Quantitative tract-based white matter heritability in 1- and 2-year-old twins.

Abstract:

:White matter (WM) microstructure, as determined by diffusion tensor imaging (DTI), is increasingly recognized as an important determinant of cognitive function and is also altered in neuropsychiatric disorders. Little is known about genetic and environmental influences on WM microstructure, especially in early childhood, an important period for cognitive development and risk for psychiatric disorders. We studied the heritability of DTI parameters, fractional anisotropy (FA), radial diffusivity (RD) and axial diffusivity (AD) along 34 tracts, including 10 bilateral fiber pathways and the respective subdivision, using quantitative tractography in a longitudinal sample of healthy children at 1 year (N = 215) and 2 years (N = 165) of age. We found that heritabilities for whole brain AD, RD, and FA were 0.48, 0.69, and 0.72 at age 1, and 0.59, 0.77, and 0.76 at age 2 and that mean heritabilities of tract-averaged AD, RD, and FA for individual bundles were moderate (over 0.4). However, the heritability of DTI change between 1 and 2 years of age was not significant for most tracts. We also demonstrated that point-wise heritability tended to be significant in the central portions of the tracts and was generally spatially consistent at ages 1 and 2 years. These results, especially when compared to heritability patterns in neonates, indicate that the heritability of WM microstructure is dynamic in early childhood and likely reflect heterogeneous maturation of WM tracts and differential genetic and environmental influences on maturation patterns.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Lee SJ,Zhang J,Neale MC,Styner M,Zhu H,Gilmore JH

doi

10.1002/hbm.24436

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

1164-1173

issue

4

eissn

1065-9471

issn

1097-0193

journal_volume

40

pub_type

杂志文章
  • Frontal and posterior cingulate metabolic impairment in the behavioral variant of frontotemporal dementia with impaired autonoetic consciousness.

    abstract::Although memory dysfunction is not a prominent feature of the behavioral variant of frontotemporal dementia (bv-FTD), there is evidence of specific deficits of episodic memory in these patients. They also have problems monitoring their memory performance. The objective of the present study was to explore the ability t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21282

    authors: Bastin C,Feyers D,Souchay C,Guillaume B,Pepin JL,Lemaire C,Degueldre C,Collette F,Salmon E

    更新日期:2012-06-01 00:00:00

  • A novel method for integrating MEG and BOLD fMRI signals with the linear convolution model in human primary somatosensory cortex.

    abstract::Characterizing the neurovascular coupling between hemodynamic signals and their neural origins is crucial to functional neuroimaging research, even more so as new methods become available for integrating results from different functional neuroimaging modalities. We present a novel method to relate magnetoencephalograp...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20361

    authors: Nangini C,Tam F,Graham SJ

    更新日期:2008-01-01 00:00:00

  • Heritability of "small-world" networks in the brain: a graph theoretical analysis of resting-state EEG functional connectivity.

    abstract::Recent studies have shown that resting-state functional networks as studied with fMRI, EEG, and MEG may be so-called small-world networks. We investigated to what extent the characteristic features of small-world networks are genetically determined. To represent functional connectivity between brain areas, we measured...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20468

    authors: Smit DJ,Stam CJ,Posthuma D,Boomsma DI,de Geus EJ

    更新日期:2008-12-01 00:00:00

  • Do intrinsic brain functional networks predict working memory from childhood to adulthood?

    abstract::Working memory (WM) is defined as the ability to maintain a representation online to guide goal-directed behavior. Its capacity in early childhood predicts academic achievements in late childhood and its deficits are found in various neurodevelopmental disorders. We employed resting-state fMRI (rs-fMRI) of 468 partici...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25143

    authors: Zhang H,Hao S,Lee A,Eickhoff SB,Pecheva D,Cai S,Meaney M,Chong YS,Broekman BFP,Fortier MV,Qiu A

    更新日期:2020-11-01 00:00:00

  • Right-hemispheric processing of non-linguistic word features: implications for mapping language recovery after stroke.

    abstract::Verbal stimuli often induce right-hemispheric activation in patients with aphasia after left-hemispheric stroke. This right-hemispheric activation is commonly attributed to functional reorganization within the language system. Yet previous evidence suggests that functional activation in right-hemispheric homologues of...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21512

    authors: Baumgaertner A,Hartwigsen G,Roman Siebner H

    更新日期:2013-06-01 00:00:00

  • Alterations in intrinsic fronto-thalamo-parietal connectivity are associated with cognitive control deficits in psychotic disorders.

