Abstract:
:Neurodegenerative diseases such as Alzheimer's disease (AD) have been recognized to exhibit disease-specific brain vulnerability patterns. Apolipoprotein E (APOE) ɛ4 allele imparts a high genetic risk of developing AD. Whether the APOE ɛ4 allele damages the brain when cognitive functions are still intact is important to understand, especially for possible early detection and intervention. This study aimed to examine the selective degeneration pattern associated with the APOE ɛ4 allele in the brains of cognitively normal elderly subjects. We enrolled 35 cognitively healthy ɛ4 carriers and 40 non-carriers (53 to 81 years old) to evaluate group differences in cortical thickness and brain activation during a memory-encoding task. We also assessed the functional connectivity of the brain regions with both structural and functional damages. The results from the neuropsychological tests showed that the performances of ɛ4 carriers and non-carriers were comparable. Primarily, we found that the precuneus exhibited thinner cortical thickness and decreased deactivation during memory encoding. Furthermore, the connectivity analyses show that carriers exhibited damaged connectivity of the precuneus to several regions in the default mode network and the attention/executive control network. Our study reveals the degeneration pattern of the ɛ4 allele, which could be used as a potential biomarker for early detection for possible interventions and treatments. Hum Brain Mapp 38:271-282, 2017. © 2016 Wiley Periodicals, Inc.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Chen Y,Liu Z,Zhang J,Chen K,Yao L,Li X,Gong G,Wang J,Zhang Zdoi
10.1002/hbm.23359subject
Has Abstractpub_date
2017-01-01 00:00:00pages
271-282issue
1eissn
1065-9471issn
1097-0193journal_volume
38pub_type
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journal_title:Human brain mapping
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pub_type: 杂志文章,meta分析
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journal_title:Human brain mapping
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Human brain mapping
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doi:10.1002/hbm.23093
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