Abnormal neural response to phonological working memory demands in persistent developmental stuttering.

Abstract:

:Persistent developmental stuttering is a neurological disorder that commonly manifests as a motor problem. Cognitive theories, however, hold that poorly developed cognitive skills are the origins of stuttering. Working memory (WM), a multicomponent cognitive system that mediates information maintenance and manipulation, is known to play an important role in speech production, leading us to postulate that the neurophysiological mechanisms underlying stuttering may be associated with a WM deficit. Using functional magnetic resonance imaging, we aimed to elucidate brain mechanisms in a phonological WM task in adults who stutter and controls. A right-lateralized compensatory mechanism for a deficit in the rehearsal process and neural disconnections associated with the central executive dysfunction were found. Furthermore, the neural abnormalities underlying the phonological WM were independent of memory load. This study demonstrates for the first time the atypical neural responses to phonological WM in PWS, shedding new light on the underlying cause of stuttering.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Yang Y,Jia F,Fox PT,Siok WT,Tan LH

doi

10.1002/hbm.24366

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

214-225

issue

1

eissn

1065-9471

issn

1097-0193

journal_volume

40

pub_type

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