    abstract::Despite a growing number of reports about alterations in intrinsic/resting brain activity observed in patients with psychotic disorders, their relevance to well-established cognitive control deficits in this patient group is not well understood. Totally 88 clinically stabilized patients with a psychotic disorder and 5...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24362

    authors: Lencer R,Yao L,Reilly JL,Keedy SK,McDowell JE,Keshavan MS,Pearlson GD,Tamminga CA,Gershon ES,Clementz BA,Lui S,Sweeney JA

    更新日期:2019-01-01 00:00:00

  • The anatomical scaffold underlying the functional centrality of known cortical hubs.

    abstract::Cortical hubs play a fundamental role in the functional architecture of brain connectivity at rest. However, the anatomical scaffold underlying their centrality is still under debate. Certainly, the brain function and anatomy are significantly entwined through synaptogenesis and pruning mechanisms that continuously re...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23721

    authors: de Pasquale F,Della Penna S,Sabatini U,Caravasso Falletta C,Peran P

    更新日期:2017-10-01 00:00:00

  • Different structural correlates for verbal memory impairment in temporal lobe epilepsy with and without mesial temporal lobe sclerosis.

    abstract:OBJECTIVES:Memory impairment is one of the most prominent cognitive deficits in temporal lobe epilepsy (TLE). The overall goal of this study was to explore the contribution of cortical and hippocampal (subfield) damage to impairment of auditory immediate recall (AIMrecall), auditory delayed recall (ADMrecall), and audi...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21226

    authors: Mueller SG,Laxer KD,Scanlon C,Garcia P,McMullen WJ,Loring DW,Meador KJ,Weiner MW

    更新日期:2012-02-01 00:00:00

  • Diffusion tensor-based regional gray matter tissue segmentation using the international consortium for brain mapping atlases.

    abstract::In this communication, we extended a previously described and validated diffusion tensor imaging (DTI) method for segmenting whole brain cerebrospinal fluid (CSF) and gray and white matter (WM) tissue to provide regional volume and DTI metrics of WM tract and cortical and subcortical gray matter. This DTI-based region...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21004

    authors: Hasan KM,Frye RE

    更新日期:2011-01-01 00:00:00

  • Robust Bayesian estimation of the hemodynamic response function in event-related BOLD fMRI using basic physiological information.

    abstract::In BOLD fMRI data analysis, robust and accurate estimation of the Hemodynamic Response Function (HRF) is still under investigation. Parametric methods assume the shape of the HRF to be known and constant throughout the brain, whereas non-parametric methods mostly rely on artificially increasing the signal-to-noise rat...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.10100

    authors: Marrelec G,Benali H,Ciuciu P,Pélégrini-Issac M,Poline JB

    更新日期:2003-05-01 00:00:00

  • Fronto-insular-parietal network engagement underlying arithmetic word problem solving.

    abstract::Mathematical word problems are ubiquitous and standard for teaching and evaluating generalization of mathematical knowledge for real-world contexts. It is therefore concerning that the neural mechanisms of word problem solving are not well understood, as these insights represent strong potential for improving educatio...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24502

    authors: Chang TT,Lung TC,Ng CT,Metcalfe AWS

    更新日期:2019-04-15 00:00:00

  • Common and specific neural correlates underlying the spatial congruency effect induced by the egocentric and allocentric reference frame.

    abstract::The spatial location of an object can be represented in two frames of reference: egocentric (relative to the observer's body or body parts) and allocentric (relative to another object independent of the observer). The object positions relative to the two frames can be either congruent (e.g., both left or both right) o...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23508

    authors: Liu N,Li H,Su W,Chen Q

    更新日期:2017-04-01 00:00:00

  • Effects of aripiprazole and haloperidol on neural activation during a simple motor task in healthy individuals: A functional MRI study.

    abstract::The dopaminergic system plays a key role in motor function and motor abnormalities have been shown to be a specific feature of psychosis. Due to their dopaminergic action, antipsychotic drugs may be expected to modulate motor function, but the precise effects of these drugs on motor function remain unclear. We carried...

    journal_title:Human brain mapping

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/hbm.23485

    authors: Goozee R,O'Daly O,Handley R,Reis Marques T,Taylor H,McQueen G,Hubbard K,Pariante C,Mondelli V,Reinders AA,Dazzan P

