Altered frontal-parietal functioning during verbal working memory in children and adolescents with heavy prenatal alcohol exposure.

Abstract:

:This study evaluated the neural basis of verbal working memory (WM) function in a group of 20 children and adolescents with fetal alcohol spectrum disorders (FASDs) and 20 typically developing comparison participants using functional magnetic resonance imaging (fMRI). Both groups showed prominent activation in the frontal-parietal-cerebellar network known to be important for verbal WM. Despite equivalent behavioral performance between groups, alcohol-exposed individuals showed increased activation relative to typically developing individuals in left dorsal frontal and left inferior parietal cortices, and bilateral posterior temporal regions during verbal WM. These effects remained even when group differences on IQ were statistically controlled. This pattern of increased activation coupled with equivalent behavioral performance between groups suggests that individuals with FASD recruit a more extensive network of brain regions during verbal WM relative to typically developing individuals. These findings may suggest that frontal-parietal processing during verbal WM is less efficient in alcohol-exposed individuals.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

O'Hare ED,Lu LH,Houston SM,Bookheimer SY,Mattson SN,O'Connor MJ,Sowell ER

doi

10.1002/hbm.20741

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

3200-8

issue

10

eissn

1065-9471

issn

1097-0193

journal_volume

30

pub_type

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