On the functional role of striatal and anterior cingulate GABA+ in stimulus-response binding.

Abstract:

:Successful response selection relies on constantly updating stimulus-response associations. The Theory of Event Coding (TEC) proposes that perception and action are conjointly coded in event files, for which fronto-striatal networks seem to play an important role. However, the exact neurobiochemical mechanism behind event file coding has remained unknown. We investigated the functional relevance of the striatal and anterior cingulate (ACC) GABAergic system using magnetic resonance spectroscopy (MRS). Specifically, the striatal and ACC concentrations of GABA+ referenced against N-acetylaspartate (NAA) were assessed in 35 young healthy males, who subsequently performed a standard event file task. As predicted by the TEC, the participants' responses were modulated by pre-established stimulus response bindings in event files. GABA+/NAA concentrations in the striatum and ACC were not correlated with the overall event binding effect. However, higher GABA+/NAA concentrations in the ACC were correlated with stronger event file binding processes in the early phase of the task. This association disappeared by the end of the task. Taken together, our findings show that striatal GABA+ levels does not seem to modulate event file binding, while ACC GABA+ seem to improve event file binding, but only as long as the participants have not yet gathered sufficient task experience. To the best of our knowledge, this is the first study providing direct evidence for the role of striatal and ACC GABA+ in stimulus-response bindings and thus insights into the brain structure-specific neurobiological aspects of the TEC.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Takacs A,Stock AK,Kuntke P,Werner A,Beste C

doi

10.1002/hbm.25335

subject

Has Abstract

pub_date

2021-01-09 00:00:00

eissn

1065-9471

issn

1097-0193

pub_type

杂志文章
  • Free-water and BOLD imaging changes in Parkinson's disease patients chronically treated with a MAO-B inhibitor.

    abstract::Rasagiline is a monoamine oxidase type B inhibitor that possesses no amphetamine-like properties, and provides symptomatic relief in early and late stages of Parkinson's disease (PD). Data in animal models of PD suggest that chronic administration of rasagiline is associated with structural changes in the substantia n...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23213

    authors: Burciu RG,Ofori E,Shukla P,Pasternak O,Chung JW,McFarland NR,Okun MS,Vaillancourt DE

    更新日期:2016-08-01 00:00:00

  • Accounting for the role of hematocrit in between-subject variations of MRI-derived baseline cerebral hemodynamic parameters and functional BOLD responses.

    abstract::Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between-subject variation of Hct thus causes variation in task-based BOLD fMRI signal changes. We first verified in healthy volunteers (n = 12) that Hct values can be derived reliably from venous blood T1 values by compariso...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23846

    authors: Xu F,Li W,Liu P,Hua J,Strouse JJ,Pekar JJ,Lu H,van Zijl PCM,Qin Q

    更新日期:2018-01-01 00:00:00

  • Automated white-matter tractography using a probabilistic diffusion tensor atlas: Application to temporal lobe epilepsy.

    abstract::Diffusion-weighted magnetic resonance imaging allows researchers and clinicians to identify individual white matter fiber tracts and map their trajectories. The reliability and interpretability of fiber-tracking procedures is improved when a priori anatomical information is used as a guide. We have developed an automa...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20619

    authors: Hagler DJ Jr,Ahmadi ME,Kuperman J,Holland D,McDonald CR,Halgren E,Dale AM

    更新日期:2009-05-01 00:00:00

  • Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence.

    abstract:BACKGROUND:Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project. MET...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21446

    authors: Schilling C,Kühn S,Romanowski A,Banaschewski T,Barbot A,Barker GJ,Brühl R,Büchel C,Charlet K,Conrod PJ,Czech K,Dalley JW,Flor H,Häke I,Ittermann B,Ivanov N,Mann K,Lüdemann K,Martinot JL,Palafox C,Paus T,Poline J

    更新日期:2013-02-01 00:00:00

  • 5-HTTLPR moderates the association between interdependence and brain responses to mortality threats.

    abstract::While behavioral research suggests an association between cultural worldview and decreased anxiety of death, the underlying neurobiological mechanisms remain unclear. Using functional MRI, we investigated whether and how the serotonin transporter promoter polymorphism (5-HTTLPR), which has been associated with mental ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23819

    authors: Luo S,Yu D,Han S

    更新日期:2017-12-01 00:00:00

  • Mapping the structural and functional network architecture of the medial temporal lobe using 7T MRI.