    更新日期:2017-04-01 00:00:00

  • Effects of change in FreeSurfer version on classification accuracy of patients with Alzheimer's disease and mild cognitive impairment.

    abstract::Studies have found non-negligible differences in cortical thickness estimates across versions of software that are used for processing and quantifying MRI-based cortical measurements, and issues have arisen regarding these differences, as obtained estimates could potentially affect the validity of the results. However...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23139

    authors: Chepkoech JL,Walhovd KB,Grydeland H,Fjell AM,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2016-05-01 00:00:00

  • A method for multitask fMRI data fusion applied to schizophrenia.

    abstract::It is becoming common to collect data from multiple functional magnetic resonance imaging (fMRI) paradigms on a single individual. The data from these experiments are typically analyzed separately and sometimes directly subtracted from one another on a voxel-by-voxel basis. These comparative approaches, although usefu...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20204

    authors: Calhoun VD,Adali T,Kiehl KA,Astur R,Pekar JJ,Pearlson GD

    更新日期:2006-07-01 00:00:00

  • Global resting-state functional connectivity of neural oscillations in tinnitus with and without hearing loss.

    abstract::This study examined global resting-state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus groups, with and witho...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24981

    authors: Demopoulos C,Duong X,Hinkley LB,Ranasinghe KG,Mizuiri D,Garrett C,Honma S,Henderson-Sabes J,Findlay A,Racine-Belkoura C,Cheung SW,Nagarajan SS

    更新日期:2020-07-01 00:00:00

  • Neuropsychiatric symptoms in Alzheimer's disease are related to functional connectivity alterations in the salience network.

    abstract::Neuropsychiatric syndromes are highly prevalent in Alzheimer's disease (AD), but their neurobiology is not completely understood. New methods in functional magnetic resonance imaging, such as intrinsic functional connectivity or "resting-state" analysis, may help to clarify this issue. Using such approaches, alteratio...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22248

    authors: Balthazar ML,Pereira FR,Lopes TM,da Silva EL,Coan AC,Campos BM,Duncan NW,Stella F,Northoff G,Damasceno BP,Cendes F

    更新日期:2014-04-01 00:00:00

  • Segmentation of skull and scalp in 3-D human MRI using mathematical morphology.

    abstract::We present a new technique for segmentation of skull and scalp in T(1)-weighted magnetic resonance images (MRIs) of the human head. Our method uses mathematical morphological operations to generate realistic models of the skull, scalp, and brain that are suitable for electroencephalography (EEG) and magnetoencephalogr...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20159

    authors: Dogdas B,Shattuck DW,Leahy RM

    更新日期:2005-12-01 00:00:00

  • Mapping the structural and functional network architecture of the medial temporal lobe using 7T MRI.

    abstract::Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23887

    authors: Shah P,Bassett DS,Wisse LEM,Detre JA,Stein JM,Yushkevich PA,Shinohara RT,Pluta JB,Valenciano E,Daffner M,Wolk DA,Elliott MA,Litt B,Davis KA,Das SR

    更新日期:2018-02-01 00:00:00

  • The functional role of human right hippocampal/parahippocampal theta rhythm in environmental encoding during virtual spatial navigation.

    abstract::Low frequency theta band oscillations (4-8 Hz) are thought to provide a timing mechanism for hippocampal place cell firing and to mediate the formation of spatial memory. In rodents, hippocampal theta has been shown to play an important role in encoding a new environment during spatial navigation, but a similar functi...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23458

    authors: Pu Y,Cornwell BR,Cheyne D,Johnson BW

    更新日期:2017-03-01 00:00:00

  • Linear and nonlinear interrelations show fundamentally distinct network structure in preictal intracranial EEG of epilepsy patients.

    abstract::Resection of the seizure generating tissue can be highly beneficial in patients with drug-resistant epilepsy. However, only about half of all patients undergoing surgery get permanently and completely seizure free. Investigating the dependences between intracranial EEG signals adds a multivariate perspective largely u...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24816

    authors: Müller M,Caporro M,Gast H,Pollo C,Wiest R,Schindler K,Rummel C

    更新日期:2020-02-01 00:00:00

  • The influence of visual training on predicting complex action sequences.

    abstract::Linking observed and executable actions appears to be achieved by an action observation network (AON), comprising parietal, premotor, and occipitotemporal cortical regions of the human brain. AON engagement during action observation is thought to aid in effortless, efficient prediction of ongoing movements to support ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21450

    authors: Cross ES,Stadler W,Parkinson J,Schütz-Bosbach S,Prinz W

    更新日期:2013-02-01 00:00:00

  • Neural basis of the non-attentional processing of briefly presented words.

