Predicting functional motor potential in chronic stroke patients using diffusion tensor imaging.

Abstract:

:Electrophysiological and neuroimaging studies suggest that the integrity of ipsilesional and inter-hemispheric motor circuits is important for motor recovery after stroke. However, the extent to which each of these tracts contributes to the variance in outcome remains unclear. We examined whether diffusion tensor imaging (DTI)-derived measures of corticospinal and transcallosal tracts predict motor improvement in an experimental neurorehabilitation trial. 15 chronic stroke patients received bihemispheric transcranial direct current stimulation and simultaneous physical/occupational therapy for five consecutive days. Motor impairment was assessed prior to and after the intervention. At baseline, the patients underwent DTI; probabilistic fiber tracking was used to reconstruct the pyramidal tract (PT), alternate descending motor fibers (aMF), and transcallosal fibers connecting primary motor cortices (M1-M1). Ipsilesional corticospinal tracts (PT, aMF) and M1-M1 showed significantly decreased fractional anisotropy (FA) and increased directional diffusivities when compared to age-matched healthy controls. Partial correlations revealed that greater gains in motor function were related to higher FA values and lower directional diffusivities of transcallosal and ipsilesional corticospinal tracts. M1-M1 diffusivity had the greatest predictive value. An additional slice-by-slice analysis of FA values along the corticospinal tracts demonstrated that the more the ipsilesional FA profiles of patients resembled those of healthy controls, the greater their functional improvement. In conclusion, our study shows that DTI-derived measures can be used to predict functional potential for subsequent motor recovery in chronic stroke patients. Diffusivity parameters of individual tracts and tract combinations may help in assessing a patient's individual recovery potential and in determining optimal neurorehabilitative interventions.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Lindenberg R,Zhu LL,Rüber T,Schlaug G

doi

10.1002/hbm.21266

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

1040-51

issue

5

eissn

1065-9471

issn

1097-0193

journal_volume

33

pub_type

杂志文章
  • Altered frontal-parietal functioning during verbal working memory in children and adolescents with heavy prenatal alcohol exposure.

    abstract::This study evaluated the neural basis of verbal working memory (WM) function in a group of 20 children and adolescents with fetal alcohol spectrum disorders (FASDs) and 20 typically developing comparison participants using functional magnetic resonance imaging (fMRI). Both groups showed prominent activation in the fro...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20741

    authors: O'Hare ED,Lu LH,Houston SM,Bookheimer SY,Mattson SN,O'Connor MJ,Sowell ER

    更新日期:2009-10-01 00:00:00

  • NTU-DSI-122: A diffusion spectrum imaging template with high anatomical matching to the ICBM-152 space.

    abstract::A diffusion-weighted (DW) template in a standard coordinate system is often necessary for the analysis of white matter (WM) structures using DW images. Although several DW templates have been constructed in the ICBM-152 space, a template for diffusion spectrum imaging (DSI) is still lacking. In this study, we develope...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22860

    authors: Hsu YC,Lo YC,Chen YJ,Wedeen VJ,Isaac Tseng WY

    更新日期:2015-09-01 00:00:00

  • The human amygdala and pain: evidence from neuroimaging.

    abstract::The amygdala, a small deep brain structure involved in behavioral processing through interactions with other brain regions, has garnered increased attention in recent years in relation to pain processing. As pain is a multidimensional experience that encompasses physical sensation, affect, and cognition, the amygdala ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22199

    authors: Simons LE,Moulton EA,Linnman C,Carpino E,Becerra L,Borsook D

    更新日期:2014-02-01 00:00:00

  • Cortical brain responses during passive nonpainful median nerve stimulation at low frequencies (0.5-4 Hz): an fMRI study.

    abstract::Previous findings have shown that the human somatosensory cortical systems that are activated by passive nonpainful electrical stimulation include the contralateral primary somatosensory area (SI), bilateral secondary somatosensory area (SII), and bilateral insula. The present study tested the hypothesis that these ar...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20292

    authors: Ferretti A,Babiloni C,Arienzo D,Del Gratta C,Rossini PM,Tartaro A,Romani GL

    更新日期:2007-07-01 00:00:00

  • Population neuroscience: why and how.

    abstract::Population neuroscience endeavours to identify environmental and genetic factors that shape the function and structure of the human brain; it uses tools and knowledge of genetics, epidemiology, and cognitive neuroscience. Here, I focus on the application of population neuroscience in studies of brain development. By d...

