Abstract:
:Electrophysiological and neuroimaging studies suggest that the integrity of ipsilesional and inter-hemispheric motor circuits is important for motor recovery after stroke. However, the extent to which each of these tracts contributes to the variance in outcome remains unclear. We examined whether diffusion tensor imaging (DTI)-derived measures of corticospinal and transcallosal tracts predict motor improvement in an experimental neurorehabilitation trial. 15 chronic stroke patients received bihemispheric transcranial direct current stimulation and simultaneous physical/occupational therapy for five consecutive days. Motor impairment was assessed prior to and after the intervention. At baseline, the patients underwent DTI; probabilistic fiber tracking was used to reconstruct the pyramidal tract (PT), alternate descending motor fibers (aMF), and transcallosal fibers connecting primary motor cortices (M1-M1). Ipsilesional corticospinal tracts (PT, aMF) and M1-M1 showed significantly decreased fractional anisotropy (FA) and increased directional diffusivities when compared to age-matched healthy controls. Partial correlations revealed that greater gains in motor function were related to higher FA values and lower directional diffusivities of transcallosal and ipsilesional corticospinal tracts. M1-M1 diffusivity had the greatest predictive value. An additional slice-by-slice analysis of FA values along the corticospinal tracts demonstrated that the more the ipsilesional FA profiles of patients resembled those of healthy controls, the greater their functional improvement. In conclusion, our study shows that DTI-derived measures can be used to predict functional potential for subsequent motor recovery in chronic stroke patients. Diffusivity parameters of individual tracts and tract combinations may help in assessing a patient's individual recovery potential and in determining optimal neurorehabilitative interventions.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Lindenberg R,Zhu LL,Rüber T,Schlaug Gdoi
10.1002/hbm.21266subject
Has Abstractpub_date
2012-05-01 00:00:00pages
1040-51issue
5eissn
1065-9471issn
1097-0193journal_volume
33pub_type
杂志文章abstract::This study evaluated the neural basis of verbal working memory (WM) function in a group of 20 children and adolescents with fetal alcohol spectrum disorders (FASDs) and 20 typically developing comparison participants using functional magnetic resonance imaging (fMRI). Both groups showed prominent activation in the fro...
journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
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journal_title:Human brain mapping
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journal_title:Human brain mapping
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journal_title:Human brain mapping
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:Human brain mapping
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20085
更新日期:2005-04-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24078
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24460
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21035
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journal_title:Human brain mapping
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1998-01-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20052
更新日期:2004-10-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22039
更新日期:2013-08-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22555
更新日期:2014-11-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21459
更新日期:2013-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20193
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pub_type: 杂志文章,多中心研究
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journal_title:Human brain mapping
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10075
更新日期:2003-01-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23285
更新日期:2016-11-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23721
更新日期:2017-10-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22056
更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
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