    abstract::The neural basis of the automatic activation of words was investigated in an fMRI study. In the study, words were presented briefly (51 or 151 msec) followed by a mask. To prevent attentional processing, subjects attended to the masks and not the words, and were required to make perceptual judgment about the masks. We...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.10096

    authors: Peng DL,Xu D,Jin Z,Luo Q,Ding GS,Perry C,Zhang L,Liu Y

    更新日期:2003-03-01 00:00:00

  • Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence.

    abstract:BACKGROUND:Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project. MET...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21446

    authors: Schilling C,Kühn S,Romanowski A,Banaschewski T,Barbot A,Barker GJ,Brühl R,Büchel C,Charlet K,Conrod PJ,Czech K,Dalley JW,Flor H,Häke I,Ittermann B,Ivanov N,Mann K,Lüdemann K,Martinot JL,Palafox C,Paus T,Poline J

    更新日期:2013-02-01 00:00:00

  • Modulation of neural oscillations during working memory update, maintenance, and readout: An hdEEG study.

    abstract::Working memory (WM) performance is very often measured using the n-back task, in which the participant is presented with a sequence of stimuli, and required to indicate whether the current stimulus matches the one presented n steps earlier. In this study, we used high-density electroencephalography (hdEEG) coupled to ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25283

    authors: Semprini M,Bonassi G,Barban F,Pelosin E,Iandolo R,Chiappalone M,Mantini D,Avanzino L

    更新日期:2020-11-17 00:00:00

  • Local and remote effects of transcranial direct current stimulation on the electrical activity of the motor cortical network.

    abstract::We systematically investigated the effects of cathodal and anodal Transcranial Direct Current Stimulation (CtDCS, AtDCS) on the electric activity of primary motor cortex during a motor task. High-density electroencephalography was used to define the spatial diffusion of tDCS after effects. Ten healthy subjects perform...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22322

    authors: Notturno F,Marzetti L,Pizzella V,Uncini A,Zappasodi F

    更新日期:2014-05-01 00:00:00

  • Corticospinal tract diffusion properties and robotic visually guided reaching in children with hemiparetic cerebral palsy.

    abstract::Perinatal stroke is the leading cause of hemiparetic cerebral palsy (CP), resulting in life-long disability. In this study, we examined the relationship between robotic upper extremity motor impairment and corticospinal tract (CST) diffusion properties. Thirty-three children with unilateral perinatal ischemic stroke (...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23904

    authors: Kuczynski AM,Dukelow SP,Hodge JA,Carlson HL,Lebel C,Semrau JA,Kirton A

    更新日期:2018-03-01 00:00:00

  • Reduced fronto-callosal fiber integrity in unmedicated OCD patients: a diffusion tractography study.

    abstract::It is widely accepted that abnormalities in the frontal area of the brain underpin the pathophysiology of obsessive-compulsive disorder (OCD). Fundamental to this investigation is the delineation of frontal white matter tracts including dorsal and ventral frontal projections of interhemispheric connections. While prev...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21372

    authors: Oh JS,Jang JH,Jung WH,Kang DH,Choi JS,Choi CH,Kubicki M,Shenton ME,Kwon JS

    更新日期:2012-10-01 00:00:00

  • Disrupted interactions among the hippocampal, dorsal attention, and central-executive networks in amnestic mild cognitive impairment.

    abstract::Neuroimaging investigations consistently demonstrate that the neural processes involve complex interactions between the large-scale networks. Among those networks, the dorsal attention network (DAN) and the central-executive network (CEN) have been previously shown to exhibit anti-correlated activity with the default-...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24339

    authors: Chand GB,Hajjar I,Qiu D

    更新日期:2018-12-01 00:00:00

  • Prediction of human actions: expertise and task-related effects on neural activation of the action observation network.

    abstract::The action observation network (AON) is supposed to play a crucial role when athletes anticipate the effect of others' actions in sports such as tennis. We used functional magnetic resonance imaging to explore whether motor expertise leads to a differential activation pattern within the AON during effect anticipation ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22455

    authors: Balser N,Lorey B,Pilgramm S,Stark R,Bischoff M,Zentgraf K,Williams AM,Munzert J

    更新日期:2014-08-01 00:00:00