    journal_title:Human brain mapping

    pub_type: 杂志文章,评审

    doi:10.1002/hbm.21069

    authors: Paus T

    更新日期:2010-06-01 00:00:00

  • Robust Bayesian estimation of the hemodynamic response function in event-related BOLD fMRI using basic physiological information.

    abstract::In BOLD fMRI data analysis, robust and accurate estimation of the Hemodynamic Response Function (HRF) is still under investigation. Parametric methods assume the shape of the HRF to be known and constant throughout the brain, whereas non-parametric methods mostly rely on artificially increasing the signal-to-noise rat...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.10100

    authors: Marrelec G,Benali H,Ciuciu P,Pélégrini-Issac M,Poline JB

    更新日期:2003-05-01 00:00:00

  • The brain's orienting response: An event-related functional magnetic resonance imaging investigation.

    abstract::An important function of the brain's orienting response is to enable the evaluation of novel, environmental events in order to prepare for potential behavioral action. Here, we assessed the event-related hemodynamic (erfMRI) correlates of this phenomenon using unexpected (i.e., novel) environmental sounds presented wi...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20587

    authors: Friedman D,Goldman R,Stern Y,Brown TR

    更新日期:2009-04-01 00:00:00

  • Co-speech gestures influence neural activity in brain regions associated with processing semantic information.

    abstract::Everyday communication is accompanied by visual information from several sources, including co-speech gestures, which provide semantic information listeners use to help disambiguate the speaker's message. Using fMRI, we examined how gestures influence neural activity in brain regions associated with processing semanti...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20774

    authors: Dick AS,Goldin-Meadow S,Hasson U,Skipper JI,Small SL

    更新日期:2009-11-01 00:00:00

  • Working memory training restores aberrant brain activity in adult attention-deficit hyperactivity disorder.

    abstract::The development of treatments for attention impairments is hampered by limited knowledge about the malleability of underlying neural functions. We conducted the first randomized controlled trial to determine the modulations of brain activity associated with working memory (WM) training in adults with attention-deficit...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.25164

    authors: Salmi J,Soveri A,Salmela V,Alho K,Leppämäki S,Tani P,Koski A,Jaeggi SM,Laine M

    更新日期:2020-12-01 00:00:00

  • Effects of aripiprazole and haloperidol on neural activation during a simple motor task in healthy individuals: A functional MRI study.

    abstract::The dopaminergic system plays a key role in motor function and motor abnormalities have been shown to be a specific feature of psychosis. Due to their dopaminergic action, antipsychotic drugs may be expected to modulate motor function, but the precise effects of these drugs on motor function remain unclear. We carried...

    journal_title:Human brain mapping

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/hbm.23485

    authors: Goozee R,O'Daly O,Handley R,Reis Marques T,Taylor H,McQueen G,Hubbard K,Pariante C,Mondelli V,Reinders AA,Dazzan P

    更新日期:2017-04-01 00:00:00

  • Free-water and BOLD imaging changes in Parkinson's disease patients chronically treated with a MAO-B inhibitor.

    abstract::Rasagiline is a monoamine oxidase type B inhibitor that possesses no amphetamine-like properties, and provides symptomatic relief in early and late stages of Parkinson's disease (PD). Data in animal models of PD suggest that chronic administration of rasagiline is associated with structural changes in the substantia n...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23213

    authors: Burciu RG,Ofori E,Shukla P,Pasternak O,Chung JW,McFarland NR,Okun MS,Vaillancourt DE

    更新日期:2016-08-01 00:00:00

  • Automated post-hoc noise cancellation tool for audio recordings acquired in an MRI scanner.

    abstract::There are several types of experiment in which it is useful to have subjects speak overtly in a magnetic resonance imaging (MRI) scanner, including those studying the articulatory apparatus and the neural basis of speech production, and fMRI experiments in which speech is used as a response modality. Although it is re...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20085

    authors: Cusack R,Cumming N,Bor D,Norris D,Lyzenga J

    更新日期:2005-04-01 00:00:00

  • Combining steady-state visual evoked potentials and f MRI to localize brain activity during selective attention.

    abstract::Brain activity was studied with fMRI and steady-state visual evoked potentials (SSVEPs) in separate sessions as subjects attended to letter sequences in either the right or left visual field. The two letter sequences were superimposed on small square backgrounds that flickered at 8.6 and 12.0 Hz, respectively, and eli...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0193(1997)5:4<287::AID-HBM14>3.

    authors: Hillyard SA,Hinrichs H,Tempelmann C,Morgan ST,Hansen JC,Scheich H,Heinze HJ

    更新日期:1997-01-01 00:00:00

  • BrainMap VBM: An environment for structural meta-analysis.