    abstract::Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving t...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23887

    authors: Shah P,Bassett DS,Wisse LEM,Detre JA,Stein JM,Yushkevich PA,Shinohara RT,Pluta JB,Valenciano E,Daffner M,Wolk DA,Elliott MA,Litt B,Davis KA,Das SR

    更新日期:2018-02-01 00:00:00

  • Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning.

    abstract::The goal of this study was to document current clinical practice and report patient outcomes in presurgical language functional MRI (fMRI) for epilepsy surgery. Epilepsy surgical programs worldwide were surveyed as to the utility, implementation, and efficacy of language fMRI in the clinic; 82 programs responded. Resp...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24039

    authors: Benjamin CFA,Li AX,Blumenfeld H,Constable RT,Alkawadri R,Bickel S,Helmstaedter C,Meletti S,Bronen R,Warfield SK,Peters JM,Reutens D,Połczyńska M,Spencer DD,Hirsch LJ

    更新日期:2018-07-01 00:00:00

  • Effects of individual alpha rTMS applied to the auditory cortex and its implications for the treatment of chronic tinnitus.

    abstract::An increasing amount of studies apply repetetive transcranial magnetic stimulation (rTMS) to treat chronic tinnitus, yet the neurophysiological impacts have remained largely obscure. Several studies show that endogenous brain rhythms may be enhanced via diverse brain stimulation techniques applying rhythmic stimulatio...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22152

    authors: Weisz N,Lüchinger C,Thut G,Müller N

    更新日期:2014-01-01 00:00:00

  • Revenge is sweet: Investigation of the effects of Approach-Motivated anger on the RewP in the motivated anger delay (MAD) paradigm.

    abstract::Past research has found that neural activity associated with feedback processing is enhanced by positive approach-motivated states. However, no past work has examined how reward processing changes in the context of revenge. Using a novel aggression paradigm, we sought to explore the influence of approach-motivated ang...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25177

    authors: Threadgill AH,Gable PA

    更新日期:2020-12-01 00:00:00

  • Determining the hemispheric dominance of spatial attention: a comparison between fTCD and fMRI.

    abstract::Human brain mapping allows the systematic assessment of interindividual differences in functional brain anatomy. Functional transcranial Doppler sonography (fTCD) is an imaging tool that allows for fast and mobile assessment of hemispheric lateralization of task-related brain activation. It is ideal to screen large co...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20055

    authors: Jansen A,Flöel A,Deppe M,van Randenborgh J,Dräger B,Kanowski M,Knecht S

    更新日期:2004-11-01 00:00:00

  • Drawing on mind's canvas: differences in cortical integration patterns between artists and non-artists.

    abstract::Our primary question was to learn whether mentally composing drawings of their own choice produce different brain electric features in artists and laymen. To this purpose, we studied multichannel electroencephalograph (EEG) signals from two broad groups (all participants were females): artists (professionally trained ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20104

    authors: Bhattacharya J,Petsche H

    更新日期:2005-09-01 00:00:00

  • Anticipation causes increased blood flow to the anterior cingulate cortex.

    abstract::Increased cerebral blood flow in the anterior cingulate cortex (ACC) has been noted in a range of cognitively demanding tasks studied with PET. A PET study of 10 normal males was carried out using the bolus H2(15)O intravenous injection technique to examine the effects of anticipation on blood flow to the ACC. In a se...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0193(1996)4:2<103::AID-HBM2>3.0

    authors: Murtha S,Chertkow H,Beauregard M,Dixon R,Evans A

    更新日期:1996-01-01 00:00:00

  • Effects of different viewing perspectives on somatosensory activations during observation of touch.

    abstract::Previous studies showed that neurons in the monkey premotor cortex became active when performing a particular action and also when observing the same action performed by others. These findings suggest a mirror system for action observation. Recently, bimodal neurons, sensitive both to visual and tactile stimulation, w...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20701

    authors: Schaefer M,Xu B,Flor H,Cohen LG

    更新日期:2009-09-01 00:00:00

  • Surprise beyond prediction error.

    abstract::Surprise drives learning. Various neural "prediction error" signals are believed to underpin surprise-based reinforcement learning. Here, we report a surprise signal that reflects reinforcement learning but is neither un/signed reward prediction error (RPE) nor un/signed state prediction error (SPE). To exclude these ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22513

    authors: Chumbley JR,Burke CJ,Stephan KE,Friston KJ,Tobler PN,Fehr E

    更新日期:2014-09-01 00:00:00

  • Disruption in neural phase synchrony is related to identification of inattentional deafness in real-world setting.

    abstract::Individuals often have reduced ability to hear alarms in real world situations (e.g., anesthesia monitoring, flying airplanes) when attention is focused on another task, sometimes with devastating consequences. This phenomenon is called inattentional deafness and usually occurs under critical high workload conditions....

