Abstract:
:Patients with schizophrenia have patterns of brain deficits including reduced cortical thickness, subcortical gray matter volumes, and cerebral white matter integrity. We proposed the regional vulnerability index (RVI) to translate the results of Enhancing Neuro Imaging Genetics Meta-Analysis studies to the individual level. We calculated RVIs for cortical, subcortical, and white matter measurements and a multimodality RVI. We evaluated RVI as a measure sensitive to schizophrenia-specific neuroanatomical deficits and symptoms and studied the timeline of deficit formations in: early (≤5 years since diagnosis, N = 45, age = 28.8 ± 8.5); intermediate (6-20 years, N = 30, age 43.3 ± 8.6); and chronic (21+ years, N = 44, age = 52.5 ± 5.2) patients and healthy controls (N = 76, age = 38.6 ± 12.4). All RVIs were significantly elevated in patients compared to controls, with the multimodal RVI showing the largest effect size, followed by cortical, white matter and subcortical RVIs (d = 1.57, 1.23, 1.09, and 0.61, all p < 10-6 ). Multimodal RVI was significantly correlated with multiple cognitive variables including measures of visual learning, working memory and the total score of the MATRICS consensus cognitive battery, and with negative symptoms. The multimodality and white matter RVIs were significantly elevated in the intermediate and chronic versus early diagnosis group, consistent with ongoing progression. Cortical RVI was stable in the three disease-duration groups, suggesting neurodevelopmental origins of cortical deficits. In summary, neuroanatomical deficits in schizophrenia affect the entire brain; the heterochronicity of their appearance indicates both the neurodevelopmental and progressive nature of this illness. These deficit patterns may be useful for early diagnosis and as quantitative targets for more effective treatment strategies aiming to alter these neuroanatomical deficit patterns.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Kochunov P,Fan F,Ryan MC,Hatch KS,Tan S,Jahanshad N,Thompson PM,van Erp TGM,Turner JA,Chen S,Du X,Adhikari B,Bruce H,Hare S,Goldwaser E,Kvarta M,Huang J,Tong J,Cui Y,Cao B,Tan Y,Hong LEdoi
10.1002/hbm.25045subject
Has Abstractpub_date
2020-05-28 00:00:00eissn
1065-9471issn
1097-0193pub_type
杂志文章abstract::Neural dynamics leading to conscious sensory perception have remained enigmatic in despite of large interest. Human functional magnetic resonance imaging (fMRI) studies have revealed that a co-activation of sensory and frontoparietal areas is crucial for conscious sensory perception in the several second time-scale of...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23033
更新日期:2016-01-01 00:00:00
abstract::Although reduced working memory brain activation has been reported in several brain regions of cocaine-dependent subjects compared with controls, very little is known about whether there is altered connectivity of working memory pathways in cocaine dependence. This study addresses this issue by using functional magnet...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22212
更新日期:2014-03-01 00:00:00
abstract::The hippocampus supports several important cognitive functions known to undergo substantial development during childhood and adolescence, for example, encoding and consolidation of vivid personal memories. However, diverging developmental effects on hippocampal volume have been observed across studies. It is possible ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22576
更新日期:2014-11-01 00:00:00
abstract::The neurobiological basis of reading is of considerable interest, yet analyzing data from subjects reading words aloud during functional MRI data collection can be difficult. Therefore, many investigators use surrogate tasks such as visual matching or rhyme matching to eliminate the need for spoken output. Use of thes...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22077
更新日期:2013-10-01 00:00:00
abstract::Numerous studies suggest that interhemispheric inhibition-relayed via the corpus callosum-plays an important role in unilateral hand motions. Interestingly, transcallosal inhibition appears to be indicative of a strong laterality effect, where generally the dominant hemisphere exerts inhibition on the nondominant one....
