-06-01 00:00:00
abstract::In this communication, we extended a previously described and validated diffusion tensor imaging (DTI) method for segmenting whole brain cerebrospinal fluid (CSF) and gray and white matter (WM) tissue to provide regional volume and DTI metrics of WM tract and cortical and subcortical gray matter. This DTI-based region...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21004
更新日期:2011-01-01 00:00:00
abstract::Non-quantitative MRI is prone to intersubject intensity variation rendering signal intensity level based analyses limited. Here, we propose a method that fuses non-quantitative routine T1-weighted (T1w), T2w, and T2w fluid-saturated inversion recovery sequences using independent component analysis and validate it on a...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23615
更新日期:2017-07-01 00:00:00
abstract::The cumulative effects of repetitive subclinical head impacts during sports may result in chronic white matter (WM) changes and possibly, neurodegenerative sequelae. In this pilot study, we investigated the longitudinal WM changes over the course of two consecutive high-school football seasons and explored the long-te...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23859
更新日期:2018-01-01 00:00:00
abstract::Brain activity was studied with fMRI and steady-state visual evoked potentials (SSVEPs) in separate sessions as subjects attended to letter sequences in either the right or left visual field. The two letter sequences were superimposed on small square backgrounds that flickered at 8.6 and 12.0 Hz, respectively, and eli...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1997)5:4<287::AID-HBM14>3.
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:Early life trauma (ELT) is a significant risk factor for the onset of depression. Emerging findings indicate ELT is associated with enhanced amygdala reactivity to aversive stimuli in never-depressed healthy controls as well as those with acute depression but may be absent in non-ELT exposed depressed. The pr...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22514
更新日期:2014-09-01 00:00:00
abstract::Human neuroimaging studies have increasingly converged on the possibility that the neural representation of specific numbers may be decodable from brain activity, particularly in parietal cortex. Multivariate machine learning techniques have recently demonstrated that the neural representation of individual concrete n...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22087
更新日期:2013-10-01 00:00:00
abstract::Coordinate-based, voxel-wise meta-analysis is an exciting recent addition to the human functional brain mapping literature. In view of the critical importance of selection criteria for any valid meta-analysis, a taxonomy of experimental design should be an important tool for aiding in the design of rigorous meta-analy...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20141
更新日期:2005-05-01 00:00:00
abstract::We systematically investigated the effects of cathodal and anodal Transcranial Direct Current Stimulation (CtDCS, AtDCS) on the electric activity of primary motor cortex during a motor task. High-density electroencephalography was used to define the spatial diffusion of tDCS after effects. Ten healthy subjects perform...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22322
更新日期:2014-05-01 00:00:00
abstract::Neural dynamics can shape human experience, including pain. Pain has been linked to dynamic functional connectivity within and across brain regions of the dynamic pain connectome (consisting of the ascending nociceptive pathway (Asc), descending antinociceptive pathway (Desc), salience network (SN), and the default mo...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25245
更新日期:2021-02-15 00:00:00
abstract::Diffusion-weighted magnetic resonance imaging allows researchers and clinicians to identify individual white matter fiber tracts and map their trajectories. The reliability and interpretability of fiber-tracking procedures is improved when a priori anatomical information is used as a guide. We have developed an automa...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20619
更新日期:2009-05-01 00:00:00
abstract::Depressive symptoms often coexist with memory deficits in older adults and also are associated with incident cognitive decline in the elderly. However, little is known about the neural correlates of the association between depressive symptoms and memory deficits in nondemented elderly. Fifteen amnestic mild cognitive ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21291
更新日期:2012-06-01 00:00:00
abstract::What is the neural substrate of our capability to properly react to changes in the environment? It can be hypothesized that the anterior cingulate cortex (ACC) manages repetitive stimuli in routine conditions and alerts the dorsolateral prefrontal cortex (PFC) when stimulation unexpectedly changes. To provide evidence...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20491
更新日期:2009-01-01 00:00:00
abstract::The goal of this study was to determine the linearity of the blood oxygen level-dependent (BOLD) response, as measured by functional magnetic resonance imaging (fMRI), in category-selective regions of human visual cortex. We defined regions of the temporal lobe that were selective to faces (fusiform face area, FFA) an...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20694
更新日期:2009-08-01 00:00:00
abstract::This study examined global resting-state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus groups, with and witho...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24981
更新日期:2020-07-01 00:00:00
abstract::In depression, patients suffer from emotional and cognitive deficits, among others in semantic processing. If these semantic deficits are cognitive or interact with emotional dysfunctions, is still an open question. The aim of the current study was to investigate the influence of emotional valence on the neural correl...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22186
更新日期:2014-02-01 00:00:00
abstract::Spatial leakage effects are particularly confounding for seed-based investigations of brain networks using source-level electroencephalography (EEG) or magnetoencephalography (MEG). Various methods designed to avoid this issue have been introduced but are limited to particular assumptions about its temporal characteri...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22943
更新日期:2015-11-01 00:00:00
abstract::The development of language, social interaction, and communicative skills are remarkably different in the child with autism spectrum disorder (ASD). Atypical brain connectivity has frequently been reported in this patient population. However, the interplay between their brain connectivity and language performance rema...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22424
更新日期:2014-08-01 00:00:00
abstract::We describe a functional neuroanatomy approach that combines structural (MRI) and functional (PET) data at the individual level. For each subject MRI dataset, sulci are first localized using hemisphere surface rendering and sections and stored. Using these landmarks, the subject brain volume is then divided in 100 ana...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1997)5:4<228::AID-HBM4>3.0
更新日期:1997-01-01 00:00:00
abstract::Independent component analysis (ICA) has been shown as a promising tool for the analysis of functional magnetic resonance imaging (fMRI) time series. Each of these studies, however, used a general-purpose algorithm for performing ICA and the computational efficiency and accuracy of elicited neuronal activations have n...
journal_title:Human brain mapping
pub_type: 临床试验,杂志文章
doi:10.1002/hbm.1061
更新日期:2002-01-01 00:00:00
abstract::The overall goal of this work is to demonstrate how resting state functional magnetic resonance imaging (fMRI) signals may be used to objectively parcellate functionally heterogeneous subregions of the human amygdala into structures characterized by similar patterns of functional connectivity. We hypothesize that simi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22249
更新日期:2014-04-01 00:00:00
abstract::Recognition of objects and their relations is necessary for orienting in real life. We examined cognitive processes related to recognition of objects, their relations, and the patterns they form by using the game of chess. Chess enables us to compare experts with novices and thus gain insight in the nature of developm...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21396
更新日期:2012-11-01 00:00:00
abstract::Catechol-O-methyltransferase (COMT), located on chromosome 22q11.2, encodes an enzyme critical for dopamine flux in the prefrontal cortex. Genetic variants of COMT have been suggested to functionally manipulate prefrontal morphology and function in healthy adults. This study aims to investigate modulative roles of ind...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23161
更新日期:2016-06-01 00:00:00