Abstract:
:Task-based functional neuroimaging methods are increasingly being used to identify biomarkers of treatment response in psychiatric disorders. To facilitate meaningful interpretation of neural correlates of tasks and their potential changes with treatment over time, understanding the reliability of the blood-oxygen-level dependent (BOLD) signal of such tasks is essential. We assessed test-retest reliability of an emotional conflict task in healthy participants collected as part of the Canadian Biomarker Integration Network in Depression. Data for 36 participants, scanned at three time points (weeks 0, 2, and 8) were analyzed, and intra-class correlation coefficients (ICC) were used to quantify reliability. We observed moderate reliability (median ICC values between 0.5 and 0.6), within occipital, parietal, and temporal regions, specifically for conditions of lower cognitive complexity, that is, face, congruent or incongruent trials. For these conditions, activation was also observed within frontal and sub-cortical regions, however, their reliability was poor (median ICC < 0.2). Clinically relevant prognostic markers based on task-based fMRI require high predictive accuracy at an individual level. For this to be achieved, reliability of BOLD responses needs to be high. We have shown that reliability of the BOLD response to an emotional conflict task in healthy individuals is moderate. Implications of these findings to further inform studies of treatment effects and biomarker discovery are discussed.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Hassel S,Sharma GB,Alders GL,Davis AD,Arnott SR,Frey BN,Hall GB,Harris JK,Lam RW,Milev R,Müller DJ,Rotzinger S,Zamyadi M,Kennedy SH,Strother SC,MacQueen GMdoi
10.1002/hbm.24883subject
Has Abstractpub_date
2020-04-15 00:00:00pages
1400-1415issue
6eissn
1065-9471issn
1097-0193journal_volume
41pub_type
杂志文章abstract::Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that alters cortical excitability and activity in a polarity-dependent way. Stimulation for few minutes has been shown to induce plastic alterations of cortical excitability and to improve cognitive performance. These effects m...
journal_title:Human brain mapping
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journal_title:Human brain mapping
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Human brain mapping
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Human brain mapping
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journal_title:Human brain mapping
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章,评审
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pub_type: 杂志文章,随机对照试验
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