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22060
更新日期:2013-09-01 00:00:00
abstract::Non-manifesting carriers (NMC) of the G2019S mutation in the LRRK2 gene represent an "at risk" group for future development of Parkinson's disease (PD) and have demonstrated task related fMRI changes. However, resting-state networks have received less research focus, thus this study aimed to assess the integrity of th...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24543
更新日期:2019-06-01 00:00:00
abstract::The goal of this study was to determine the linearity of the blood oxygen level-dependent (BOLD) response, as measured by functional magnetic resonance imaging (fMRI), in category-selective regions of human visual cortex. We defined regions of the temporal lobe that were selective to faces (fusiform face area, FFA) an...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20694
更新日期:2009-08-01 00:00:00
abstract::The mirror neuron system (MNS) is considered crucial for human imitation and language learning and provides the basis for the development of empathy and mentalizing. Alexithymia (ALEX), which refers to deficiencies in the self-awareness of emotional states, has been reported to be associated with poor ability in vario...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20653
更新日期:2009-07-01 00:00:00
abstract::In social interactions, humans are expected to regulate interpersonal distance in response to the emotion displayed by others. Yet, the neural mechanisms implicated in approach-avoidance tendencies to distinct emotional expressions have not been fully described. Here, we investigated the neural systems implicated in r...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23467
更新日期:2017-03-01 00:00:00
abstract::Persistent developmental stuttering is a neurological disorder that commonly manifests as a motor problem. Cognitive theories, however, hold that poorly developed cognitive skills are the origins of stuttering. Working memory (WM), a multicomponent cognitive system that mediates information maintenance and manipulatio...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24366
更新日期:2019-01-01 00:00:00
abstract::Estimating the thickness of the cerebral cortex is a key step in many brain imaging studies, revealing valuable information on development or disease progression. In this work, we present a framework for measuring the cortical thickness, based on minimizing line integrals over the probability map of the gray matter in...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20740
更新日期:2009-10-01 00:00:00
abstract::How the human brain represents distinct motor features into a unique finalized action still remains undefined. Previous models proposed the distinct features of a motor act to be hierarchically organized in separated, but functionally interconnected, cortical areas. Here, we hypothesized that distinct patterns across ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22881
更新日期:2015-10-01 00:00:00
abstract::In previous work (Penny et al., [2005]: Neuroimage 24:350-362) we have developed a spatially regularised General Linear Model for the analysis of functional magnetic resonance imaging data that allows for the characterisation of regionally specific effects using Posterior Probability Maps (PPMs). In this paper we show...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20327
更新日期:2007-04-01 00:00:00
abstract::We studied the relationship between muscle activity (electromyography, EMG), force, and brain activity during isometric contractions of the index finger, on a group and individual level. Ten subjects contracted their right or left index finger at 5, 15, 30, 50, and 70% of their maximal force. Subjects received visual ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20388
更新日期:2008-03-01 00:00:00
abstract::Previous whole-brain functional connectivity studies achieved successful classifications of patients and healthy controls but only offered limited specificity as to affected brain systems. Here, we examined whether the connectivity patterns of functional systems affected in schizophrenia (SCZ), Parkinson's disease (PD...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23763
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVES:Memory impairment is one of the most prominent cognitive deficits in temporal lobe epilepsy (TLE). The overall goal of this study was to explore the contribution of cortical and hippocampal (subfield) damage to impairment of auditory immediate recall (AIMrecall), auditory delayed recall (ADMrecall), and audi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21226
更新日期:2012-02-01 00:00:00
abstract::Recent research found lasting increases in personality trait Openness in healthy individuals and patients after administration of the serotonin 2A receptor (5-HT2A R) agonist psilocybin. However, no studies have investigated whether 5-HT2A R availability as imaged using positron emission tomography (PET) is associated...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24511
更新日期:2019-05-01 00:00:00