    abstract::The BrainMap database is a community resource that curates peer-reviewed, coordinate-based human neuroimaging literature. By pairing the results of neuroimaging studies with their relevant meta-data, BrainMap facilitates coordinate-based meta-analysis (CBMA) of the neuroimaging literature en masse or at the level of e...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24078

    authors: Vanasse TJ,Fox PM,Barron DS,Robertson M,Eickhoff SB,Lancaster JL,Fox PT

    更新日期:2018-08-01 00:00:00

  • Does the insula contribute to emotion-related distortion of time? A neuropsychological approach.

    abstract::The literature points to a large distributed brain network involved in the estimation of time. Among these regions, the role of the insular cortex is still poorly understood. At the confluence of emotional, interoceptive, and environmental signals, this brain structure has been proposed to underlie awareness of the pa...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24460

    authors: Mella N,Bourgeois A,Perren F,Viaccoz A,Kliegel M,Picard F

    更新日期:2019-04-01 00:00:00

  • The vomeronasal organ is not involved in the perception of endogenous odors.

    abstract::Chemosensory-based communication is a vital signaling tool in most species, and evidence has recently emerged in support of the notion that humans also use social chemosignals (so-called pheromones) to communicate. An ongoing controversy does exist, however, concerning the receptor organ through which these chemicals ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21035

    authors: Frasnelli J,Lundström JN,Boyle JA,Katsarkas A,Jones-Gotman M

    更新日期:2011-03-01 00:00:00

  • Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI.

    abstract::Neuroimaging studies in humans have consistently found robust activation of frontal, parietal, and temporal regions during working memory tasks. Whether these activations represent functional networks segregated by perceptual domain is still at issue. Two functional magnetic resonance imaging experiments were conducte...

    journal_title:Human brain mapping

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Belger A,Puce A,Krystal JH,Gore JC,Goldman-Rakic P,McCarthy G

    更新日期:1998-01-01 00:00:00

  • Nonlinear analysis of EEG during NREM sleep reveals changes in functional connectivity due to natural aging.

    abstract::The spatial organization of nonlinear interactions between different brain regions during the first NREM sleep stage is investigated. This is achieved via consideration of four bipolar electrode derivations, Fp1F3, Fp2F4, O1P3, O2P4, which are used to compare anterior and posterior interhemispheric interactions and le...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20052

    authors: Terry JR,Anderson C,Horne JA

    更新日期:2004-10-01 00:00:00

  • Threat as a feature in visual semantic object memory.

    abstract::Threatening stimuli have been found to modulate visual processes related to perception and attention. The present functional magnetic resonance imaging (fMRI) study investigated whether threat modulates visual object recognition of man-made and naturally occurring categories of stimuli. Compared with nonthreatening pi...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22039

    authors: Calley CS,Motes MA,Chiang HS,Buhl V,Spence JS,Abdi H,Anand R,Maguire M,Estevez L,Briggs R,Freeman T,Kraut MA,Hart J Jr

    更新日期:2013-08-01 00:00:00

  • Serotonin transporter gene methylation is associated with hippocampal gray matter volume.

    abstract:BACKGROUND:The serotonin transporter (5-HTT) and the 5-HTTLPR/rs25531 polymorphisms in its gene (SLC6A4) have been associated with depression, increased stress-response, and brain structural alterations such as reduced hippocampal volumes. Recently, epigenetic processes including SLC6A4 promoter methylation were shown ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22555

    authors: Dannlowski U,Kugel H,Redlich R,Halik A,Schneider I,Opel N,Grotegerd D,Schwarte K,Schettler C,Ambrée O,Rust S,Domschke K,Arolt V,Heindel W,Baune BT,Suslow T,Zhang W,Hohoff C

    更新日期:2014-11-01 00:00:00

  • Broadband neurophysiological abnormalities in the medial prefrontal region of the default-mode network in adults with ADHD.

    abstract::Previous investigations of the default-mode network (DMN) in persons with attention-deficit/hyperactivity disorder (ADHD) have shown reduced functional connectivity between the anterior and posterior aspects. This finding was originally demonstrated in adults with ADHD, then in youth with ADHD, and has been tentativel...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21459

    authors: Wilson TW,Franzen JD,Heinrichs-Graham E,White ML,Knott NL,Wetzel MW

    更新日期:2013-03-01 00:00:00

  • Negative BOLD responses to epileptic spikes.