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24026

    authors: Callan DE,Gateau T,Durantin G,Gonthier N,Dehais F

    更新日期:2018-06-01 00:00:00

  • Cortical surface-based threshold-free cluster enhancement and cortexwise mediation.

    abstract::Threshold-free cluster enhancement (TFCE) is a sensitive means to incorporate spatial neighborhood information in neuroimaging studies without using arbitrary thresholds. The majority of methods have applied TFCE to voxelwise data. The need to understand the relationship among multiple variables and imaging modalities...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23563

    authors: Lett TA,Waller L,Tost H,Veer IM,Nazeri A,Erk S,Brandl EJ,Charlet K,Beck A,Vollstädt-Klein S,Jorde A,Kiefer F,Heinz A,Meyer-Lindenberg A,Chakravarty MM,Walter H

    更新日期:2017-06-01 00:00:00

  • Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis.

    abstract::Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deforma...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22214

    authors: Younes L,Ratnanather JT,Brown T,Aylward E,Nopoulos P,Johnson H,Magnotta VA,Paulsen JS,Margolis RL,Albin RL,Miller MI,Ross CA,PREDICT-HD Investigators and Coordinators of the Huntington Study Group.

    更新日期:2014-03-01 00:00:00

  • Measurement of cortical thickness from MRI by minimum line integrals on soft-classified tissue.

    abstract::Estimating the thickness of the cerebral cortex is a key step in many brain imaging studies, revealing valuable information on development or disease progression. In this work, we present a framework for measuring the cortical thickness, based on minimizing line integrals over the probability map of the gray matter in...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20740

    authors: Aganj I,Sapiro G,Parikshak N,Madsen SK,Thompson PM

    更新日期:2009-10-01 00:00:00

  • NTU-DSI-122: A diffusion spectrum imaging template with high anatomical matching to the ICBM-152 space.

    abstract::A diffusion-weighted (DW) template in a standard coordinate system is often necessary for the analysis of white matter (WM) structures using DW images. Although several DW templates have been constructed in the ICBM-152 space, a template for diffusion spectrum imaging (DSI) is still lacking. In this study, we develope...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22860

    authors: Hsu YC,Lo YC,Chen YJ,Wedeen VJ,Isaac Tseng WY

    更新日期:2015-09-01 00:00:00

  • Linearity of the fMRI response in category-selective regions of human visual cortex.

    abstract::The goal of this study was to determine the linearity of the blood oxygen level-dependent (BOLD) response, as measured by functional magnetic resonance imaging (fMRI), in category-selective regions of human visual cortex. We defined regions of the temporal lobe that were selective to faces (fusiform face area, FFA) an...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20694

    authors: Horner AJ,Andrews TJ

    更新日期:2009-08-01 00:00:00

  • The role of the superior temporal sulcus and the mirror neuron system in imitation.

    abstract::It has been suggested that in humans the mirror neuron system provides a neural substrate for imitation behaviour, but the relative contributions of different brain regions to the imitation of manual actions is still a matter of debate. To investigate the role of the mirror neuron system in imitation we used fMRI to e...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20938

    authors: Molenberghs P,Brander C,Mattingley JB,Cunnington R

    更新日期:2010-09-01 00:00:00

  • Neural signatures of fairness-related normative decision making in the ultimatum game: a coordinate-based meta-analysis.

    abstract::The willingness to incur personal costs to enforce prosocial norms represents a hallmark of human civilization. Although recent neuroscience studies have used the ultimatum game to understand the neuropsychological mechanisms that underlie the enforcement of fairness norms; however, a precise characterization of the n...