abstract::Recent studies have shown that resting-state functional networks as studied with fMRI, EEG, and MEG may be so-called small-world networks. We investigated to what extent the characteristic features of small-world networks are genetically determined. To represent functional connectivity between brain areas, we measured...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20468
更新日期:2008-12-01 00:00:00
abstract::The applicability of functional magnetic resonance imaging (fMRI) in patients with Alzheimer's disease (AD) or schizophrenia is frequently limited by cognitive impairment, which prevents the adequate execution of complex tasks. An experimental design that puts only minor demands on the patients' cognitive ability but ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10071
更新日期:2002-12-01 00:00:00
abstract::An increasing amount of studies apply repetetive transcranial magnetic stimulation (rTMS) to treat chronic tinnitus, yet the neurophysiological impacts have remained largely obscure. Several studies show that endogenous brain rhythms may be enhanced via diverse brain stimulation techniques applying rhythmic stimulatio...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22152
更新日期:2014-01-01 00:00:00
abstract::This study investigates the (re-)organization of somatosensory functions following early brain lesions. Using functional magnetic resonance imaging (fMRI), passive hand movement was studied. Transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG) were used as complementary methods. fMRI data was analy...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20545
更新日期:2009-03-01 00:00:00
abstract::The present study examines the neural substrates for the perception of speech rhythm and intonation. Subjects listened passively to synthesized speech stimuli that contained no semantic and phonological information, in three conditions: (1) continuous speech stimuli with fixed syllable duration and fundamental frequen...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20922
更新日期:2010-07-01 00:00:00
abstract::Incongruent auditory and visual stimuli can elicit audiovisual illusions such as the McGurk effect where visual /ka/ and auditory /pa/ fuse into another percept such as/ta/. In the present study, human brain activity was measured with adaptation functional magnetic resonance imaging to investigate which brain areas su...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20884
更新日期:2010-04-01 00:00:00
abstract::Variability quenching is a widespread neural phenomenon in which trial-to-trial variability (TTV) of neural activity is reduced by repeated presentations of a sensory stimulus. However, its neural mechanism and functional significance remain poorly understood. Recurrent network dynamics are suggested as a candidate me...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24304
更新日期:2018-11-01 00:00:00
abstract::The dynamics of the human brain span multiple spatial scales, from connectivity associated with a specific region/network to the global organization, each representing different brain mechanisms. Yet brain reconfigurations at different spatial scales are seldom explored and whether they are associated with the neural ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25205
更新日期:2021-01-01 00:00:00
abstract::In this study we demonstrate that the pattern of an amygdala-centric network contributes to individual differences in trait anxiety. Individual differences in trait anxiety were predicted using maximum likelihood estimates of amygdala structural connectivity to multiple brain targets derived from diffusion-tensor imag...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22952
更新日期:2015-12-01 00:00:00
abstract::3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a psychostimulant drug producing heightened mood and facilitated social communication. In animal studies, MDMA effects are primarily mediated by serotonin (5-HT), but also by dopamine (DA) and possibly noradrenaline (NA). In humans, however, the neurochemical and ...
journal_title:Human brain mapping
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/hbm.1049
更新日期:2001-11-01 00:00:00
abstract::Joint attention behaviors include initiating one's own and responding to another's bid for joint attention to an object, person, or topic. Joint attention abilities in autism are pervasively atypical, correlate with development of language and social abilities, and discriminate children with autism from other developm...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22086
更新日期:2013-10-01 00:00:00
abstract::The presence of white matter lesions in patients with cerebral small vessel disease (SVD) is among the main causes of cognitive decline. We investigated the relation between white matter hyperintensity (WMH) locations and executive and language abilities in 442 SVD patients without dementia with varying burden of WMH....
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25273
更新日期:2020-11-24 00:00:00
abstract::Transcranial magnetic stimulation (TMS) during positron emission tomography (PET) is a novel technique for in vivo measurements of connectivity and excitability of the human cerebral cortex. Here we describe tools that allow investigators to position the stimulating coil over a target region and to verify the actual p...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00