Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis.

Abstract:

:Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Younes L,Ratnanather JT,Brown T,Aylward E,Nopoulos P,Johnson H,Magnotta VA,Paulsen JS,Margolis RL,Albin RL,Miller MI,Ross CA,PREDICT-HD Investigators and Coordinators of the Huntington Study Group.

doi

10.1002/hbm.22214

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

792-809

issue

3

eissn

1065-9471

issn

1097-0193

journal_volume

35

pub_type

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