    journal_title:Human brain mapping

    pub_type: 杂志文章,meta分析

    doi:10.1002/hbm.22649

    authors: Feng C,Luo YJ,Krueger F

    更新日期:2015-02-01 00:00:00

  • fMRI study comparing names versus pictures of objects.

    abstract::We performed an fMRI one-back recognition study aimed at distinguishing the semantic versus perceptual aspects of how objects and their written forms are processed. There were three types of visually presented items: pictures (schematic drawings of objects); words identifying these objects; and a mixed condition in wh...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.10037

    authors: Sevostianov A,Horwitz B,Nechaev V,Williams R,Fromm S,Braun AR

    更新日期:2002-07-01 00:00:00

  • Somatosensory system in two types of motor reorganization in congenital hemiparesis: topography and function.

    abstract::This study investigates the (re-)organization of somatosensory functions following early brain lesions. Using functional magnetic resonance imaging (fMRI), passive hand movement was studied. Transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG) were used as complementary methods. fMRI data was analy...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20545

    authors: Wilke M,Staudt M,Juenger H,Grodd W,Braun C,Krägeloh-Mann I

    更新日期:2009-03-01 00:00:00

  • Brain MRI shows white matter sparing in Kennedy's disease and slow-progressing lower motor neuron disease.

    abstract::The extent of central nervous system involvement in Kennedy's disease (KD) relative to other motor neuron disease (MND) phenotypes still needs to be clarified. In this study, we investigated cortical and white matter (WM) MRI alterations in 25 patients with KD, compared with 24 healthy subjects, 25 patients with spora...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24583

    authors: Spinelli EG,Agosta F,Ferraro PM,Querin G,Riva N,Bertolin C,Martinelli I,Lunetta C,Fontana A,Sorarù G,Filippi M

    更新日期:2019-07-01 00:00:00

  • The neural signature of phosphene perception.

    abstract::Artificial percepts (phosphenes) can be induced by applying transcranial magnetic stimulation (TMS) over human visual cortex. Although phosphenes have been used to study visual awareness, the neural mechanisms generating them have not yet been delineated. We directly tested the two leading hypotheses of how phosphenes...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20941

    authors: Taylor PC,Walsh V,Eimer M

    更新日期:2010-09-01 00:00:00

  • Spatial elongation of population receptive field profiles revealed by model-free fMRI back-projection.

    abstract::Estimates of visual field topographies in human visual cortex obtained through fMRI traveling wave techniques usually provide the parameters of population receptive field (pRF) location (polar angle, eccentricity) and receptive field size. These parameters are obtained by fitting the recorded data to a standard model ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24015

    authors: Merkel C,Hopf JM,Schoenfeld MA

    更新日期:2018-06-01 00:00:00

  • Structural brain correlates of cognitive and behavioral impairment in MND.

    abstract:OBJECTIVE:To assess the structural correlates of cognitive and behavioral impairment in motor neuron diseases (MND) using multimodal MRI. METHODS:One hundred one patients with sporadic MND (56 classic amyotrophic lateral sclerosis, 31 upper motor neuron phenotype, and 14 lower motor neuron phenotype) and 51 controls w...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23124

    authors: Agosta F,Ferraro PM,Riva N,Spinelli EG,Chiò A,Canu E,Valsasina P,Lunetta C,Iannaccone S,Copetti M,Prudente E,Comi G,Falini A,Filippi M

    更新日期:2016-04-01 00:00:00

  • Effective connectivity of brain regions related to visual word recognition: An fMRI study of Chinese reading.

    abstract::Past neuroimaging studies have focused on identifying specialized functional brain systems for processing different components of reading, such as orthography, phonology, and semantics. More recently, a few experiments have been performed to look into the integration and interaction of distributed neural systems for v...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22792

    authors: Xu M,Wang T,Chen S,Fox PT,Tan LH

    更新日期:2015-07-01 00:00:00

  • Reconstruction of extended cortical sources for EEG and MEG based on a Monte-Carlo-Markov-chain estimator.

    abstract::A new procedure to model extended cortical sources from EEG and MEG recordings based on a probabilistic approach is presented. The method (SPMECS) was implemented within the framework of maximum likelihood estimators. Neuronal activity generating EEG or MEG signals was characterized by the number of sources and their ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.10079

    authors: Kincses WE,Braun C,Kaiser S,Grodd W,Ackermann H,Mathiak K

    更新日期:2003-02-01 00:00:00