    abstract::Simultaneous electroencephalogram/functional magnetic resonance imaging (EEG-fMRI) during interictal epileptiform discharges can result in positive (activation) and negative (deactivation) changes in the blood oxygenation level-dependent (BOLD) signal. Activation probably reflects increased neuronal activity and energ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20193

    authors: Kobayashi E,Bagshaw AP,Grova C,Dubeau F,Gotman J

    更新日期:2006-06-01 00:00:00

  • Mapping reliability in multicenter MRI: voxel-based morphometry and cortical thickness.

    abstract::Multicenter structural MRI studies can have greater statistical power than single-center studies. However, across-center differences in contrast sensitivity, spatial uniformity, etc., may lead to tissue classification or image registration differences that could reduce or wholly offset the enhanced statistical power o...

    journal_title:Human brain mapping

    pub_type: 杂志文章,多中心研究

    doi:10.1002/hbm.20991

    authors: Schnack HG,van Haren NE,Brouwer RM,van Baal GC,Picchioni M,Weisbrod M,Sauer H,Cannon TD,Huttunen M,Lepage C,Collins DL,Evans A,Murray RM,Kahn RS,Hulshoff Pol HE

    更新日期:2010-12-01 00:00:00

  • Topographical relationships between arcuate fasciculus connectivity and cortical thickness.

    abstract::The arcuate fasciculus (AF) connects cortical regions important in language processing, but how fiber coherence and organization relates to gray matter macrostructure remains uncharacterized. We used high-resolution structural and 30-direction diffusion imaging data from 36 healthy adults (24 male/12 female; mean age,...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.21147

    authors: Phillips OR,Clark KA,Woods RP,Subotnik KL,Asarnow RF,Nuechterlein KH,Toga AW,Narr KL

    更新日期:2011-11-01 00:00:00

  • Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task.

    abstract::Functional imaging studies consistently find that emotional stimuli activate the posterior cingulate cortex, a region that appears to have memory-related functions. However, prior imaging studies have not controlled for non-emotional stimulus features that might activate this region by engaging memory processes unrela...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.10075

    authors: Maddock RJ,Garrett AS,Buonocore MH

    更新日期:2003-01-01 00:00:00

  • Dynamic functional connectivity shapes individual differences in associative learning.

    abstract::Current neuroscientific research has shown that the brain reconfigures its functional interactions at multiple timescales. Here, we sought to link transient changes in functional brain networks to individual differences in behavioral and cognitive performance by using an active learning paradigm. Participants learned ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23285

    authors: Fatima Z,Kovacevic N,Misic B,McIntosh AR

    更新日期:2016-11-01 00:00:00

  • The anatomical scaffold underlying the functional centrality of known cortical hubs.

    abstract::Cortical hubs play a fundamental role in the functional architecture of brain connectivity at rest. However, the anatomical scaffold underlying their centrality is still under debate. Certainly, the brain function and anatomy are significantly entwined through synaptogenesis and pruning mechanisms that continuously re...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23721

    authors: de Pasquale F,Della Penna S,Sabatini U,Caravasso Falletta C,Peran P

    更新日期:2017-10-01 00:00:00

  • Cortical source of blink-related delta oscillations and their correlation with levels of consciousness.

    abstract::Recently, blink-related delta oscillations (delta BROs) have been observed in healthy subjects during spontaneous blinking at rest. Delta BROs have been linked with continuous gathering of information from the surrounding environment, which is classically attributed to the precuneus. Furthermore, fMRI studies have sho...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22056

    authors: Bonfiglio L,Olcese U,Rossi B,Frisoli A,Arrighi P,Greco G,Carozzo S,Andre P,Bergamasco M,Carboncini MC

    更新日期:2013-09-01 00:00:00

  • The influence of ageing on complex brain networks: a graph theoretical analysis.

    abstract:OBJECTIVE:To determine the functional connectivity of different EEG bands at the "baseline" situation (rest) and during mathematical thinking in children and young adults to study the maturation effect on brain networks at rest and during a cognitive task. METHODS:Twenty children (8-12 years) and twenty students (21-2...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.20492

    authors: Micheloyannis S,Vourkas M,Tsirka V,Karakonstantaki E,Kanatsouli K,Stam CJ

    更新日期:2009-01-01 00:00:00

  • Functional centrality of amygdala, striatum and hypothalamus in a "small-world" network underlying joy: an fMRI study with music.

    abstract::Current knowledge about small-world networks underlying emotions is sparse, and confined to functional magnetic resonance imaging (fMRI) studies using resting-state paradigms. This fMRI study applied Eigenvector Centrality Mapping (ECM) and functional connectivity analysis to reveal neural small-world networks underly...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.22416

    authors: Koelsch S,Skouras S

    更新日期:2014-07-01 00:00:00